Cytokeratin 19 (KRT19) Biotinylated Mouse Monoclonal Detection Antibody [Clone ID: OTI5H6]
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Specifications
Product Data | |
Clone Name | OTI5H6 |
Applications | ELISA |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment of human KRT19 (NP_002267) produced in E.coli. |
Formulation | PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 0.5mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Predicted Protein Size | 43.9 kDa |
Gene Name | keratin 19 |
Database Link | |
Background | Keratin-19 (KRT19) also known as keratin, type I cytoskeletal 19, cytokeratin-19 (CK-19), or CYFRA 21-1, is a 40 kDa protein that in humans is encoded by the KRT19 gene. Keratin 19 is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 19 is a type I keratin. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. KRT19 is the most used marker for the RT-PCR-mediated detection of tumor cells disseminated in lymph nodes, peripheral blood, and bone marrow of breast cancer patients. There is a positive correlation between higher expression of KRT19 in some kind of cancers and worse patient survival, where it serves as a diagnostic or prognostic biomarker. |
Synonyms | CK19; K1CS; K19 |
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