GBA Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI1D12]
Other products for "GBA"
Specifications
Product Data | |
Clone Name | OTI1D12 |
Applications | IHC, WB |
Recommended Dilution | WB 1:2000, IHC 1:150 |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 40-315 of human GBA (NP_000148) produced in E.coli. |
Formulation | PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 0.5 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | HRP |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 55.5 kDa |
Gene Name | glucosylceramidase beta |
Database Link | |
Background | This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010] |
Synonyms | GBA1; GCB; GLUC |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Lysosome, Metabolic pathways, Other glycan degradation, Sphingolipid metabolism |
Documents
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