CD30 (TNFRSF8) Mouse Monoclonal Antibody [Clone ID: OTI2G7]

CAT#: TA804021

TNFRSF8 mouse monoclonal antibody, clone OTI2G7 (formerly 2G7)

Product Images

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-TNFRSF8 mouse monoclonal antibody. (TA804021)

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  Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-TNFRSF8 mouse monoclonal antibody. (TA804021)

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  Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-TNFRSF8 mouse monoclonal antibody. (TA804021)

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  Flow cytometric Analysis of K562 and Ramos cells, using anti-TNFRSF8 antibody (TA804021), (Red), compared to a nonspecific negative control antibody (TA50011), (Blue) (1:100).

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  Flow cytometric Analysis of k562 cells, using anti-TNFRSF8 antibody (TA804021), (Red), compared to a nonspecific negative control antibody (TA50011), (Blue).

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Specifications

Product Data

• Clone Name: OTI2G7
• Applications: FC, IHC
• Recommended Dilution: IHC 1:150, FLOW 1:100
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human recombinant protein fragment corresponding to amino acids 19-379 of human TNFRSF8 (NP_001234) produced in E.coli.
• Formulation: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: tumor necrosis factor receptor superfamily member 8
• Database Link:
  NP_001234
  Entrez Gene 943 Human
  UniProt ID P28908
• Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
• Synonyms: CD30; D1S166E; Ki-1

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Stem cell - Pluripotency, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction