JIP1 (MAPK8IP1) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI3A12]

CAT#: TA809896BM

MAPK8IP1 mouse monoclonal antibody,clone OTI3A12, HRP conjugated


USD 420.00

4 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Clone Name OTI3A12
Applications WB
Recommended Dilution WB 1:2000
Reactivities Human, Mouse, Rat
Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Full length human recombinant protein of human MAPK8IP1 (NP_005447) produced in HEK293T cell.
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 0.5 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation HRP
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 77.3 kDa
Gene Name mitogen-activated protein kinase 8 interacting protein 1
Background This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]
Synonyms IB1; JIP-1; JIP1; PRKM8IP
Reference Data
Protein Families Druggable Genome
Protein Pathways MAPK signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.