M6PR Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI2F3]

CAT#: TA812721AM

M6PR mouse monoclonal antibody,clone OTI2F3, Biotinylated

Product Images

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY M6PR (RC201277, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-M6PR (1:500). Positive lysates LY419372 (100ug) and LC419372 (20ug) can be purchased separately from OriGene.

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  Western blot analysis of extracts (35ug) from 13 different cell lines by using anti-M6PR monoclonal antibody (1:500).

Specifications

Product Data

• Clone Name: OTI2F3
• Applications: WB
• Recommended Dilution: WB 1:500
• Reactivities: Human, Monkey, Mouse, Rat, Dog
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human recombinant protein fragment corresponding to amino acids 27-185 of human M6PR (NP_002346) produced in E.coli.
• Formulation: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 0.5 mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Biotin
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 30.99 kDa
• Gene Name: mannose-6-phosphate receptor, cation dependent
• Database Link:
  NP_002346
  Entrez Gene 17113 MouseEntrez Gene 312689 RatEntrez Gene 477700 DogEntrez Gene 716696 MonkeyEntrez Gene 4074 Human
  UniProt ID P20645
• Background: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. [UniProtKB/Swiss-Prot Function]
• Synonyms: CD-M6PR; CD-MPR; MPR-46; MPR 46; MPR46; SMPR

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Lysosome