ATR Rabbit Polyclonal Antibody

CAT#: TA890100S

Rabbit Polyclonal anti-ATR Antibody

Size: 30 ul 100 ul


 

USD 159.00

2 Days*

Size
    • 30 ul

Product Images

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Specifications

Product Data
Applications WB
Recommended Dilution WB: 1:500~2000
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant protein of human ATR
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration 1.36 mg/ml
Purification Purified from the immunized serum by affinity chromatography (Protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 301.2 kDa
Gene Name ATR serine/threonine kinase
Background The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008]
Synonyms FCTCS; FRP1; MEC1; SCKL; SCKL1
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Cell cycle, p53 signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.