PAX5 Rabbit Polyclonal Antibody

CAT#: TA899004S

PAX5 Rabbit Polyclonal Antibody


USD 159.00

2 Weeks*

Size
    • 30 ul

Product Images

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Specifications

Product Data
Applications ELISA, WB
Recommended Dilution ELISA 1:5000-10000, WB 1:500
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen This antibody is raised against a recombinant protein of PAX5 expressed in HEK293 cells
Formulation Tissue culture buffer containing 1% BSA and 0.02% Sodium azide
Concentration Lot dependent; please refer to CoA along with shipment
Purification Purified from the immunized serum by affinity chromatography (Protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 42 kDa
Gene Name paired box 5
Background This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Synonyms ALL3; BSAP
Reference Data
Protein Families Transcription Factors

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.