Desmin (DES) Mouse Monoclonal Antibody [Clone ID: UMAB166]

CAT#: UM570107

Desmin mouse monoclonal antibody,clone UMAB166

Product Images

Western blot of human tissue lysates (15ug) from colon. Diluation: 1:500.

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  Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-DES mouse monoclonal antibody. (UM500107, heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120°C for 3min)

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  Immunohistochemical staining of paraffin-embedded Human adult heart tissue using anti-DES mouse monoclonal antibody. (UM500107, heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120°C for 3min)

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  Immunofluorescent staining of HeLa cells using anti-DES mouse monoclonal antibody (UM500107, green, 1:50). Actin filaments were labeled with Alexa Fluor® 594 Phalloidin (red), and nuclear with DAPI (blue). Scale bar, 20µm.

Specifications

Product Data

• Clone Name: UMAB166
• Applications: IF, IHC, WB
• Recommended Dilution: IHC 1:200
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Full length human recombiant protein of human DES(NP_001918) produced in E.coli.
• Formulation: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 53.4 kDa
• Gene Name: Homo sapiens desmin (DES), mRNA.
• Database Link:
  NP_001918
  Entrez Gene 13346 MouseEntrez Gene 64362 RatEntrez Gene 1674 Human
  UniProt ID P17661
• Background: This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008]
• Synonyms: CSM1; CSM2; LGMD2R

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)