DOCK2 Mouse Monoclonal Antibody [Clone ID: UMAB142]

CAT#: UM870039

DOCK2 mouse monoclonal antibody,clone UMAB142

Size: 30 ul 100 ul


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USD 180.00

In Stock*

Size
    • 30 ul

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Specifications

Product Data
Clone Name UMAB142
Applications IF, IHC, WB
Recommended Dilution WB 1:2000, IHC 1:150
Reactivities Human, Mouse, Rat
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 1544-1830 of human DOCK2 (NP_004937) produced in E.coli.
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 0.5~1.0 mg/ml (Lot Dependent)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name Homo sapiens dedicator of cytokinesis 2 (DOCK2), transcript variant 1, mRNA.
Background The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011]
Synonyms FLJ46592; KIAA0209
Reference Data
Protein Families Druggable Genome
Protein Pathways Chemokine signaling pathway, Fc gamma R-mediated phagocytosis

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