CD45 (PTPRC) Mouse Monoclonal Antibody [Clone ID: UMAB291]

CAT#: UM870180

CD45(PTPRC) mouse monoclonal antibody, clone UMAB291

USD 180.00

In Stock*

Size
    • 30 ul

Frequently bought together (2)
PTPRC HEK293T cell transient overexpression lysate (as WB positive control)
    • 20 ug

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Transient overexpression lysate of protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 1
    • 100 ug

USD 605.00

Other products for "PTPRC"

Specifications

Product Data
Clone Name UMAB291
Applications IHC
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 221-396 of human CD45 (NP_002829) produced in E.coli.
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Predicted Protein Size 147.1 kDa
Gene Name Homo sapiens protein tyrosine phosphatase receptor type C (PTPRC), transcript variant 1, mRNA.
Background The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
Synonyms B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Phosphatase, Transmembrane
Protein Pathways Cell adhesion molecules (CAMs), Fc gamma R-mediated phagocytosis, Primary immunodeficiency, T cell receptor signaling pathway

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