Desmin (DES) Mouse Monoclonal Antibody [Clone ID: UMAB302]

CAT#: UM870184

Desmin(DES) mouse monoclonal antibody,clone UMAB302

Product Images

IHC staining of FFPE human gastric cancer using anti-Desmin(DES) mouse monoclonal antibody (UM800184) and Polink-2 HRP polymer detection kit (D22-110). Heat-induced epitope retrieval by EDTA solution buffer pH 8.0 (B04C-100) at 120°C for 3 min. The brown stain indicates positive stain, blue is the counter stain.

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  IHC staining of FFPE human appendix tissue with in the normal limits using anti-Desmin(DES) mouse monoclonal antibody (UM800184) and Polink-2 HRP polymer detection kit (D22-110). Heat-induced epitope retrieval by EDTA solution buffer pH 8.0 (B04C-100) at 120°C for 3 min. The brown stain indicates positive stain, blue is the counter stain.

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  IHC staining of FFPE human leiomyoma tissue using anti-Desmin(DES) mouse monoclonal antibody (UM800184) and Polink-2 HRP polymer detection kit (D22-110). Heat-induced epitope retrieval by EDTA solution buffer pH 8.0 (B04C-100) at 120°C for 3 min. The brown stain indicates positive stain, blue is the counter stain.

Specifications

Product Data

• Clone Name: UMAB302
• Applications: IHC
• Recommended Dilution: IHC 1:16000
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human Desmin(DES) (NP_001918). The exact sequence is proprietary.
• Formulation: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 1.00mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Predicted Protein Size: 53.5 kDa
• Gene Name: desmin
• Database Link:
  NP_001918
  Entrez Gene 1674 Human
  UniProt ID P17661
• Background: This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008]
• Synonyms: CDCD3; CSM1; CSM2; LGMD1D; LGMD1E; LGMD2R

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)