bcl 6 (BCL6) Rabbit Monoclonal Antibody [Clone ID: UMAB299]

CAT#: UM900004

BCL6 Rabbit monoclonal antibody,clone UMAB299

Product Images

IHC staining of FFPE human lymphoma tissue using anti-BCL6 rabbit monoclonal antibody (UM900004) and Polink-2 HRP polymer detection kit (D22-110). Heat-induced epitope retrieval by EDTA solution buffer pH 9.0 (B06C-50) at 120°C for 3 min. The brown stain indicates positive stain, blue is the counter stain.

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  IHC staining of FFPE human tonsil tissue with in the normal limits using anti-BCL6 rabbit monoclonal antibody (UM900004) and Polink-2 HRP polymer detection kit (D22-110). Heat-induced epitope retrieval by EDTA solution buffer pH 9.0 (B06C-50) at 120°C for 3 min. The brown stain indicates positive stain, blue is the counter stain.

Specifications

Product Data

• Clone Name: UMAB299
• Applications: IHC
• Recommended Dilution: IHC 1:1200
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human BCL6 (NP_001697). The exact sequence is proprietary.
• Formulation: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 1.00mg/ml
• Purification: Purified from cell culture supernatant by affinity chromatography(protein A/G)
• Conjugation: Unconjugated
• Predicted Protein Size: 78.7 kDa
• Gene Name: Homo sapiens BCL6 transcription repressor (BCL6), transcript variant 1, mRNA.
• Database Link:
  NP_001697
  Entrez Gene 604 Human
  UniProt ID P41182
• Background: The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
• Synonyms: BCL5; BCL6A; LAZ3; ZBTB27; ZNF51

Reference Data

• Protein Families: Druggable Genome, Transcription Factors