Human Perforin ELISpot Pair, 10 x 96-well

CAT#: EA101822

Human Perforin ELISpot Pair, 10 x 96-well

Specifications

Product Data

• Format: 10 x 96-well
• Assay Type: Enzyme-Linked ImmunoSpot (ELISpot)
• Signal: Colorimetric
• Specificity: Recognizes natural human Perforin
• Cross Reactivity: No cross reactivity with other human soluble molecules
• Components: ELISpot matched antibody pairs are extensively validated and include pre-titrated capture antibody and biotinylated detection antibody. Antibodies are supplied in quantities sufficient for 10 x 96 samples.
• Background: The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
• Gene Symbol: PRF1