TRAIL (TNFSF10) (NM_003810) Human 3' UTR Clone

CAT#: SC210305

3`UTR clone of tumor necrosis factor (ligand) superfamily member 10 (TNFSF10) for miRNA target validation

Specifications

Product Data

• Vector: pMirTarget
• Species: Human
• Transfection Reporter: RFP
• Assay Reporter: Luciferase
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Symbol: TNFSF10
• Synonyms: Apo-2L; APO2L; CD253; TL2; TNLG6A; TRAIL
• ACCN: NM_003810
• Insert Size: 863
• Sequence Data:
  Insert Sequence

  >SC210305 3'UTR clone of NM_003810
  The sequence shown below is from the reference sequence of NM_003810. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon
  
  
  CAATTGGCAGAGCTCAGAATTCAAGCGATCGC
  
  ACATGGACCATGAAGCCAGTTTTTTCGGGGCCTTTTTAGTTGGCTAACTGACCTGGAAAGAAAAAGCAAT
  AACCTCAAAGTGACTATTCAGTTTTCAGGATGATACACTATGAAGATGTTTCAAAAAATCTGACCAAAAC
  AAACAAACAGAAAACAGAAAACAAAAAAACCTCTATGCAATCTGAGTAGAGCAGCCACAACCAAAAAATT
  CTACAACACACACTGTTCTGAAAGTGACTCACTTATCCCAAGAGAATGAAATTGCTGAAAGATCTTTCAG
  GACTCTACCTCATATCAGTTTGCTAGCAGAAATCTAGAAGACTGTCAGCTTCCAAACATTAATGCAATGG
  TTAACATCTTCTGTCTTTATAATCTACTCCTTGTAAAGACTGTAGAAGAAAGAGCAACAATCCATCTCTC
  AAGTAGTGTATCACAGTAGTAGCCTCCAGGTTTCCTTAAGGGACAACATCCTTAAGTCAAAAGAGAGAAG
  AGGCACCACTAAAAGATCGCAGTTTGCCTGGTGCAGTGGCTCACACCTGTAATCCCAACATTTTGGGAAC
  CCAAGGTGGGTAGATCACGAGATCAAGAGATCAAGACCATAGTGACCAACATAGTGAAACCCCATCTCTA
  CTGAAAGTACAAAAATTAGCTGGGTGTGTTGGCACATGCCTGTAGTCCCAGCTACTTGAGAGGCTGAGGC
  AAGAGAATTGTTTGAACCCGGGAGGCAGAGGTTGCAGTGTGGTGAGATCATGCCACTACACTCCAGCCTG
  GCGACAGAGCGAGACTTGGTTTCAAAAAAAAAAAAAAAAAAAACTTCAGTAAGTACGTGTTATTTTTTTC
  AATAAAATTCTATTACAGTATGT
  
  ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
• Restriction Sites: SgfI-MluI
• OTI Disclaimer: Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).

Reference Data

• RefSeq: NM_003810.2
• Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
• Locus ID: 8743