IL4R (NM_000418) Human 3' UTR Clone

CAT#: SC211365

3`UTR clone of interleukin 4 receptor (IL4R) transcript variant 1 for miRNA target validation

Specifications

Product Data

• Vector: pMirTarget
• Species: Human
• Transfection Reporter: RFP
• Assay Reporter: Luciferase
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Symbol: IL4R
• Synonyms: CD124; IL-4RA; IL4RA
• ACCN: NM_000418
• Insert Size: 964 bp
• Sequence Data:
  Insert Sequence

  >SC211365 3'UTR clone of NM_000418
  The sequence shown below is from the reference sequence of NM_000418. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon
  
  
  CAATTGGCAGAGCTCAGAATTCAAGCGATCGC
  
  GTGAACTTTGTCTCCGTGGGACCCACATACATGAGGGTCTCTTAGGTGCATGTCCTCTTGTTGCTGAGTC
  TGCAGATGAGGACTAGGGCTTATCCATGCCTGGGAAATGCCACCTCCTGGAAGGCAGCCAGGCTGGCAGA
  TTTCCAAAAGACTTGAAGAACCATGGTATGAAGGTGATTGGCCCCACTGACGTTGGCCTAACACTGGGCT
  GCAGAGACTGGACCCCGCCCAGCATTGGGCTGGGCTCGCCACATCCCATGAGAGTAGAGGGCACTGGGTC
  GCCGTGCCCCACGGCAGGCCCCTGCAGGAAAACTGAGGCCCTTGGGCACCTCGACTTGTGAACGAGTTGT
  TGGCTGCTCCCTCCACAGCTTCTGCAGCAGACTGTCCCTGTTGTAACTGCCCAAGGCATGTTTTGCCCAC
  CAGATCATGGCCCACGTGGAGGCCCACCTGCCTCTGTCTCACTGAACTAGAAGCCGAGCCTAGAAACTAA
  CACAGCCATCAAGGGAATGACTTGGGCGGCCTTGGGAAATCGATGAGAAATTGAACTTCAGGGAGGGTGG
  TCATTGCCTAGAGGTGCTCATTCATTTAACAGAGCTTCCTTAGGTTGATGCTGGAGGCAGAATCCCGGCT
  GTCAAGGGGTGTTCAGTTAAGGGGAGCAACAGAGGACATGAAAAATTGCTATGACTAAAGCAGGGACAAT
  TTGCTGCCAAACACCCATGCCCAGCTGTATGGCTGGGGGCTCCTCGTATGCATGGAACCCCCAGAATAAA
  TATGCTCAGCCACCCTGTGGGCCGGGCAATCCAGACAGCAGGCATAAGGCACCAGTTACCCTGCATGTTG
  GCCCAGACCTCAGGTGCTAGGGAAGGCGGGAACCTTGGGTTGAGTAATGCTCGTCTGTGTGTTTTAGTTT
  CATCACCTGTTATCTGTGTTTGCTGAGGAGAGTGGAACAGAAGGGGTGGAGTTT
  
  ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
• Restriction Sites: SgfI-MluI
• OTI Disclaimer: Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as 10 ug dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials.

Reference Data

• RefSeq: NM_000418.2
• Summary: 'This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]'
• Locus ID: 3566