Caspase 8 (CASP8) (NM_033355) Human 3' UTR Clone

CAT#: SC212572

3`UTR clone of caspase 8 apoptosis-related cysteine peptidase (CASP8) transcript variant B for miRNA target validation

Reconstitution Protocol

USD 560.00

4 Weeks*

Size
    • 10 ug

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Specifications

Product Data
Vector pMirTarget
Species Human
Transfection Reporter RFP
Assay Reporter Luciferase
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Symbol CASP8
Synonyms ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5
ACCN NM_033355
Insert Size 1158 bp
Sequence Data
>SC212572 3'UTR clone of NM_033355
The sequence shown below is from the reference sequence of NM_033355. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon


CAATTGGCAGAGCTCAGAATTCAAGCGATCGC

AGCCTACTTTCACACTAAGAAAAAAACTTGTCTTCCCTTCTGATTGATGGTGCTATTTTGTTTGTTTTGT
TTTGTTTTGTTTTTTTGAGACAGAATCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGC
TCACCGCAAGCTCCGCCTCCCGGGTTCAGGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACA
GGGGCCCGCCACCACACCTGGCTAATTTTTTAAAAATATTTTTAGTAGAGACAGGGTTTCACTGTGTTAG
CCAGGGTGGTCTTGATCTCCTGACCTCGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGG
CGTGAGCCACCGCGCCTGGCCGATGGTACTATTTAGATATAACACTATGTTTATTTACTAATTTTCTAGA
TTTTCTACTTTATTAATTGTTTTGCACTTTTTTATAAGAGCTAAAGTTAAATAGGATATTAACAACAATA
ACACTGTCTCCTTTCTCTTATGCTTAAGGCTTTGGGAATGTTTTTAGCTGGTGGCAATAAATACCAGACA
CGTACAAAATCCAGCTATGAATATAGAGGGCTTATGATTCAGATTGTTATCTATCAACTATAAGCCCACT
GTTAATATTCTATTAACTTTAATTCTCTTTCAAAGCTAAATTCCACACTACCACATTAAAAAAATTAGAA
AGTAGCCACGTATGGTGGCTCATGTCTATAATCCCAGCACTTTGGGAGGTTGAGGTGGGAGGATTGCTTG
AACCCAAGAGGTCAAGGCTGCAGTGAGCCATGTTCACACCGCTGCACTCAAGCTTGGGTGACAGAACAAG
ACCCCGTCTCAAAAAAAATTTTTTTTTTAATAAAACAAAATTTGTTTGAAATCTTTTAAAAATTCAAATG
ATTTTTACAAGTTTTAAATAAGCTCTCCCCAAACTTGCTTTATGCCTTCTTATTGCTTTTATGATATATA
TATGCTTGGCTAACTATATTTGCTTTTTGCTAACAATGCTCTGGGGTCTTTTTATGCATTTGCATTTGCT
CTTTCATCTCTGCTTGGATTATTTTAAATCATTAGGAATTAAGTTATCTTTAAAATTTAAGTATCTTTTT
TCAAAAACATTTTTTAATAGAATAAAATATAATTTGAT

ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
Restriction Sites SgfI-MluI     
OTI Disclaimer Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as 10 ug dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials.
Reference Data
RefSeq NM_033355.3
Summary 'This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]'
Locus ID 841

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.