FBXO11 (NM_025133) Human 3' UTR Clone

CAT#: SC213230

3`UTR clone of F-box protein 11 (FBXO11) transcript variant 1 for miRNA target validation


Reconstitution Protocol

USD 560.00

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Size
    • 10 ug

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Specifications

Product Data
Vector pMirTarget
Species Human
Transfection Reporter RFP
Assay Reporter Luciferase
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Symbol FBXO11
Synonyms FBX11; IDDFBA; PRMT9; UBR6; UG063H01; VIT1
ACCN NM_025133
Insert Size 1216
Sequence Data
>SC213230 3'UTR clone of NM_025133
The sequence shown below is from the reference sequence of NM_025133. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon


CAATTGGCAGAGCTCAGAATTCAAGCGATCGC

TGACTCTGCTCCACCTATAGAATCTAATACATTGCAGCACAACTGAATTCCTTCCCTAAAGAAAAAGTCC
TGCCATTGTAACATCATAACTTAAAACACTTTTTTGGAAGAAGATTTAAAATATTTGCCCATGCTACAGG
AAGAGACTGTATTAAAAATGGATACACAAGGTCAGTTGACACTATGAAGCTCAAGCTACCAAAAAGAAAG
TGGCAATATATTGACTCAGGATCTCAAAGCTGGGTGTTTTAGCATTACTGTGTAAAGACTTGAAGGGACA
GAAGTGAAGAAAATAAGCTGCAATTTTGTACAGATACCAACTTCTGAAAAGCTGGTGTTTTTACAACTAG
CATTGAATGCAGTCCAATTTGCAGTAGTAATCTTCAATAGACAAGCAGCTTTGTTGCTGCCTTTATGGAC
ATGGGTACCAATTGCTTTTGTAATATGGTAAAAATGTGAGCTAGCACTTCTGCGTTCCTTTTGATTTTTT
TTTTTTAACATGTATTCAGATTGAGAAATATGATTTTAATGCTTTAATCTCATGTAGTTTGTTTTTAATT
TCAAGCAAAATCTTACTGTACTTGAATGTGCCCTGTTTTGTTAGCACACCTAGACTTGCTGTAACTGTAC
TCATGTCCCAGTATGTACGTTCTTTCTATGAAAGAGAAAACACTAATCTTAAATTATATCCAGCAATGTT
TCTGGTATCCTTTAAGAAAAGTTAAGACTATTATTTCCTTCCCTTCCCTGTGCAGCATTCAAAATCACCC
CTAGAAAAAGTGAGTGTTTTAATGAGACTTCCTAGGAAGGGATGCACTGTAAAACAAAAGTATTCTTGTA
ACTCAGTTTTGTGAAAGGTAAAAAACTACTATGTTTTAAGTACACTTTAGAAAGTCTCTTCAAAACAAAC
AGTCCTGTATTTGAACTCTGTTCATAGTTTTTTTTTGAACAGTTTAGACAAAACTGCTGGAAATTAAACC
AATTTCCTGCATTAAGCTGAGACAAGTATATATACAGCCCTATACAGTTTCATAGCTTTTCCTCCCCCAT
TTATGTGTATTGGTGACAGTGGGTATAAAACAGCCTGAAAGTGTATGCATGTACCATAACATCTAGACTT
AATATATTGTGGAGTATTCAATAACCATTATGTAGAAGGTAGATAAGAATTAAAAGGGTTTAATTTCCTA
GAAAGAAAATGGAAAAATGGTCATTT

ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
Restriction Sites SgfI-MluI     
OTI Disclaimer Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq NM_025133.3
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
Locus ID 80204

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