MRP5 (ABCC5) (NM_001023587) Human 3' UTR Clone

CAT#: SC213255

3`UTR clone of ATP-binding cassette sub-family C (CFTR/MRP) member 5 (ABCC5) transcript variant 2 for miRNA target validation

Specifications

Product Data

• Vector: pMirTarget
• Species: Human
• Transfection Reporter: RFP
• Assay Reporter: Luciferase
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Symbol: ABCC5
• Synonyms: ABC33; EST277145; MOAT-C; MOATC; MRP5; pABC11; SMRP
• ACCN: NM_001023587
• Insert Size: 1206
• Sequence Data:
  Insert Sequence

  >SC213255 3'UTR clone of NM_001023587
  The sequence shown below is from the reference sequence of NM_001023587. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon
  
  
  CAATTGGCAGAGCTCAGAATTCAAGCGATCGC
  
  GATGGCTGTATTCTGCGGTCAGAATGAGAGAGTCAAGCTGGGCAGAATCTCTCGCCAAGAGTTCAGCCTT
  CCTTTGGAGACTGCTCCATCAGTGCCGAGGTGTGTGGGAACAGGCTTCACTGCACCGCCATCTTACTGAG
  TTGCTTCACGTGAGGAAAAGGGGGCTTTGGCCCTGTGACTCAGTTCCACATTTTGGATTGCATACTGGAA
  AAGAAGCCAATCTTCTTGCTAGTAAACCAGCAACCCGGCTGTATACAGTGGTGACCCAAGCAATGGATAT
  AAACCTAAAAATCTGAGGGAGGGGAGAGGTGGAATACAGTAGTTCTTGGAATCTGAAGTCTCCTATTTGA
  TCAGGTTATTTCCTGGGACTTGGCAAAAATCTGATTGGTGGGGATCTCCTAGGACCTAGTGGACATCTGG
  TATTAATTTAATCTCAGGAAAAACAAGAAATTAACCCAGAGAGAGTCTGGGTTTTGGAATTCAGCGTAGC
  TACCTCCAGACCGTGGTGTCTGGCCTCCATTTTTGTCTGTCATTCAGCTCTGACTTACAGCTGCAGTCAC
  CTTTGCTATAAGGCACCTGGGTAGAAGGGTGGATGGGCTTCACATCAATTTTTTTCTTCCTTTAGGGTGG
  GGGATTGGTTTGGCTTTCTTTTGTTGTGGTTTTTTGTTTTATTTTTGTCAAGATTGATTTTTAGATGCAA
  GGACTTGAAAAGACCCAGAAGGATGCCACCAGTTTTTCCTTGAGGCCTAGGATTTTTTATTCTGTCCCGA
  GCAGAGGTAATTCCTCACAACTTAGTGCACCAGTAGCACCAGCCATTTTGAGCAGAGTACCTCTTTGGGG
  AGCTTTTCGTTTTGTTTTGTTTTTAATTCTCTTTCCTTAGCAGCAAGGTCTTTTTTCCTAGAGAATCTAC
  TCCGTTGCAGAATCATTGCAACCTCAGGAGCCCTCACTGATTGAGTGCTGTCAGCCTGATATACTACTTT
  GGACTCTGGAAACAGATATGGGTTCTATTCTCTATTTCTACTGTGTGTCGTTAAACAACCGTCGGAGACC
  AGATGACCTGTTAGATGGCTAGTCCTGTATAACTCGACTCTGTATGTTTCAATGTATGTTACTGCAATGC
  TTCACCTGCTGTACAGTGTTTGTGAGATGCTCTTTGAAGATGGTACTTTTATATTTTTTCATTTTCAATA
  AAAGTACATTCCTTCC
  
  ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
• Restriction Sites: SgfI-MluI
• OTI Disclaimer: Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).

Reference Data

• RefSeq: NM_001023587.1
• Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
• Locus ID: 10057