MRP5 (ABCC5) (NM_005688) Human 3' UTR Clone

CAT#: SC214211

3`UTR clone of ATP-binding cassette sub-family C (CFTR/MRP) member 5 (ABCC5) transcript variant 1 for miRNA target validation

Specifications

Product Data

• Vector: pMirTarget
• Species: Human
• Transfection Reporter: RFP
• Assay Reporter: Luciferase
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Symbol: ABCC5
• Synonyms: ABC33; EST277145; MOAT-C; MOATC; MRP5; pABC11; SMRP
• ACCN: NM_005688
• Insert Size: 1366
• Sequence Data:
  Insert Sequence

  >SC214211 3'UTR clone of NM_005688
  The sequence shown below is from the reference sequence of NM_005688. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon
  
  
  CAATTGGCAGAGCTCAGAATTCAAGCGATCGC
  
  GAGAACAAGGTCGCTGTCAAGGGCTGACTCCTCCCTGTTGACGAAGTCTCTTTTCTTTAGAGCATTGCCA
  TTCCCTGCCTGGGGCGGGCCCCTCATCGCGTCCTCCTACCGAAACCTTGCCTTTCTCGATTTTATCTTTC
  GCACAGCAGTTCCGGATTGGCTTGTGTGTTTCACTTTTAGGGAGAGTCATATTTTGATTATTGTATTTAT
  TCCATATTCATGTAAACAAAATTTAGTTTTTGTTCTTAATTGCACTCTAAAAGGTTCAGGGAACCGTTAT
  TATAATTGTATCAGAGGCCTATAATGAAGCTTTATACGTGTAGCTATATCTATATATAATTCTGTACATA
  GCCTATATTTACAGTGAAAATGTAAGCTGTTTATTTTATATTAAAATAAGCACTGTGCTAATAACAGTGC
  ATATTCCTTTCTATCATTTTTGTACAGTTTGCTGTACTAGAGATCTGGTTTTGCTATTAGACTGTAGGAA
  GAGTAGCATTTCATTCTTCTCTAGCTGGTGGTTTCACGGTGCCAGGTTTTCTGGGTGTCCAAAGGAAGAC
  GTGTGGCAATAGTGGGCCCTCCGACAGCCCCCTCTGCCGCCTCCCCACGGCCGCTCCAGGGGTGGCTGGA
  GACGGGTGGGCGGCTGGAGACCATGCAGAGCGCCGTGAGTTCTCAGGGCTCCTGCCTTCTGTCCTGGTGT
  CACTTACTGTTTCTGTCAGGAGAGCAGCGGGGCGAAGCCCAGGCCCCTTTTCACTCCCTCCATCAAGAAT
  GGGGATCACAGAGACATTCCTCCGAGCCGGGGAGTTTCTTTCCTGCCTTCTTCTTTTTGCTGTTGTTTCT
  AAACAAGAATCAGTCTATCCACAGAGAGTCCCACTGCCTCAGGTTCCTATGGCTGGCCACTGCACAGAGC
  TCTCCAGCTCCAAGACCTGTTGGTTCCAAGCCCTGGAGCCAACTGCTGCTTTTTGAGGTGGCACTTTTTC
  ATTTGCCTATTCCCACACCTCCACAGTTCAGTGGCAGGGCTCAGGATTTCGTGGGTCTGTTTTCCTTTCT
  CACCGCAGTCGTCGCACAGTCTCTCTCTCTCTCTCCCCTCAAAGTCTGCAACTTTAAGCAGCTCTTGCTA
  ATCAGTGTCTCACACTGGCGTAGAAGTTTTTGTACTGTAAAGAGACCTACCTCAGGTTGCTGGTTGCTGT
  GTGGTTTGGTGTGTTCCCGCAAACCCCCTTTGTGCTGTGGGGCTGGTAGCTCAGGTGGGCGTGGTCACTG
  CTGTCATCAATTGAATGGTCAGCGTTGCATGTCGTGACCAACTAGACATTCTGTCGCCTTAGCATGTTTG
  CTGAACACCTTGTGGAAGCAAAAATCTGAAAATGTG
  
  ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
• Restriction Sites: SgfI-MluI
• OTI Disclaimer: Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).

Reference Data

• RefSeq: NM_005688.2
• Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
• Locus ID: 10057