FURIN (NM_002569) Human 3' UTR Clone

CAT#: SC215432

3`UTR clone of furin (paired basic amino acid cleaving enzyme) (FURIN) for miRNA target validation

Reconstitution Protocol

USD 670.00

4 Weeks*

Size
    • 10 ug

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Specifications

Product Data
Vector pMirTarget
Species Human
Transfection Reporter RFP
Assay Reporter Luciferase
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Symbol FURIN
Synonyms FUR; PACE; PCSK3; SPC1
ACCN NM_002569
Insert Size 1613 bp
Sequence Data
>SC215432 3'UTR clone of NM_002569
The sequence shown below is from the reference sequence of NM_002569. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon


CAATTGGCAGAGCTCAGAATTCAAGCGATCGC

GCGAGAGGACCGCCTTTATCAAAGACCAGAGCGCCCTCTGATGAGCCCACTGCCCACCCCCTCAAGCCAA
TCCCCTCCTTGGGCACTTTTTAATTCACCAAAGTATTTTTTTATCTTGGGACTGGGTTTGGACCCCAGCT
GGGAGGCAAGAGGGGTGGAGACTGCTTCCCATCCTACCCTCGGGCCCACCTGGCCACCTGAGGTGGGCCC
AGGACCAGCTGGGGCGTGGGGAGGGCCGTACCCCACCCTCAGCACCCCTTCCATGTGGAGAAAGGAGTGA
AACCTTTAGGGCAGCTTGCCCCGGCCCCGGCCCCAGCCAGAGTTCCTGCGGAGTGAAGAGGGGCAGCCCT
TGCTTGTTGGGATTCCTGACCCAGGCCGCAGCTCTTGCCCTTCCCTGTCCCTCTAAAGCAATAATGGTCC
CATCCAGGCAGTCGGGGGCTGGCCTAGGAGATATCTGAGGGAGGAGGCCACCTCTCCAAGGGCTTCTGCA
CCCTCCACCCTGTCCCCCAGCTCTGGTGAGTCTTGGCGGCAGCAGCCATCATAGGAAGGGACCAAGGCAA
GGCAGGTGCCTCCAGGTGTGCACGTGGCATGTGGCCTGTGGCCTGTGTCCCATGACCCACCCCTGTGCTC
CGTGCCTCCACCACCACTGGCCACCAGGCTGGCGCAGCCAAGGCCGAAGCTCTGGCTGAACCCTGTGCTG
GTGTCCTGACCACCCTCCCCTCTCTTGCACCCGCCTCTCCCGTCAGGGCCCAAGTCCCTGTTTTCTGAGC
CCGGGCTGCCTGGGCTGTTGGCACTCACAGACCTGGAGCCCCTGGGTGGGTGGTGGGGAGGGGCGCTGGC
CCAGCCGGCCTCTCTGGCCTCCCACCCGATGCTGCTTTCCCCTGTGGGGATCTCAGGGGCTGTTTGAGGA
TATATTTTCACTTTGTGATTATTTCACTTTAGATGCTGATGATTTGTTTTTGTATTTTTAATGGGGGTAG
CAGCTGGACTACCCACGTTCTCACACCCACCGTCCGCCCTGCTCCTCCCTGGCTGCCCTGGCCCTGAGGT
GTGGGGGCTGCAGCATGTTGCTGAGGAGTGAGGAATAGTTGAGCCCCAAGTCCTGAAGAGGCGGGCCAGC
CAGGCGGGCTCAAGGAAAGGGGGTCCCAGTGGGAGGGGCAGGCTGACATCTGTGTTTCAAGTGGGGCTCG
CCATGCCGGGGGTTCATAGGTCACTGGCTCTCCAAGTGCCAGAGGTGGGCAGGTGGTGGCACTGAGCCCC
CCCAACACTGTGCCCTGGTGGAGAAAGCACTGACCTGTCATGCCCCCCTCAAACCTCCTCTTCTGACGTG
CCTTTTGCACCCCTCCCATTAGGACAATCAGTCCCCTCCCATCTGGGAGTCCCCTTTTCTTTTCTACCCT
AGCCATTCCTGGTACCCAGCCATCTGCCCAGGGGTGCCCCCTCCTCTCCCATCCCCCTGCCCTCGTGGCC
AGCCCGGCTGGTTTTGTAAGATGCTGGGTTGGTGCACAGTGATTTTTTTCTTGTAATTTAAACAGGCCCA
GCATTGCTGGTTCTATTTAATGGACATGAGATAATGTTAGAGGTTTTAAAGTGATTAAACGTGCAGACTA
TGC

ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
Restriction Sites SgfI-MluI     
OTI Disclaimer Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as 10 ug dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials.
Reference Data
RefSeq NM_002569.2
Summary 'This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. Like other members of this convertase family, the product of this gene specifically cleaves substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140, and may play a role in tumor progression. Unlike SARS-CoV and other coronaviruses, the spike protein of SARS-CoV-2 is thought to be uniquely cleaved by this protease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]'
Locus ID 5045

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.