LIM kinase 2 (LIMK2) (NM_005569) Human 3' UTR Clone
CAT#: SC215764
3`UTR clone of LIM domain kinase 2 (LIMK2) transcript variant 2a for miRNA target validation
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Specifications
Product Data | |
Vector | pMirTarget |
Species | Human |
Transfection Reporter | RFP |
Assay Reporter | Luciferase |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Symbol | LIMK2 |
ACCN | NM_005569 |
Insert Size | 1652 bp |
Sequence Data |
>SC215764 3'UTR clone of NM_005569
The sequence shown below is from the reference sequence of NM_005569. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon CAATTGGCAGAGCTCAGAATTCAAGCGATCGC CTGTGAGCATGCAGTACGGCCTGACCCGGGACTCACCTCCCTAGCCCTGGCCCAGCCCCCTGCAGGGGGG TGTTCTACAGCCAGCATTGCCCCTCTGTGCCCCATTCCTGCTGTGAGCAGGGCCGTCCGGGCTTCCTGTG GATTGGCGGAATGTTTAGAAGCAGAACAAGCCATTCCTATTACCTCCCCAGGAGGCAAGTGGGCGCAGCA CCAGGGAAATGTATCTCCACAGGTTCTGGGGCCTAGTTACTGTCTGTAAATCCAATACTTGCCTGAAAGC TGTGAAGAAGAAAAAAACCCCTGGCCTTTGGGCCAGGAGGAATCTGTTACTCGAATCCACCCAGGAACTC CCTGGCAGTGGATTGTGGGAGGCTCTTGCTTACACTAATCAGCGTGACCTGGACCTGCTGGGCAGGATCC CAGGGTGAACCTGCCTGTGAACTCTGAAGTCACTAGTCCAGCTGGGTGCAGGAGGACTTCAAGTGTGTGG ACGAAAGAAAGACTGATGGCTCAAAGGGTGTGAAAAAGTCAGTGATGCTCCCCCTTTCTACTCCAGATCC TGTCCTTCCTGGAGCAAGGTTGAGGGAGTAGGTTTTGAAGAGTCCCTTAATATGTGGTGGAACAGGCCAG GAGTTAGAGAAAGGGCTGGCTTCTGTTTACCTGCTCACTGGCTCTAGCCAGCCCAGGGACCACATCAATG TGAGAGGAAGCCTCCACCTCATGTTTTCAAACTTAATACTGGAGACTGGCTGAGAACTTACGGACAACAT CCTTTCTGTCTGAAACAAACAGTCACAAGCAAAGGAAGAGGCTGGGGGACTAGAAAGAGGCCCTGCCCTC TAGAAAGCTCAGATCTTGGCTTCTGTTACTCATACTCGGGTGGGCTCCTTAGTCAGATGCCTAAAACATT TTGCCTAAAGCTCGATGGGTTCTGGAGGACAGTGTGGCTTGTCACAGGCCTAGAGTCTGAGGGAGGGGAG TGGGAGTCTCAGCAATCTCTTGGTCTTGGCTTCATGGCAACCACTGCTCACCCTTCAACATGCCTGGTTT AGGCAGCAGCTTGGGCTGGGAAGAGGTGGTGGCAGAGTCTCAAAGCTGAGATGCTGAGAGAGATAGCTCC CTGAGCTGGGCCATCTGACTTCTACCTCCCATGTTTGCTCTCCCAACTCATTAGCTCCTGGGCAGCATCC TCCTGAGCCACATGTGCAGGTACTGGAAAACCTCCATCTTGGCTCCCAGAGCTCTAGGAACTCTTCATCA CAACTAGATTTGCCTCTTCTAAGTGTCTATGAGCTTGCACCATATTTAATAAATTGGGAATGGGTTTGGG GTATTAATGCAATGTGTGGTGGTTGTATTGGAGCAGGGGGAATTGATAAAGGAGAGTGGTTGCTGTTAAT ATTATCTTATCTATTGGGTGGTATGTGAAATATTGTACATAGACCTGATGAGTTGTGGGACCAGATGTCA TCTCTGGTCAGAGTTTACTTGCTATATAGACTGTACTTATGTGTGAAGTTTGCAAGCTTGCTTTAGGGCT GAGCCCTGGACTCCCAGCAGCAGCACAGTTCAGCATTGTGTGGCTGGTTGTTTCCTGGCTGTCCCCAGCA AGTGTAGGAGTGGTGGGCCTGAACTGGGCCATTGATCAGACT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG |
Restriction Sites | SgfI-MluI |
OTI Disclaimer | Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs). |
Product Components | The cDNA clone is shipped in a 2-D bar-coded Matrix tube as 10 ug dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. |
Reference Data | |
RefSeq | NM_005569.3 |
Summary | 'There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]' |
Locus ID | 3985 |
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