Tgfb1 (BC013738) Mouse Untagged Clone

CAT#: MC200640

Tgfb1 (untagged) - Mouse transforming growth factor, beta 1 (cDNA clone MGC:5747 IMAGE:3586216), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Tgfb1
• Synonyms: TGF-beta1
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC013738
  GGACCCTCTCTCCCCCGAGAGGCAGATCTCCCTCGGACCTGCTGGCAGTAGCTCCCCTATTTAAGAACAC CCACTTTTGGATCTCAGAGAGCGCTCATCTCGATTTTTACCCTGGTGGTATACTGAGACACCTTGGTGTC AGAGCCTCACCGCGACTCCTGCTGCTTTCTCCCTCAACCTCAAATTATTCAGGACTATCACCTACCTTTC CTTGGGAGACCCCACCCCACAAGCCCTGCAGGGGCGGGGCCTCCGCATCCCACCTTTGCCGAGGGTTCCC GCTCTCCGAAGTGCCGTGGGGCGCCGCCTCCCCCATGCCGCCCTCGGGGCTGCGGCTACTGCCGCTTCTG CTCCCACTCCCGTGGCTTCTAGTGCTGACGCCCGGGAGGCCAGCCGCGGGACTCTCCACCTGCAAGACCA TCGACATGGAGCTGGTGAAACGGAAGCGCATCGAAGCCATCCGTGGCCAGATCCTGTCCAAACTAAGGCT CGCCAGTCCCCCAAGCCAGGGGGAGGTACCGCCCGGCCCGCTGCCCGAGGCGGTGCTCGCTTTGTACAAC AGCACCCGCGACCGGGTGGCAGGCGAGAGCGCCGACCCAGAGCCGGAGCCCGAAGCGGACTACTATGCTA AAGAGGTCACCCGCGTGCTAATGGTGGACCGCAACAACGCCATCTATGAGAAAACCAAAGACATCTCACA CAGTATATATATGTTCTTCAATACGTCAGACATTCGGGAAGCAGTGCCCGAACCCCCATTGCTGTCCCGT GCAGAGCTGCGCTTGCAGAGATTAAAATCAAGTGTGGAGCAACATGTGGAACTCTACCAGAAATATAGCA ACAATTCCTGGCGTTACCTTGGTAACCGGCTGCTGACCCCCACTGATACGCCTGAGTGGCTGTCTTTTGA CGTCACTGGAGTTGTACGGCAGTGGCTGAACCAAGGAGACGGAATACAGGGCTTTCGATTCAGCGCTCAC TGCTCTTGTGACAGCAAAGATAACAAACTCCACGTGGAAATCAACGGGATCAGCCCCAAACGTCGGGGCG ACCTGGGCACCATCCATGACATGAACCGGCCCTTCCTGCTCCTCATGGCCACCCCCCTGGAAAGGGCCCA GCACCTGCACAGCTCACGGCACCGGAGAGCCCTGGATACCAACTATTGCTTCAGCTCCACAGAGAAGAAC TGCTGTGTGCGGCAGCTGTACATTGACTTTAGGAAGGACCTGGGTTGGAAGTGGATCCACGAGCCCAAGG GCTACCATGCCAACTTCTGTCTGGGACCCTGCCCCTATATTTGGAGCCTGGACACACAGTACAGCAAGGT CCTTGCCCTCTACAACCAACACAACCCGGGCGCTTCGGCGTCACCGTGCTGCGTGCCGCAGGCTTTGGAG CCACTGCCCATCGTCTACTACGTGGGTCGCAAGCCCAAGGTGGAGCAGTTGTCCAACATGATTGTGCGCT CCTGCAAGTGCAGCTGAAGCCCCGCCCCGCCCCGCCCCTCCCGGCAGGCCCGGCCCCGCCCCCGCCCCGC CCGCAGCGCCCGGGGCTGTATTTAAGGACACCTGCACCCCCCCTCAAGCCCACCTGGGGGGCCCATTAAA GGTGACAGAGGAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: RsrII-NotI
• ACCN: BC013738
• ORF Size: 1173 bp
• Insert Size: 1173
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: BC013738, AAH13738
• RefSeq Size: 1641
• RefSeq ORF: 1173
• Locus ID: 21803
• Gene Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. Mice lacking a functional copy of this gene develop severe multifocal inflammatory disease, yolk sac defects and colon cancer. [provided by RefSeq, Aug 2016]