Kpna2 (NM_010655) Mouse Untagged Clone

CAT#: MC200772

Kpna2 (untagged) - Mouse karyopherin (importin) alpha 2 (Kpna2), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Kpna2
• Synonyms: 2410044B12Rik; IPOA1; PTAC58; Rch1
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC006720 sequence for NM_010655
  GAAGGGTAGCAGACGTTTCCACAGCCGCCGACCCGCAGCTTGAGTGTCCTGCACCACCTTTCGTGGAAAT CTGAGCCGGCTGTACAGCTTTCCTCCTTGTTCCTGCAGCCATGTCCACGAACGAGAATGCTAACTTACCA GCTGCCCGACTTAACAGGTTCAAGAACAAGGGGAAGGACAGCACAGAAATGCGTCGCCGCCGAATAGAAG TTAATGTGGAACTCAGGAAAGCTAAAAAAGATGAGCAGATGCTGAAAAGAAGAAACGTCAGCTCCTTTCC TGATGATGCTACTTCTCCGCTACAGGAAAACCGGAACAACCAGGGTACTGTAAATTGGTCTGTTGAGGAC ATTGTTAAAGGCATAAACAGTAACAATTTGGAAAGCCAGCTCCAAGCTACTCAAGCTGCTCGGAAATTGC TTTCTAGAGAGAAACAGCCTCCTATAGACAACATCATCCGGGCTGGTTTGATCCCAAAATTTGTGTCCTT CTTGGGCAAAACTGATTGTAGTCCTATTCAGTTTGAGTCTGCTTGGGCACTCACCAACATTGCTTCTGGA ACATCTGAACAGACCAAAGCTGTGGTGGATGGAGGTGCTATCCCAGCGTTTATTTCTCTCTTGGCATCTC CTCATGCTCACATCAGCGAGCAAGCTGTTTGGGCTCTTGGAAACATTGCAGGTGATGGTTCAGCTTTCCG AGACTTAGTTATCAAACACGGTGCGATTGACCCACTGTTGGCACTTCTTGCAGTTCCCGATCTGTCTACC TTGGCATGTGGTTACTTACGTAATCTTACCTGGACGCTTTCAAACCTTTGTCGAAACAAGAACCCTGCAC CTCCCTTAGATGCCGTTGAGCAGATTCTTCCTACGTTAGTTCGACTCCTGCACCACAATGATCCAGAAGT ATTGGCAGATTCCTGCTGGGCCATTTCCTACCTGACTGATGGTCCAAATGAGCGCATTGAGATGGTTGTG AAGAAAGGAGTTGTTCCCCAACTTGTGAAGCTTCTAGGAGCTACTGAACTGCCCATTGTGACTCCCGCAC TAAGAGCCATAGGGAATATTGTCACTGGAACAGATGAGCAGACTCAGAAAGTGATCGATGCAGGAGCACT TGCAGTCTTTCCCAGCCTGCTAACAAACCCCAAAACTAATATTCAGAAGGAGGCCACATGGACAATGTCG AACATTACAGCTGGACGCCAGGACCAGATACAGCAAGTTGTGAATCACGGCCTAGTCCCCTTTCTTGTTG GTGTCCTCTCTAAGGCGGACTTTAAGACACAGAAGGAGGCCGCGTGGGCTATAACCAACTATACCAGCGG TGGGACTGTTGAGCAGATTGTGTATCTCGTTCACTGTGGGATAATAGAACCTTTGATGAACCTCCTGAGT GCAAAAGATACCAAGATTATTCAGGTTATTCTTGACGCCATTTCAAATATCTTTCAGGCTGCAGAGAAAC TAGGTGAGACAGAAAAGCTTAGTATAATGATTGAAGAGTGTGGAGGCTTGGATAAAATTGAAGCACTACA GAGGCATGAAAACGAGTCTGTATACAAGGCCTCATTGAACTTAATTGAGAAGTACTTCTCAGTGGAGGAA GAGGAAGATCAAAATGTGGTGCCAGAAACTACCTCTGAAGGCTTCGCCTTCCAAGTTCAGGATGGAGCTC CTGGGACCTTTAACTTCTAATGTCCAGCTAAGGCACAAAGTTGTTAGCTATGTGCTGTGCTATTCTGTGT TCTCATAGATTTGTCTTACTGTTTCTCTACTAAGAACTCTTTTTAAATGTGGTTTGTTATTGTAGCACTT TTTACAAAAGAAACTATACTTGAACAGTTATAAACTGTACATACTCTATGAAGCTGTCCTCTGAATTTAT TTCTATGTGGAATTTCGTACCCTGTCATGTCCTGTAAATAAAGATTAAAGTTCCATTCTTTAAAAAAAAA AAAAAAAAAAAAAAAAA
• Restriction Sites: RsrII-NotI
• ACCN: NM_010655
• ORF Size: 1590 bp
• Insert Size: 1590
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: BC006720, AAH06720
• RefSeq Size: 1977
• RefSeq ORF: 1590
• Locus ID: 16647
• Gene Summary: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [UniProtKB/Swiss-Prot Function]