Gpx2 (NM_030677) Mouse Untagged Clone

CAT#: MC202331

Gpx2 (untagged) - Mouse glutathione peroxidase 2 (Gpx2), (10ug), (Note: selenocysteine protein, Internal stop codon present. see reference data summary below)


  "NM_030677" in other vectors (4)

Reconstitution Protocol

USD 210.00

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Size
    • 10 ug

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Specifications

Product Data
Type Mouse Untagged Clone
Symbol Gpx2
Synonyms GI-GPx; GPx-GI; GSHPx-2; GSHPx-GI
Vector PCMV6-Kan/Neo
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>BC034335 sequence for NM_030677
CAGGGCAGGGCTCACTGCTCTTCAGCATGGCTTACATTGCCAAGTCGTTCTACGATCTCAGTGCCATTGG CCTGGATGGGGAGAAGATAGACTTCAATACGTTCAGAGGCAGGGCTGTGCTGATTGAGAATGTGGCGTCA CTCTGAGGAACAACTACCCGGGACTACAACCAGCTCAATGAGCTGCAATGTCGCTTTCCCAGGCGCCTGG TAGTTCTCGGCTTCCCTTGCAACCAGTTCGGACATCAGGAGAACTGTCAGAACGAGGAGATCCTGAACAG CCTCAAGTATGTCCGACCTGGGGGTGGGTACCAGCCCACCTTTAGTCTTACCCAAAAGTGTGACGTCAAT GGGCAGAACGAGCATCCTGTCTTTGCCTACCTGAAAGACAAGCTGCCCTACCCTTATGATGACCCGTTCT CCCTCATGACCGATCCCAAGCTCATCATATGGAGTCCCGTGCGCCGCTCAGACGTGTCCTGGAACTTTGA GAAGTTCCTCATAGGGCCAGAAGGGGAGCCCTTCCGTCGCTACAGCCGCAGCTTCCAGACCATCAACATC GAGCCTGACATCAAACGGCTCCTCAAAGTTGCCATCTAGATGAGAGCTGCTCAGCCCAGGAATCTCCCAC TGTTTCCCCTGAGCAGTCTTCCTCAGGGCTCAGTGTACCCTCGGGAGACCCTGGGAGACCAAGGCATTCC CTGAATATCGTCCCCTTGCCTTCCCTACCGGCCATTTCCTTTAGCTCCCTCAAGGCTCTTGGGGAGTTTG CTTGGGGCTCTAAGTCTGGGGTAGGTTCTGGGCCTTCACAGAATGATGGCATCTTCCTAAACCCTTCTGG GAGATGTCTGAGAAGTTGTGAAGGGTCCAGAGCCAGTCTGCTTTAGAGTCCAATAAAGTGTAGGTGTGGC AAAAAAAAAAAAAAAAAAAAAAAAAAAA
Restriction Sites RsrII-NotI     
ACCN NM_030677
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). The expression of this clone is not guaranteed due to the nature of selenoproteins.
OTI Annotation This clone encodes a selenoprotein containing the rare amino acid selenocysteine (Sec). Sec is encoded by UGA codon, which normally signals translational termination. Expression of this clone is not guaranteed due to the nature of selenoproteins.
Reference Data
RefSeq BC034335, AAH34335
RefSeq Size 938
Locus ID 14776
Gene Summary The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract in rodents, is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Knockout studies in mice lacking this gene suggest a role for this isozyme in intestinal inflammation and colon cancer development. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A pseudogene of this locus has been identified on chromosome 7. [provided by RefSeq, Aug 2017]

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