Cldn5 (NM_013805) Mouse Untagged Clone

CAT#: MC202457

Cldn5 (untagged) - Mouse claudin 5 (Cldn5), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Cldn5
• Synonyms: AI854493; MBEC1; Tmvcf
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC083341 sequence for NM_013805
  GTTAAAACCTCCTCTTCTGCTCCAGGACTGGAGGCTCCAGAGCAGAGGCACCAGAATCAATTCCCAGCTC CCAGCCTAAGCAGCGCAGAGAGCACCCGGAGGCCCCAAGGGCCGTCGGGTGAGCATTCAGTCTTTAGCCA TGGGGTCTGCAGCGTTGGAAATTCTGGGTCTGGTGCTGTGTCTGGTAGGATGGGTGGGCTTGATCCTGGC GTGTGGGCTGCCCATGTGGCAGGTGACTGCCTTCCTGGACCACAACATCGTGACGGCGCAGACGACTTGG AAGGGGCTGTGGATGTCGTGCGTGGTGCAGAGTACCGGGCACATGCAGTGCAAGGTGTATGAATCTGTGC TGGCGCTGAGTGCGGAGGTGCAGGCAGCTCGGGCACTCACCGTGGGCGCTGTGCTGCTGGCGCTGGTGGC ACTCTTTGTTACCTTGACCGGCGCTCAGTGCACCACCTGCGTGGCCCCGGGCCCAGTTAAGGCACGGGTA GCACTCACGGGAGGAGCGCTTTACGCGGTGTGCGGGCTGCTGGCACTCGTGCCGCTCTGCTGGTTCGCCA ACATCGTTGTCCGCGAGTTCTATGATCCGACGGTGCCGGTGTCACAGAAGTACGAGCTGGGCGCGGCGCT GTACATCGGCTGGGCGGCCTCCGCACTGCTCATGTGCGGTGGCGGCCTCGTGTGTTGCGGCGCCTGGGTC TGCACCGGGCGCCCTGAGTTCAGCTTCCCGGTCAAGTACTCTGCGCCGCGGCGGCCCACGGCCAATGGCG ATTACGACAAGAAGAACTATGTCTAAGGGCGGGAGGCATGGCGGGGCTCTTCCCGCAGCTAAGCCCGCGA TGGGAAAGACCGATGCGGGAAGCCGTGTGTGGATGACGACCACCGCTGGGTTGCGCAGCGCAAGTCATGC TGGGTTCGGGCCAGACTTGCCCGCTCTCAGAGTCCGTTGACCATCACTAGCCGGGCCCTGCTCAGAACAG ACTACAGGCACTTTTAAGAACTTGACCGACCTTTTCTTCTATGCGCAGTTGGCCACGACGTGGGTGGAAC GCTCAGATTTCATCGGTGAAGTAGGCACCAAACTGCCGCGAACAGTTCCTACTGAGATCCTGGGGGCACT AGATGCTGCCTTAATGTCCAGTGGCACCTGCTAACCTGAAAGGGCAGCTGGAGAAACCCCGGGGCTGCCA GAGGGACGTGTTAAAAAGGGCATTTTCTTTGTTAGTGGAGAAGAACCTACTGAACCAAAGGACTTAGCCT GGACCTGGTCTCACTCCAGCACTCCCCCAAGGTGGGGGCCCTGTAGGTACCAGAGCCTTAGAGGGGTTGC CTTCCTCCTGGAAGCTTGGGGCTTGGGGGGTGGGCCGGGCAAGAATTTGCTCAGTAAATGGTTTGAACAC TTTAAAAAAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: AscI-NotI
• ACCN: NM_013805
• ORF Size: 657 bp
• Insert Size: 657
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: BC083341, AAH83341
• RefSeq Size: 1428
• RefSeq ORF: 657
• Locus ID: 12741
• Gene Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a critical component of endothelial tight junctions that control pericellular permeability. The knockout mice lacking this gene died within 10 h of birth and the blood-brain barrier in these mice against small molecules was selectively affected. This gene is expressed strongly in endothelium of normal lung and plays a regulation role during acrolein-induced acute lung injury. [provided by RefSeq, Aug 2010]