Cdk7 (NM_009874) Mouse Untagged Clone

CAT#: MC203456

Cdk7 (untagged) - Mouse cyclin-dependent kinase 7 (Cdk7), (10ug)


  "NM_009874" in other vectors (4)

Reconstitution Protocol

USD 210.00

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Size
    • 10 ug

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Specifications

Product Data
Type Mouse Untagged Clone
Tag Tag Free
Symbol Cdk7
Synonyms AI323415; AI528512; C230069N13; Cdkn7; Crk4
Vector PCMV6-Kan/Neo
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>BC068160
AAGTAGCTGTTGGGCAGCTTTCGGACGCTTTAAATTCCTGCGGGGTGGAGGGCTTAGCTTGGGTGCCCGG GTCTGGTTTCTCACTCGCATGGCTGTGGACGTGAAGTCTCGAGCGAAGCGCTATGAGAAACTGGACTTCC TCGGAGAGGGACAGTTTGCGACGGTCTATAAGGCCAGGGACAAGAACACCAACCAAATCGTCGCCATTAA GAAAATCAAACTTGGACACAGGTCAGAAGCTAAGGATGGAATAAATAGAACAGCCTTAAGGGAGATAAAG CTCTTACAGGAACTAAGTCATCCAAATATAATTGGTCTCCTTGATGCATTTGGACATAAGTCTAACATTA GCCTTGTCTTTGATTTTATGGAAACTGACCTCGAGGTTATTATAAAGGATAACAGCCTTGTGCTGACACC ATCCCACATTAAAGCCTACATGTTGATGACTCTTCAGGGCTTAGAATATTTACATCAGCATTGGATTCTA CACAGGGATCTGAAACCAAACAACTTGTTGTTAGATGAGAATGGAGTTCTGAAACTGGCAGATTTTGGCC TGGCCAAATCATTTGGGAGCCCCAATAGGGCTTACACACATCAAGTTGTGACCAGATGGTACCGGGCTCC TGAGTTATTGTTTGGAGCTAGGATGTATGGTGTGGGAGTAGACATGTGGGCTGTTGGTTGTATATTAGCA GAATTGCTTCTAAGGGTTCCATTTTTGCCTGGAGATTCAGATCTTGATCAGCTAACAAGGATATTTGAAA CTCTGGGTACACCAACTGAAGAGCAGTGGCCTGACATGTGTAGTCTTCCCGATTATGTGACATTTAAGAG TTTCCCTGGGGTCCCACTGCAGCACATCTTCATCGCGGCTGGGGACGACCTGCTGGAGCTCATCCAAGGC CTGTTCTTATTTAACCCGTGTACGCGGACCACAGCCTCACAGGCATTGAAGACCAAGTACTTCAGTAACC GCCCCGGGCCAACACCTGGATGCCAGCTCCCGCGACCAAACTGTCCGGTGGAGGCATTAAAGGAACCGGC GAATCCAACCGTGGCAACAAAGCGGAAAAGAGCAGAGGCCTTAGAACAAGGAATATTGCCCAAGAAGCTC ATTTTTTAGTTGCAGCGAACAATGGACAGTTTCACTGCTGAAATAAATGATCCAAAGGCAAATAATGGAA AAAATAGTGAATATTAAATGCTATAAGAGAGAACTTGTAAATATTCTACAGATGTAAAATATGTAAAACT ACGGGTTATTTTTATTAAATGTATTTTACAATAAAAAAAAAAAAAAAAAAAAAAAA
Restriction Sites AscI-NotI     
ACCN NM_009874
ORF Size 1041 bp
Insert Size 1041
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq BC068160, AAH68160
RefSeq Size 1316
RefSeq ORF 1041
Locus ID 12572
Gene Summary Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53; this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition. [UniProtKB/Swiss-Prot Function]

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