Psen2 (BC010403) Mouse Untagged Clone

CAT#: MC206272

Psen2 (untagged) - Mouse presenilin 2 (cDNA clone MGC:13863 IMAGE:4038761), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Psen2
• Synonyms: PS2, PS-2, ALG-3
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC010403
  CCACGCGTCCGCCCACGCGTCCGGGCGGAGCAGACCATGCTCGCATTCATGGCCTCTGACAGCGAGGAAG AGGTGTGTGATGAGCGGACGTCCTTGATGTCAGCCGAGAGCCCCACATCTCGCTCCTGCCAGGAAGGCAG GCCAGGCCCGGAGGATGGAGAGAGCACTGCCCAGTGGAGGACTCAGGAGAGCGAAGAAGACTGTGAAGAG GACCCGGACCGCTACGCATGCAGTGGGGCTCCTGGGCGACCGTCGGGCCTGGAGGAAGAGCTGACCCTCA AGTATGGGGCGAAGCATGTGATCATGCTATTCGTGCCTGTCACGCTGTGTATGATCGTGGTGGTGGCCAC TATCAAGTCTGTGCGTTTCTACACTGAGAAGAACGGGCAGCTCATCTACACGCCCTTCACGGAGGACACG CCCTCGGTGGGCCAGCGGCTCCTCAACTCCGTGCTTAACACCCTCATCATGATCAGCGTCATCGTAGTCA TGACCATCTTCCTCGTGGTACTCTACAAGTATCGATGCTACAAGTTCATCCATGGCTGGCTGATCATGTC CTCCCTGATGCTCCTCTTCTTGTTCACCTACATCTACCTCGGGGAAGTGCTCAAGACCTACAATGTGGCC ATGGACTATCCCACACTCTTCCTGGCTGTCTGGAACTTCGGGGCAGTGGGCATGGTGTGCATCCACTGGA AGGGGCCTCTGGTGCTGCAGCAGGCTTACCTTATTGTGATCAGCGCACTCATGGCCCTGGTGTTCATCAA GTACCTGCCGGAGTGGTCTGCCTGGGTCATCTTGGGTGCCATCTCTGTGTACGATCTCGTGGCCGTGCTG TGCCCCAAAGGGCCACTGAGGATGCTGGTGGAAACTGCCCAGGAGAGAAATGAGCCCATATTTCCTGCCC TGATATACTCATCTGCCATGGTGTGGACGGTGGGCATGGCAAAGCTGGACCCCTCCTCTCAAGGAGCGCT GCAGCTCCCCTATGACCCAGAGATGGAAGAAGACTCCTACGACAGTTTTGGAGAACCCTCATACCCTGAA GCCTTCGAAGCTCCCCTGCCTGGCTACCCAGGGGAGGAGCTGGAGGAGGAGGAGGAAAGGGGCGTGAAGC TCGGCCTGGGAGACTTCATCTTCTACAGCGTCCTGGTGGGCAAGGCTGCAGCCACTGGCAACGGAGACTG GAACACTACGCTGGCCTGTTTTATCGCCATCCTCATTGGCTTGTGTCTCACCCTCCTGCTGCTTGCTGTG TTCAAGAAGGCTCTGCCCGCCCTCCCCATCTCCATCACCTTTGGACTCATCTTCTACTTCTCCACAGACA ACCTGGTGCGCCCTTTCATGGACACTCTGGCCTCCCACCAGCTCTACATCTGACAGGAGCCAGGCGGAGG CTCCGAGAGCTATGGGGGCGTCACTGGATGCAGGTGTATAGTTTTACACTCTAGTGCCATATATTTTTTA AAGAAATTTTCTTTCCTTACAAAAGAAGAAGAAGAAAAAAAAAAAAAAAA
• Restriction Sites: EcoRI-NotI
• ACCN: BC010403
• ORF Size: 1347 bp
• Insert Size: 1347
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: BC010403, AAH10403
• RefSeq Size: 1520
• RefSeq ORF: 1347
• Locus ID: 19165
• Gene Summary: This gene encodes a member of the presenilin family. Presenilins are catalytic components of the multi-subunit gamma-secretase complex, which mediates critical cellular processes through cleavage of type I transmembrane proteins including Notch receptors and the amyloid precursor protein. The encoded protein contains eight transmembrane domains and is localized to the endoplasmic reticulum, where it may play a role in calcium homeostasis. Following assembly of the gamma-secretase complex, the encoded protein is cleaved into N- and C-terminal fragments and the activated complex is released from the endoplasmic reticulum. Inactivation of this gene results in impaired synaptic function in a mouse model for Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2011]