Aco1 (BC005454) Mouse Untagged Clone

CAT#: MC206784

Aco1 (untagged) - Mouse aconitase 1 (cDNA clone MGC:6247 IMAGE:3494686), (10ug)

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Reconstitution Protocol

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Size
    • 10 ug
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Specifications

Product Data
Type Mouse Untagged Clone
Tag Tag Free
Symbol Aco1
Synonyms Irp1
Vector PCMV6-Kan/Neo
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>BC005454
CACCCGCCTGTGTGCTCCGGGAACTGCACTGTGAGCGTTTTTCAGAGACACGTGACCATCAATAAGCATG AAGAACCCATTTGCACACCTTGCTGAGCCCTTGGACGCTGCCCAACCAGGAAAGAGGTTCTTCAACTTGA ATAAATTGGAGGACTCAAGATACGGACGCTTACCATTTTCTATCAGAGTTCTCCTGGAGGCAGCCGTTCG GAACTGTGATGAGTTTCTGGTGAAGAAAAATGACATCGAGAATATCCTGAATTGGAATGTCATGCAACAT AAGAACATAGAAGTGCCGTTTAAGCCAGCCCGAGTCATACTGCAAGACTTTACGGGTGTGCCTGCTGTGG TGGATTTTGCAGCAATGCGCGATGCTGTGAAGAAGTTGGGAGGGAATCCGGAGAAAATTAACCCTGTCTG CCCCGCTGACCTTGTAATTGATCATTCCATCCAGGTTGATTTCAACAGAAGGGCAGACAGTTTACAGAAG AATCAAGACCTGGAGTTTGAAAGAAATAAAGAACGATTTGAATTTCTAAAGTGGGGTTCCCAGGCCTTTT GCAACATGCGGATAATCCCTCCTGGCTCGGGAATCATTCACCAAGTGAACCTGGAGTATTTGGCAAGAGT AGTGTTTGATCAGGATGGATGCTACTACCCAGACAGCCTCGTGGGCACAGATTCACACACGACCATGATT GACGGCCTGGGAGTTCTTGGTTGGGGTGTGGGTGGTATTGAAGCAGAAGCTGTCATGCTGGGTCAGCCCA TCAGCATGGTGCTTCCCCAGGTGATTGGCTACAAGCTGATGGGGAAGCCTCACCCTCTGGTAACATCCAC GGACATCGTGCTCACCATTACCAAGCACCTCCGACAAGTGGGAGTTGTGGGCAAATTTGTGGAGTTTTTC GGGCCAGGAGTGGCTCAGCTGTCCATTGCTGACCGAGCTACGATTGCCAATATGTGCCCAGAGTATGGTG CGACAGCAGCCTTCTTCCCGGTTGATGAAGTTAGCATCGCGTACCTGCTGCAGACAGGCCGCGAGGAAGA CAAAGTCAAGCACATTCAGAAGTATCTTCAGGCTGTAGGCATGTTTCGAGATTTCAACGACACCTCTCAA GACCCAGACTTCACTCAGGTTGTGGAGTTAGATCTGAAAACAGTTGTGCCTTGCTGCAGTGGACCCAAAA GACCTCAGGACAAAGTCGCAGTGTCTGAGATGAAAAAGGACTTTGAAAGCTGCCTTGGAGCCAAGCAAGG ATTTAAAGGTTTCCAAGTTGCTTCAGACCGTCACAATGACCGCAAGACGTTCCTCTATAATAACAGTGAA TTCACTCTCGCTCACGGCTCTGTGGTAATCGCTGCCATCACTAGCTGCACAAACACCAGCAATCCATCCG TGATGTTAGGAGCAGGATTGTTAGCAAAGAAAGCTGTGGAGGCGGGGCTGAGTGTGAAGCCTTACATCAA AACCAGCCTGTCTCCTGGAAGTGGAGTGGTCACCTACTACCTTCGAGAGAGTGGAGTCATGCCTTACCTG TCCCAGTTAGGGTTTGATGTGGTGGGCTACGGCTGCATGACCTGCATCGGCAACAGTGGACCCCTTCCTG AACCTGTGGTCGAGGCGATCACCCAGGGAGACCTCGTAGCTGTTGGCGTTCTGTCTGGGAATAGGAATTT TGAAGGCCGAGTCCATCCTAACACACGAGCCAACTACTTAGCATCCCCCCCTCTGGTAATAGCATATGCG ATTGCAGGCACCGTCAGGATTGACTTCGAGAAAGAGCCTTTGGGAGTGAACGCACAGGGCCGGCAAGTGT TTCTGAAGGATATCTGGCCCACGCGAGATGAGATCCAGGCGGTGGAAAGGCAGTATGTCATCCCCGGGAT GTTTAAGGAGGTCTATCAGAAAATAGAGACTGTAAATAAAAGCTGGAATGCCTTAGCAGCCCCGTCAGAG AAGCTGTACGCGTGGAATCCCAAATCTACTTACATTAAGTCGCCGCCATTCTTTGAAAGCTTGACTTTAG ATCTCCAGCCACCCAAGTCCATAGTGGATGCCTATGTGCTACTGAATTTAGGAGATTCAGTAACAACGGA CCATATCTCTCCCGCCGGCAATATTGCAAGAAACAGCCCTGCGGCTCGCTACTTGACGAACAGAGGCCTA ACACCACGAGAGTTCAACTCCTATGGCTCCCGCCGGGGTAACGACGCCATCATGGCCCGGGGGACATTTG CCAACATTCGCTTGCTGAACAAGTTTCTGAACAAGCAGGCACCTCAGACTGTCCATCTCCCTTCAGGAGA AACCCTTGATGTATTCGACGCTGCTGAGCGGTACCAGCAGGCTGGACTTCCCCTGATTGTTCTGGCTGGG AAAGAATACGGTTCAGGCAGCTCCCGAGACTGGGCAGCCAAAGGCCCTTTCCTGCTGGGAATCAAAGCTG TCCTGGCAGAGAGCTATGAGCGCATTCACCGCAGCAACTTGGTTGGCATGGGGGTGATCCCCCTTGAGTA TCTCCCTGGTGAAACTGCAGACTCTCTGGGACTCACAGGTCGGGAAAGATACACTATCAACATCCCTGAA GACCTCAAGCCTCGCATGACGGTGCAGATCAAGCTGGACACTGGGAAGACCTTCCAGGCCGTGATGAGGT TCGACACTGATGTGGAGCTCACATACTTCCACAATGGAGGCATCCTGAACTACATGATCCGAAAGATGGC CCAGTAGGTGCTGGCCTCTCAGGAGACCCGCGCTTGGTGCTAGACCCAATGAGGAACCAGGCCCCCACTG GTGGAGGCCTGGCAGAGCAGCCACATCTACTTCTGATGAGGGTGCTGGCAGGATGAGCAAGTGGGCACTG CCATTCCTGGAGGCACAGAGCCAGGAGTCTCTAGTTTCGTGATTTGTTCATCTTTTTATCCCTTTCTGTA ATCTGGATTCTAGAATCACGGGAAGGTCCGTAGTACCAAAGAGAACTCGCTTCTCTTTAAAGTCACGGGC ATTGATTTTTTTCCCTCTGACTAATCTTGAGCTCAGCACTAGCCAGTATTCTCAGAAGTGGCTCCTACCC TTTCTGTTGTTCTGTGTTTGTCTCTGCTCGGTGACACCCTTCCCTGGAGAGCCCAGTCCTCCGTGTATTA CACCAGTGTTAACTGACATAGCATAAGACCTTCACACTTCAGATTCATAGCAGTGATGGGATCCCTTCCT TTGAAGTGAACAAGTCCTTGTAGATAGGTCACCCGTCAAAAGTGTTTGATTATCTACCTTTCAATCAACA TGAGATTGCCTCTTACCATTTTCAACGATTGTTGACAGGGGTCCTTTGTTTGAAAATAACTGGGGAGAGA TACGGGATTTCTAATTTGAATAAGATTAAATATATTTTCATGAAAAAAAAAAAAAAAAAA
Restriction Sites RsrII-NotI     
ACCN BC005454
ORF Size 2670 bp
Insert Size 2670
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq BC005454, AAH05454
RefSeq Size 3420
RefSeq ORF 2670
Locus ID 11428
Gene Summary This gene encodes a member of the aconitase/IPM isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Depending on iron levels in the cytosol, the encoded protein can function as either an aconitase enzyme or as an mRNA binding protein. When cellular iron levels are high, the encoded protein functions as an aconitase, an essential enzyme in the TCA cycle that catalyzes the conversion of citrate to isocitrate. When cellular iron levels are low, the encoded protein regulates iron uptake and utilization by binding to iron-responsive elements in the untranslated regions of mRNAs for genes involved in iron metabolism. Disruption of this gene is associated with pulmonary hypertension and polycythemia. [provided by RefSeq, Jan 2014]

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