Npc1 (NM_008720) Mouse Untagged Clone
CAT#: MC224120
Npc1 (untagged) - Mouse Niemann Pick type C1 (Npc1), (10ug)
"NM_008720" in other vectors (4)
Product Images
![](https://cdn.origene.com/img/defaults-img-expression-plasmids.jpg)
Specifications
Product Data | |
Type | Mouse Untagged Clone |
Tag | Tag Free |
Symbol | Npc1 |
Synonyms | A430089E03Rik; C85354; D18Ertd139e; D18Ertd723e; lcsd; nmf164; spm |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>MC224120 representing NM_008720
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGGTGCGCACCACCCGGCCCTCGGCCTGCTGCTGCTGCTGCTGTGCCCTGCGCAGGTGTTTTCGCAAT CCTGTGTTTGGTATGGAGAGTGTGGAATTGCGACTGGAGATAAGAGGTACAACTGTAAATATTCTGGCCC ACCAAAACCCCTCCCAAAGGACGGCTATGACTTAGTGCAGGAACTCTGTCCAGGACTCTTCTTTGACAAT GTCAGTCTCTGCTGTGACATTCAACAGCTTCAGACGCTGAAGAGTAACCTGCAGCTGCCCCTGCAGTTCC TGTCCAGGTGTCCGTCATGTTTTTATAACCTAATGACCCTGTTTTGTGAGCTAACATGTAGCCCACACCA GAGTCAGTTTCTGAATGTGACAGCAACTGAGGATTATTTTGATCCTAAGACACAGGAGAATAAAACAAAT GTAAAGGAATTAGAGTACTTTGTCGGACAGAGCTTCGCGAATGCGATGTACAATGCCTGCCGTGATGTGG AGGCGCCTTCCAGTAACGAGAAGGCCTTAGGACTCTTGTGTGGGAGGGATGCCCGTGCCTGCAATGCCAC CAACTGGATTGAGTACATGTTCAATAAAGACAACGGACAAGCGCCATTTACCATCATTCCTGTGTTTTCA GATCTTTCAATCCTTGGGATGGAGCCCATGAGAAATGCCACCAAAGGCTGCAATGAGTCTGTAGATGAGG TCACGGGGCCATGTAGCTGCCAGGACTGCTCCATCGTCTGCGGCCCCAAGCCCCAGCCCCCACCCCCTCC TATGCCCTGGAGGATCTGGGGCTTGGATGCCATGTATGTCATCATGTGGGTCACCTACGTGGCATTTCTG TTTGTGTTTTTTGGAGCACTGTTGGCAGTGTGGTGCCACAGAAGGCGGTACTTTGTGTCTGAGTACACTC CCATTGACAGTAACATCGCCTTTTCTGTGAATAGCAGTGACAAAGGGGAAGCCTCATGCTGTGACCCACT TGGTGCAGCATTTGATGACTGTCTGAGGCGCATGTTCACAAAGTGGGGGGCTTTCTGTGTCCGAAATCCC ACCTGCATCATTTTCTTCTCATTGGCCTTCATCACTGTGTGCTCTTCTGGCCTGGTATTTGTCCAGGTCA CCACCAATCCTGTAGAGCTCTGGTCAGCCCCTCACAGTCAGGCCCGCTTGGAAAAGGAGTACTTTGACAA GCACTTTGGGCCTTTCTTTCGCACGGAGCAGCTTATCATCCAGGCCCCCAACACCAGTGTTCATATCTAC GAACCGTACCCCGCAGGAGCCGATGTGCCCTTCGGGCCTCCATTGAACAAAGAGATTCTGCACCAGGTTC TGGACTTACAGATCGCCATTGAAAGCATCACCGCATCTTACAACAATGAAACCGTGACACTGCAGGACAT CTGTGTGGCCCCCCTCTCTCCATACAACAAGAACTGCACCATTATGAGTGTGTTAAATTACTTCCAGAAC AGCCATGCGGTGCTGGACAGCCAAGTAGGCGACGACTTCTATATCTACGCTGATTACCACACACACTTTC TGTACTGTGTACGGGCTCCCGCCTCCTTGAATGATACGAGTTTGCTCCACGGTCCTTGCCTGGGTACATT TGGAGGACCGGTGTTCCCGTGGCTTGTGTTGGGTGGCTATGATGATCAGAACTACAACAATGCCACCGCG CTTGTGATCACCTTCCCCGTGAATAATTACTACAATGACACAGAGAGGCTCCAGAGGGCCTGGGCCTGGG AGAAAGAGTTTATTAGTTTTGTGAAAAACTACAAGAATCCAAATCTGACCATTTCTTTCACTGCTGAGCG AAGCATCGAAGATGAGCTCAATCGGGAAAGTAACAGTGACGTGTTCACCGTCATCATCAGCTACGTCGTG ATGTTTCTGTACATTTCCCTCGCCCTGGGTCACATCCAGAGCTGCAGCAGGCTCCTGGTGGATTCTAAGA TCTCGCTGGGCATTGCGGGGATCCTGATCGTGCTAAGCTCGGTGGCCTGCTCTCTGGGCATCTTCAGCTA CATGGGGATGCCGCTGACCCTCATCGTCATTGAGGTCATCCCATTCCTGGTGCTGGCTGTCGGGGTGGAC AACATCTTCATTCTAGTGCAGACCTACCAGAGAGATGAGCGTCTTCAGGAGGAAACGCTGGATCAGCAGC TGGGCAGGATCCTTGGAGAAGTGGCCCCGACCATGTTCCTTTCATCCTTTTCTGAGACCTCAGCATTTTT CTTTGGGGCGCTGTCCTCGATGCCAGCTGTGCACACCTTCTCTCTGTTTGCGGGAATGGCCGTCCTCATT GACTTCCTCCTTCAGATTACCTGCTTTGTGAGCCTGTTGGGGTTAGATATTAAGAGGCAAGAGAAAAACC ATCTGGACATCCTGTGCTGTGTCAGAGGCGCTGACGACGGACAAGGTAGCCACGCCTCCGAAAGCTACCT GTTTCGCTTCTTCAAAAACTACTTTGCCCCCCTTCTGCTGAAGGACTGGCTGAGGCCAATTGTGGTAGCG GTGTTTGTGGGCGTTCTGTCATTCAGTGTTGCGGTGGTGAACAAAGTAGACATCGGGTTGGATCAGTCTC TCTCAATGCCAAACGATTCGTATGTGATTGACTATTTCAAATCACTCGCTCAGTACCTGCACTCGGGCCC ACCCGTGTACTTTGTCCTGGAGGAAGGCTATAACTACAGTTCACGCAAAGGGCAGAACATGGTGTGCGGC GGCATGGGCTGTGACAATGACTCCCTGGTGCAGCAGATATTTAACGCAGCTGAGCTGGACACCTACACCC GAGTAGGCTTCGCCCCCTCGTCCTGGATCGATGACTACTTTGACTGGGTCTCGCCACAGTCGTCCTGCTG CAGACTCTACAACGTCACTCACCAGTTCTGCAATGCTTCTGTGATGGACCCAACCTGTGTCCGCTGCAGA CCTCTGACTCCAGAGGGTAAACAGAGGCCTCAGGGGAAAGAATTCATGAAATTCCTGCCCATGTTCCTTT CTGATAACCCCAACCCCAAGTGCGGCAAAGGGGGACATGCTGCTTACGGTTCAGCTGTTAACATTGTGGG AGATGACACTTACATTGGGGCCACTTACTTCATGACCTACCACACCATACTTAAGACCTCCGCTGACTAT ACTGATGCCATGAAGAAAGCTCGGCTAATAGCCAGTAACATCACGGAAACCATGCGTTCTAAGGGGAGTG ACTACCGCGTATTCCCTTACAGTGTGTTCTACGTCTTCTATGAACAGTACCTGACCATTATTGATGACAC CATCTTTAACCTCAGTGTGTCTCTGGGCTCCATATTTCTGGTGACCTTGGTGGTTCTGGGCTGTGAGCTG TGGTCTGCGGTCATCATGTGTATCACCATAGCCATGATCCTGGTCAACATGTTCGGTGTCATGTGGCTGT GGGGCATCAGTCTGAATGCGGTCTCCTTGGTCAACTTGGTGATGAGCTGCGGCATTTCTGTGGAGTTCTG CAGCCATATAACGAGAGCATTCACCATGAGTACCAAAGGAAGCCGAGTGAGCCGGGCGGAAGAGGCACTG GCCCACATGGGTAGTTCTGTATTCAGTGGAATCACACTTACGAAATTTGGAGGGATCGTGGTGTTAGCCT TTGCCAAATCTCAAATTTTTGAGATATTTTACTTCAGGATGTACTTAGCCATGGTCTTACTCGGAGCCAC TCATGGACTAATATTTCTTCCCGTCTTACTCAGTTACATAGGGCCGTCGGTGAATAAAGCTAAAAGACAC ACCACTTACGAGCGCTACAGAGGGACAGAGAGAGAACGGCTCCTCAATTTTTAG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
Restriction Sites | SgfI-MluI |
ACCN | NM_008720 |
ORF Size | 3834 bp |
Insert Size | 3834 |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
Reference Data | |
RefSeq | NM_008720.2, NP_032746.2 |
RefSeq Size | 5209 |
RefSeq ORF | 3834 |
Locus ID | 18145 |
Gene Summary | Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals. [UniProtKB/Swiss-Prot Function] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
MR211885 | Npc1 (Myc-DDK-tagged) - Mouse Niemann Pick type C1 (Npc1) |
USD 1,340.00 |
|
MG211885 | Npc1 (GFP-tagged) - Mouse Niemann Pick type C1 (Npc1) |
USD 1,470.00 |
|
MR211885L3 | Lenti ORF clone of Npc1 (Myc-DDK-tagged) - Mouse Niemann Pick type C1 (Npc1) |
USD 1,540.00 |
|
MR211885L4 | Lenti ORF clone of Npc1 (mGFP-tagged) - Mouse Niemann Pick type C1 (Npc1) |
USD 1,908.00 |
{0} Product Review(s)
Be the first one to submit a review