Gfra2 (NM_001302095) Mouse Untagged Clone

CAT#: MC227079

Gfra2 (untagged) - Mouse glial cell line derived neurotrophic factor family receptor alpha 2 (Gfra2), transcript variant 3

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Gfra2
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC227079 representing NM_001302095
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGATCTTGGCAAACGCCTTCTGCCTCTTCTTCTTTTTAGGGACAGGGGCAGACCCGGTGGTCAGTGCCA
  AGAGCAACCACTGCCTGGATGCCGCCAAGGCCTGCAACCTGAACGACAACTGCAAGAAGCTCCGCTCCTC
  CTACATCTCCATCTGCAACCGCGAGATCTCTCCCACCGAACGCTGCAACCGCCGCAAGTGCCACAAGGCC
  CTGCGCCAGTTCTTCGACCGTGTGCCCAGCGAGTATACCTACCGCATGCTCTTCTGCTCCTGTCAGGACC
  AGGCATGCGCCGAGCGTCGCCGGCAAACCATCCTGCCCAGCTGTTCCTATGAGGACAAAGAGAAGCCCAA
  TTGCTTGGACCTGCGCAGCCTGTGTCGTACAGACCACTTGTGCCGGTCCCGCCTGGCAGACTTCCACGCC
  AACTGTCGAGCCTCCTACCGGACAATCACCAGCTGCCCTGCGGACAACTACCAGGCATGTCTGGGCTCCT
  ATGCTGGCATGATTGGGTTTGATATGACACCGAACTATGTGGACTCCAACCCCACGGGCATCGTGGTGTC
  TCCCTGGTGCAATTGTCGTGGCAGTGGGAACATGGAAGAAGAGTGTGAGAAGTTCCTCAAGGACTTCACA
  GAAAACCCATGCCTCCGGAATGCCATTCAAGCCTTTGGCAATGGCACAGATGTGAACATGTCTCCCAAAG
  GCCCCACATTTTCAGCTACCCAGGCCCCTCGGGTAGAGAAAACTCCTTCACTGCCAGATGACCTCAGTGA
  TAGCACCAGCCTGGGGACCAGTGTCATCACCACCTGCACATCTATCCAGGAGCAAGGGCTGAAGGCCAAC
  AACTCCAAAGAGTTAAGCATGTGTTTCACAGAGCTCACGACAAATATCAGCCCAGGGAGTAAAAAGGTGA
  TCAAACTTTACTCAGGCTCCTGCAGAGCCAGACTGTCGACTGCCTTGACTGCCCTCCCACTCCTGATGGT
  GACCTTGGCCCAGTAG
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_001302095
• ORF Size: 996 bp
• Insert Size: 996
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This clone expresses the complete ORF with c-terminal tags of Myc-DDK.

Reference Data

• RefSeq: NM_001302095.1, NP_001289024.1
• RefSeq Size: 3088
• RefSeq ORF: 996
• Locus ID: 14586
• Gene Summary: The protein encoded by this gene is part of the receptor complex that transduces glial cell-derived neurotrophic factor and neurturin signals by mediating autophosphorylation and activation of the RET receptor. Mice lacking this protein are viable and fertile but display growth retardation attributed to impaired salivary and pancreatic secretion and innervation deficits in the intestinal tract. In addition, knockout mice display neural defects including a failure to initiate outgrowth of dorsal ganglion root neurons, demonstrating a requirement in neuronal differentiation of these cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
  Transcript Variant: This variant (3) lacks two consecutive in-frame exons in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 3) compared to isoform 1. This isoform (3) may undergo proteolytic processing similar to isoform 1.