Gfra2 (NM_001302094) Mouse Untagged Clone

CAT#: MC227268

Gfra2 (untagged) - Mouse glial cell line derived neurotrophic factor family receptor alpha 2 (Gfra2), transcript variant 2

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Gfra2
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC227268 representing NM_001302094
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGATCTTGGCAAACGCCTTCTGCCTCTTCTTCTTTTTAGGTGAGGAGTTCTACGAAGCTTCGCCCTATG
  AGCCTGTGACCTCCCGCCTCTCGGACATCTTCAGGCTCGCTTCAATCTTCTCAGGGACAGGGGCAGACCC
  GGTGGTCAGTGCCAAGAGCAACCACTGCCTGGATGCCGCCAAGGCCTGCAACCTGAACGACAACTGCAAG
  AAGCTCCGCTCCTCCTACATCTCCATCTGCAACCGCGAGATCTCTCCCACCGAACGCTGCAACCGCCGCA
  AGTGCCACAAGGCCCTGCGCCAGTTCTTCGACCGTGTGCCCAGCGAGTATACCTACCGCATGCTCTTCTG
  CTCCTGTCAGGACCAGGCATGCGCCGAGCGTCGCCGGCAAACCATCCTGCCCAGCTGTTCCTATGAGGAC
  AAAGAGAAGCCCAATTGCTTGGACCTGCGCAGCCTGTGTCGTACAGACCACTTGTGCCGGTCCCGCCTGG
  CAGACTTCCACGCCAACTGTCGAGCCTCCTACCGGACAATCACCAGCTGCCCTGCGGACAACTACCAGGC
  ATGTCTGGGCTCCTATGCTGGCATGATTGGGTTTGATATGACACCGAACTATGTGGACTCCAACCCCACG
  GGCATCGTGGTGTCTCCCTGGTGCAATTGTCGTGGCAGTGGGAACATGGAAGAAGAGTGTGAGAAGTTCC
  TCAAGGACTTCACAGAAAACCCATGCCTCCGGAATGCCATTCAAGCCTTTGGCAATGGCACAGATGTGAA
  CATGTCTCCCAAAGGCCCCACATTTTCAGCTACCCAGGCCCCTCGGGTAGAGAAAACTCCTTCACTGCCA
  GATGACCTCAGTGATAGCACCAGCCTGGGGACCAGTGTCATCACCACCTGCACATCTATCCAGGAGCAAG
  GGCTGAAGGCCAACAACTCCAAAGAGTTAAGCATGTGTTTCACAGAGCTCACGACAAATATCAGCCCAGG
  GAGTAAAAAGGTGATCAAACTTTACTCAGGCTCCTGCAGAGCCAGACTGTCGACTGCCTTGACTGCCCTC
  CCACTCCTGATGGTGACCTTGGCCCAGTAG
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_001302094
• ORF Size: 1080 bp
• Insert Size: 1080
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This clone expresses the complete ORF with c-terminal tags of Myc-DDK.

Reference Data

• RefSeq: NM_001302094.1, NP_001289023.1
• RefSeq Size: 3172
• RefSeq ORF: 1080
• Locus ID: 14586
• Gene Summary: The protein encoded by this gene is part of the receptor complex that transduces glial cell-derived neurotrophic factor and neurturin signals by mediating autophosphorylation and activation of the RET receptor. Mice lacking this protein are viable and fertile but display growth retardation attributed to impaired salivary and pancreatic secretion and innervation deficits in the intestinal tract. In addition, knockout mice display neural defects including a failure to initiate outgrowth of dorsal ganglion root neurons, demonstrating a requirement in neuronal differentiation of these cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
  Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region. This results in a shorter protein (isoform 2) compared to isoform 1.