KEAP1 (NM_012289) Human Tagged ORF Clone

CAT#: RC202513L2

Lenti ORF clone of Human kelch-like ECH-associated protein 1 (KEAP1), transcript variant 2, mGFP tagged

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: mGFP
• Symbol: KEAP1
• Synonyms: INrf2; KLHL19
• Vector: pLenti-C-mGFP
• E. coli Selection: Chloramphenicol (34 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC202513).
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene
• ACCN: NM_012289
• ORF Size: 1872 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_012289.3, NP_036421.2
• RefSeq Size: 2577
• RefSeq ORF: 1875
• Locus ID: 9817
• Domains: BTB, Kelch
• Protein Families: Transcription Factors
• Protein Pathways: Ubiquitin mediated proteolysis
• MW: 69.7 kDa
• Gene Summary: This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]