ARHGEF6 (NM_004840) Human Tagged ORF Clone

CAT#: RC208074L3

Lenti-ORF clone of ARHGEF6 (Myc-DDK-tagged)-Human Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 (ARHGEF6)

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: ARHGEF6
• Synonyms: alpha-PIX; alphaPIX; Cool-2; COOL2; MRX46; PIXA
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• E. coli Selection: Chloramphenicol (34 ug/mL)
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC208074).
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene
• ACCN: NM_004840
• ORF Size: 2328 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_004840.2, NP_004831.1
• RefSeq Size: 5282
• RefSeq ORF: 2331
• Locus ID: 9459
• Domains: RhoGEF, SH3, CH, PH
• Protein Families: Druggable Genome
• Protein Pathways: Pancreatic cancer, Regulation of actin cytoskeleton
• MW: 87.3 kDa
• Gene Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability. [provided by RefSeq, Jul 2008]