KCNH8 (NM_144633) Human Tagged ORF Clone

CAT#: RC212154

KCNH8 (Myc-DDK-tagged)-Human potassium voltage-gated channel, subfamily H (eag-related), member 8 (KCNH8)

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: KCNH8
• Synonyms: ELK; ELK1; elk3; Kv12.1
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RC212154 representing NM_144633
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGCCGGTTATGAAAGGATTACTGGCGCCGCAAAACACCTTCCTGGACACCATCGCCACCCGTTTTGACG
  GAACACATAGCAACTTCATCCTTGCCAATGCCCAGGTGGCTAAGGGTTTCCCCATAGTCTACTGTTCCGA
  TGGCTTCTGCGAGCTTGCTGGATTTGCCCGAACTGAAGTCATGCAGAAGAGTTGTAGCTGCAAGTTCTTA
  TTTGGGGTTGAAACCAATGAGCAACTGATGCTTCAAATAGAAAAGTCACTGGAGGAGAAAACAGAATTCA
  AAGGAGAAATTATGTTCTACAAGAAAAACGGGTCTCCATTTTGGTGCCTACTGGATATTGTTCCCATAAA
  GAATGAAAAAGGAGATGTAGTACTTTTTCTGGCCTCGTTCAAAGATATAACAGATACAAAAGTGAAGATT
  ACTCCAGAAGATAAAAAAGAAGACAAAGTCAAAGGAAGATCAAGAGCAGGGACCCACTTTGACTCAGCCC
  GGAGACGGAGTCGAGCAGTCCTTTATCACATCTCTGGGCACCTGCAAAGAAGAGAAAAGAACAAATTGAA
  AATAAATAACAATGTTTTTGTAGATAAACCAGCATTTCCGGAGTATAAAGTTTCTGATGCAAAAAAGTCC
  AAATTCATACTTCTGCATTTTAGCACTTTTAAAGCTGGCTGGGACTGGCTTATTTTGTTGGCAACGTTTT
  ATGTTGCTGTGACTGTACCTTACAACGTTTGCTTTATTGGCAATGACGACCTGTCCACAACTCGGAGCAC
  AACCGTCAGTGACATTGCAGTGGAGATTCTTTTTATTATAGATATTATTTTAAATTTCCGAACAACTTAT
  GTCAGCAAGTCTGGCCAAGTTATCTTTGAAGCAAGATCAATTTGCATCCACTATGTCACAACCTGGTTCA
  TCATTGATTTAATCGCTGCCCTGCCTTTTGATCTTCTGTATGCTTTCAACGTCACAGTGGTGTCTCTCGT
  GCATCTTCTAAAGACAGTGCGCCTCTTGCGTCTTTTGCGTCTGCTGCAGAAGTTAGACCGCTATTCCCAA
  CACAGTACTATCGTCCTGACTCTGCTCATGTCCATGTTTGCACTCCTTGCACACTGGATGGCGTGTATCT
  GGTACGTCATTGGAAAAATGGAGAGGGAAGACAACAGCCTTCTGAAGTGGGAAGTTGGTTGGCTTCATGA
  GTTGGGAAAGAGACTGGAATCTCCATACTATGGCAACAATACCTTGGGGGGCCCGTCGATCCGAAGTGCC
  TATATTGCCGCTCTGTACTTCACGCTGAGCAGCCTCACCAGCGTGGGTTTTGGGAACGTCTCTGCTAATA
  CAGATGCAGAAAAGATCTTCTCCATCTGCACCATGCTGATTGGTGCCTTGATGCACGCCTTGGTGTTTGG
  AAACGTGACAGCAATCATACAGAGGATGTACTCCAGATGGTCCCTCTATCACACTAGAACTAAGGATCTG
  AAAGATTTCATCCGTGTCCATCACTTGCCCCAACAACTCAAGCAGAGGATGCTCGAATATTTTCAAACAA
  CCTGGTCAGTCAACAATGGAATAGATTCAAATGAGCTTTTGAAAGACTTTCCAGATGAACTGCGTTCTGA
  CATCACTATGCACTTGAACAAGGAGATCTTACAGTTGTCCCTTTTTGAATGTGCCAGCCGGGGCTGCCTC
  AGGTCTCTGTCTCTACACATCAAAACCTCTTTCTGTGCTCCGGGGGAGTATCTGCTGCGTCAAGGGGATG
  CTTTGCAGGCCATCTACTTTGTATGCTCGGGCTCCATGGAAGTTCTTAAAGACAGCATGGTGCTGGCTAT
  TCTTGGGAAAGGGGATTTAATTGGAGCAAATCTATCAATTAAGGACCAAGTGATCAAGACCAATGCAGAT
  GTAAAGGCTTTAACCTACTGTGATCTCCAGTGTATCATCCTCAAAGGACTCTTTGAAGTGCTAGACCTTT
  ACCCAGAATATGCTCACAAATTCGTGGAAGACATTCAGCATGACCTCACATACAACCTCCGAGAAGGTCA
  TGAGAGTGATGTGATATCAAGACTATCAAACAAATCTATGGTCTCACAGTCAGAGCCCAAGGGAAATGGC
  AACATCAACAAGCGACTCCCATCCATTGTGGAAGATGAGGAAGAGGAGGAGGAGGGGGAGGAAGAGGAGG
  CAGTCTCCCTCTCTCCCATCTGCACAAGGGGATCTTCTTCGCGCAACAAGAAGGTTGGAAGCAATAAAGC
  CTACCTGGGCTTAAGCTTAAAGCAACTGGCCTCGGGAACGGTGCCCTTTCACTCGCCTATCAGAGTCTCC
  AGGTCAAATTCCCCCAAAACCAAGCAGGAAATTGACCCCCCCAACCATAATAAAAGGAAAGAGAAGAACT
  TGAAATTGCAACTTTCAACTTTGAATAATGCTGGACCCCCAGACCTCAGTCCAAGGATTGTTGATGGAAT
  TGAAGATGGAAACAGCAGTGAAGAAAGTCAGACTTTTGATTTTGGCTCTGAACGAATCAGATCAGAGCCC
  AGAATTTCTCCTCCTCTTGGAGATCCAGAGATTGGAGCTGCTGTTCTCTTCATCAAAGCAGAGGAGACCA
  AGCAGCAGATAAACAAACTCAACAGTGAGGTAACAACATTGACTCAGGAAGTTTCTCAGTTGGGTAAAGA
  CATGAGAAATGTGATCCAGCTTCTGGAAAACGTTCTGTCACCTCAGCAGCCATCACGGTTTTGCTCTTTG
  CACAGCACCTCTGTGTGTCCCTCCAGGGAGAGCTTACAGACCAGAACGAGCTGGAGTGCACACCAGCCTT
  GCCTACACTTGCAAACAGGCGGGGCTGCTTATACCCAAGCACAACTTTGTAGCAGTAATATCACCTCAGA
  CATTTGGAGTGTGGATCCCTCCTCTGTGGGGAGCAGCCCCCAACGAACTGGAGCTCATGAGCAAAATCCT
  GCAGACAGTGAACTTTATCATTCTCCAAGCCTTGATTATTCACCTTCCCACTACCAGGTTGTCCAAGAAG
  GTCATTTGCAATTTTTAAGGTGCATCTCTCCACATTCAGATTCTACGTTGACGCCTCTGCAGTCCATTTC
  AGCAACTCTCTCATCTTCTGTCTGCTCCTCTTCGGAAACATCTTTGCACCTAGTTCTCCCAAGCAGATCA
  GAGGAGGGCAGCTTCAGTCAGGGAACTGTGAGTTCCTTCAGTCTGGAAAACTTACCAGGATCTTGGAACC
  AGGAAGGAATGGCATCAGCTTCTACAAAACCTTTGGAGAACCTTCCACTGGAAGTTGTCACAAGCACAGC
  AGAAGTGAAAGATAACAAAGCCATAAATGTA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >RC212154 representing NM_144633
  Red=Cloning site Green=Tags(s)
  
  MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKSCSCKFL
  FGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEKGDVVLFLASFKDITDTKVKI
  TPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQRREKNKLKINNNVFVDKPAFPEYKVSDAKKS
  KFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRSTTVSDIAVEILFIIDIILNFRTTY
  VSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQ
  HSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSA
  YIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDL
  KDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQLSLFECASRGCL
  RSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNAD
  VKALTYCDLQCIILKGLFEVLDLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNG
  NINKRLPSIVEDEEEEEEGEEEEAVSLSPICTRGSSSRNKKVGSNKAYLGLSLKQLASGTVPFHSPIRVS
  RSNSPKTKQEIDPPNHNKRKEKNLKLQLSTLNNAGPPDLSPRIVDGIEDGNSSEESQTFDFGSERIRSEP
  RISPPLGDPEIGAAVLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRNVIQLLENVLSPQQPSRFCSL
  HSTSVCPSRESLQTRTSWSAHQPCLHLQTGGAAYTQAQLCSSNITSDIWSVDPSSVGSSPQRTGAHEQNP
  ADSELYHSPSLDYSPSHYQVVQEGHLQFLRCISPHSDSTLTPLQSISATLSSSVCSSSETSLHLVLPSRS
  EEGSFSQGTVSSFSLENLPGSWNQEGMASASTKPLENLPLEVVTSTAEVKDNKAINV
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_144633
• ORF Size: 3321 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_144633.1, NM_144633.2, NP_653234.2
• RefSeq Size: 5106
• RefSeq ORF: 3324
• Locus ID: 131096
• Domains: cNMP, PAC, ion_trans
• Protein Families: Druggable Genome, Ion Channels: Potassium, Transmembrane
• MW: 123.6 kDa
• Gene Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. [provided by RefSeq, Jul 2008]