Topoisomerase II beta (TOP2B) (NM_001068) Human Tagged ORF Clone
CAT#: RC224802
- TrueORF®
TOP2B (Myc-DDK-tagged)-Human topoisomerase (DNA) II beta 180kDa (TOP2B)
"NM_001068" in other vectors (4)
Product Images
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | Myc-DDK |
Symbol | TOP2B |
Synonyms | top2beta; TOPIIB |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>RC224802 representing NM_001068
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCCAAGTCGGGTGGCTGCGGCGCGGGAGCCGGCGTGGGCGGCGGCAACGGGGCACTGACCTGGGTGA ACAATGCTGCAAAAAAAGAAGAGTCAGAAACTGCCAACAAAAATGATTCTTCAAAGAAGTTGTCTGTTGA GAGAGTGTATCAGAAGAAGACACAACTTGAACACATTCTTCTTCGTCCTGATACATATATTGGGTCAGTG GAGCCATTGACGCAGTTCATGTGGGTGTATGATGAAGATGTAGGAATGAATTGCAGGGAGGTTACCTTTG TGCCAGGTTTATACAAGATCTTTGATGAAATTTTGGTTAATGCTGCTGACAATAAACAGAGGGATAAGAA CATGACTTGTATTAAAGTTTCTATTGATCCTGAATCTAACATTATAAGCATTTGGAATAATGGGAAAGGC ATTCCAGTAGTAGAACACAAGGTAGAGAAAGTTTATGTTCCTGCTTTAATTTTTGGACAGCTTTTAACAT CCAGTAACTATGATGATGATGAGAAAAAAGTTACAGGTGGTCGTAATGGTTATGGTGCAAAACTTTGTAA TATTTTCAGTACAAAGTTTACAGTAGAAACAGCTTGCAAAGAATACAAACACAGTTTTAAGCAGACATGG ATGAATAATATGATGAAGACTTCTGAAGCCAAAATTAAACATTTTGATGGTGAAGATTACACATGCATAA CATTCCAACCAGATCTGTCCAAATTTAAGATGGAAAAACTTGACAAGGATATTGTGGCCCTCATGACTAG AAGGGCATATGATTTGGCTGGTTCGTGTAGAGGGGTCAAGGTCATGTTTAATGGAAAGAAATTGCCTGTA AATGGATTTCGCAGTTATGTAGATCTTTATGTGAAAGACAAATTGGATGAAACTGGGGTGGCCCTGAAAG TTATTCATGAGCTTGCAAATGAAAGATGGGATGTTTGTCTCACATTGAGTGAAAAAGGATTCCAGCAAAT CAGCTTTGTAAATAGTATTGCAACTACAAAAGGTGGACGGCACGTGGATTATGTGGTAGATCAAGTTGTT GGTAAACTGATTGAAGTAGTTAAGAAAAAGAACAAAGCTGGTGTATCAGTGAAACCATTTCAAGTAAAAA ACCATATATGGGTTTTTATTAATTGCCTTATTGAAAATCCAACTTTTGATTCTCAGACTAAGGAAAACAT GACTCTGCAGCCCAAAAGTTTTGGGTCTAAATGCCAGCTGTCAGAAAAATTTTTTAAAGCAGCCTCTAAT TGTGGCATTGTAGAAAGTATCCTGAACTGGGTGAAATTTAAGGCTCAGACTCAGCTGAATAAGAAGTGTT CATCAGTAAAATACAGTAAAATCAAAGGTATTCCCAAACTGGATGATGCTAATGATGCTGGTGGTAAACA TTCCCTGGAGTGTACACTGATATTAACAGAGGGAGACTCTGCCAAATCACTGGCTGTGTCTGGATTAGGT GTGATTGGACGAGACAGATACGGAGTTTTTCCACTCAGGGGCAAAATTCTTAATGTACGGGAAGCTTCTC ATAAACAGATCATGGAAAATGCTGAAATAAATAATATTATTAAAATAGTTGGTCTACAATATAAGAAAAG TTACGATGATGCAGAATCTCTGAAAACCTTACGCTATGGAAAGATTATGATTATGACCGATCAGGATCAA GATGGTTCTCACATAAAAGGCCTGCTTATTAATTTCATCCATCACAATTGGCCATCACTTTTGAAGCATG GTTTTCTTGAAGAGTTCATTACTCCTATTGTAAAGGCAAGCAAAAATAAGCAGGAACTTTCCTTCTACAG TATTCCTGAATTTGACGAATGGAAAAAACATATAGAAAACCAGAAAGCCTGGAAAATAAAGTACTATAAA GGATTGGGTACTAGTACAGCTAAAGAAGCAAAGGAATATTTTGCTGATATGGAAAGGCATCGCATCTTGT TTAGATATGCTGGTCCTGAAGATGATGCTGCCATTACCTTGGCATTTAGTAAGAAGAAGATTGATGACAG AAAAGAATGGTTAACAAATTTTATGGAAGACCGGAGACAGCGTAGGCTACATGGCTTACCAGAGCAATTT TTATATGGTACTGCAACAAAGCATTTGACTTATAATGATTTCATCAACAAGGAATTGATTCTCTTCTCAA ACTCAGACAATGAAAGATCTATACCATCTCTTGTTGATGGCTTTAAACCTGGCCAGCGGAAAGTTTTATT TACCTGTTTCAAGAGGAATGATAAACGTGAAGTAAAAGTTGCCCAGTTGGCTGGCTCTGTTGCTGAGATG TCGGCTTATCATCATGGAGAACAAGCATTGATGATGACTATTGTGAATTTGGCTCAGAACTTTGTGGGAA GTAACAACATTAACTTGCTTCAGCCTATTGGTCAGTTTGGAACTCGGCTTCATGGTGGCAAAGATGCTGC AAGCCCTCGTTATATTTTCACAATGTTAAGCACTTTAGCAAGGCTACTTTTTCCTGCTGTGGATGACAAC CTCCTTAAGTTCCTTTATGATGATAATCAACGTGTAGAGCCTGAGTGGTATATTCCTATAATTCCCATGG TTTTAATAAATGGTGCTGAGGGCATTGGTACTGGATGGGCTTGTAAACTACCCAACTATGATGCTAGGGA AATTGTGAACAATGTCAGACGAATGCTAGATGGCCTGGATCCTCATCCCATGCTTCCAAACTACAAAAAC TTTAAAGGCACGATTCAAGAACTTGGTCAAAACCAGTATGCAGTCAGTGGTGAAATATTTGTAGTGGACA GAAACACAGTAGAAATTACAGAGCTTCCAGTTAGAACTTGGACACAGGTATATAAAGAACAGGTTTTAGA ACCTATGCTAAATGGAACAGATAAAACACCAGCATTAATTTCTGATTATAAAGAATATCATACTGACACA ACTGTGAAATTTGTGGTGAAAATGACTGAAGAGAAACTAGCACAAGCAGAAGCTGCTGGACTGCATAAAG TTTTTAAACTTCAAACTACTCTTACTTGTAATTCCATGGTACTTTTTGATCATATGGGATGTCTGAAGAA ATATGAAACTGTGCAAGACATTCTGAAAGAATTCTTTGATTTACGATTAAGTTATTACGGTTTACGTAAG GAGTGGCTTGTGGGAATGTTGGGAGCAGAATCTACAAAGCTTAACAATCAAGCCCGTTTCATTTTAGAGA AGATACAAGGGAAAATTACTATAGAGAATAGGTCAAAGAAAGATTTGATTCAAATGTTAGTCCAGAGAGG TTATGAATCTGACCCAGTGAAAGCCTGGAAAGAAGCACAAGAAAAGGCAGCAGAAGAGGATGAAACACAA AACCAGCATGATGATAGTTCCTCCGATTCAGGAACTCCTTCAGGCCCAGATTTTAATTATATTTTAAATA TGTCTCTGTGGTCTCTTACTAAAGAAAAAGTTGAAGAACTGATTAAACAGAGAGATGCAAAAGGGCGAGA GGTCAATGATCTTAAAAGAAAATCTCCTTCAGATCTTTGGAAAGAGGATTTAGCGGCATTTGTTGAAGAA CTGGATAAAGTGGAATCTCAAGAACGAGAAGATGTTCTGGCTGGAATGTCTGGAAAAGCAATTAAAGGTA AAGTTGGCAAACCTAAGGTGAAGAAACTCCAGTTGGAAGAGACAATGCCCTCACCTTATGGCAGAAGAAT AATTCCTGAAATTACAGCTATGAAGGCAGATGCCAGCAAAAAGTTGCTGAAGAAGAAGAAGGGTGATCTT GATACTGCAGCAGTAAAAGTGGAATTTGATGAAGAATTCAGTGGAGCACCAGTAGAAGGTGCAGGAGAAG AGGCATTGACTCCATCAGTTCCTATAAATAAAGGTCCCAAACCTAAGAGGGAGAAGAAGGAGCCTGGTAC CAGAGTGAGAAAAACACCTACATCATCTGGTAAACCTAGTGCAAAGAAAGTGAAGAAACGGAATCCTTGG TCAGATGATGAATCCAAGTCAGAAAGTGATTTGGAAGAAACAGAACCTGTGGTTATTCCAAGAGATTCTT TGCTTAGGAGAGCAGCAGCCGAAAGACCTAAATACACATTTGATTTCTCAGAAGAAGAGGATGATGATGC TGATGATGATGATGATGACAATAATGATTTAGAGGAATTGAAAGTTAAAGCATCTCCCATAACAAATGAT GGGGAAGATGAATTTGTTCCTTCAGATGGGTTAGATAAAGATGAATATACATTTTCACCAGGCAAATCAA AAGCCACTCCAGAAAAATCTTTGCATGACAAAAAAAGTCAGGATTTTGGAAATCTCTTCTCATTTCCTTC ATATTCTCAGAAGTCAGAAGATGATTCAGCTAAATTTGACAGTAATGAAGAAGATTCTGCTTCTGTTTTT TCACCATCATTTGGTCTGAAACAGACAGATAAAGTTCCAAGTAAAACGGTAGCTGCTAAAAAGGGAAAAC CGTCTTCAGATACAGTCCCTAAGCCCAAGAGAGCCCCAAAACAGAAGAAAGTAGTAGAGGCTGTAAACTC TGACTCGGATTCAGAATTTGGCATTCCAAAGAAGACTACAACACCAAAAGGTAAAGGCCGAGGGGCAAAG AAAAGGAAAGCATCTGGCTCTGAAAATGAAGGCGATTATAACCCTGGCAGGAAAACATCCAAAACAACAA GCAAGAAACCGAAGAAGACATCTTTTGATCAGGATTCAGATGTGGACATCTTCCCCTCAGACTTCCCTAC TGAGCCACCTTCTCTGCCACGAACCGGTCGGGCTAGGAAAGAAGTAAAATATTTTGCAGAGTCTGATGAA GAAGAAGATGATGTTGATTTTGCAATGTTTAAT ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >RC224802 representing NM_001068
Red=Cloning site Green=Tags(s) MAKSGGCGAGAGVGGGNGALTWVNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSV EPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKG IPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTW MNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPV NGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVV GKLIEVVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASN CGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLG VIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQ DGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYK GLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQF LYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEM SAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDN LLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKN FKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDT TVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRK EWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQ NQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEE LDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKKKGDL DTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPW SDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKASPITND GEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVF SPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAK KRKASGSENEGDYNPGRKTSKTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDE EEDDVDFAMFN TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Restriction Sites | SgfI-MluI Cloning Scheme for this gene Plasmid Map |
ACCN | NM_001068 |
ORF Size | 4863 bp |
OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers. |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_001068.1, NM_001068.2, NM_001068.3, NP_001059.2 |
RefSeq Size | 5189 bp |
RefSeq ORF | 4866 bp |
Locus ID | 7155 |
Cytogenetics | 3p24.2 |
Domains | DNA_gyraseB, DNA_topoisoIV, HATPase_c |
Protein Families | Druggable Genome |
MW | 182.5 kDa |
Gene Summary | 'This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]' |
Documents
Product Manuals |
FAQs |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
SC309899 | TOP2B (untagged)-Human topoisomerase (DNA) II beta 180kDa (TOP2B) |
USD 3,290.00 |
|
RG224802 | TOP2B (GFP-tagged) - Human topoisomerase (DNA) II beta 180kDa (TOP2B) |
USD 1,870.00 |
|
RC224802L3 | Lenti-ORF clone of TOP2B (Myc-DDK-tagged)-Human topoisomerase (DNA) II beta 180kDa (TOP2B) |
USD 1,900.00 |
|
RC224802L4 | Lenti-ORF clone of TOP2B (mGFP-tagged)-Human topoisomerase (DNA) II beta 180kDa (TOP2B) |
USD 1,900.00 |
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