Lubricin (PRG4) (NM_001127708) Human Tagged ORF Clone
CAT#: RC226389
- TrueORF®
PRG4 (Myc-DDK-tagged)-Human proteoglycan 4 (PRG4), transcript variant B. Note: ORF is codon optimized
"NM_001127708" in other vectors (2)
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Other products for "PRG4"
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | Myc-DDK |
Symbol | PRG4 |
Synonyms | CACP; HAPO; JCAP; MSF; SZP |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>RC226389 ORF sequence, codon optimized.
Due to the complexity of NM_001127708, the ORF clone is codon optimized for mammalian Expression. The nucleotide sequence differs from the reference sequence, yet the amino acid sequence remains identical. Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCTTGGAAGACCCTGCCAATTTATCTGCTCCTTCTGCTGAGCGTCTTTGTGATACAGCAGGTGAGTA GTCAGGAGCTCTCATGCAAGGGCAGGTGTTTCGAGTCTTTCGAGCGCGGACGGGAGTGCGATTGCGACGC TCAGTGCAAAAAGTATGACAAGTGCTGCCCTGACTACGAAAGCTTTTGCGCGGAGGTTCACAACCCCACA TCTCCGCCCTCAAGCAAAAAGGCCCCACCGCCTTCCGGCGCCTCCCAGACCATTAAGAGTACAACCAAAA GGAGCCCTAAACCACCAAACAAGAAAAAAACAAAAAAAGTTATAGAGTCAGAGGAAATCACCGAAGAGCA TAGTGTCTCCGAGAACCAGGAAAGTTCAAGCTCATCCAGCTCCTCCTCATCATCAAGTACCATCCGAAAA ATCAAGAGCTCCAAAAATTCCGCCGCAAATAGAGAGTTGCAGAAGAAGCTGAAAGTGAAGGATAACAAAA AAAACAGAACAAAAAAGAAACCCACCCCTAAACCACCGGTTGTGGATGAGGCCGGCTCTGGGCTGGACAA TGGAGACTTTAAAGTCACCACTCCAGACACGTCAACCACACAACACAACAAAGTAAGCACCTCACCAAAG ATAACCACAGCCAAGCCCATTAATCCACGGCCATCCTTGCCTCCTAACAGCGACACATCAAAAGAAACTT CTTTGACCGTGAACAAGGAAACCACGGTCGAGACCAAGGAAACTACAACCACTAATAAGCAGACCTCCAC CGACGGGAAGGAGAAGACCACTTCAGCTAAAGAGACACAGTCCATAGAGAAAACTTCTGCAAAAGATCTG GCACCAACGTCTAAGGTGCTCGCTAAACCGACTCCGAAAGCAGAAACCACCACAAAGGGTCCCGCTCTCA CTACTCCAAAGGAGCCAACACCTACCACACCCAAAGAACCCGCTTCAACCACACCTAAGGAGCCCACGCC CACCACAATTAAGTCCGCCCCGACTACACCCAAGGAGCCTGCCCCGACCACAACAAAATCTGCCCCTACT ACCCCGAAGGAGCCCGCTCCAACAACCACTAAGGAGCCCGCACCGACTACCCCTAAGGAACCCGCCCCTA CGACGACAAAGGAACCAGCTCCAACCACGACCAAGAGCGCTCCCACCACCCCTAAGGAGCCTGCCCCCAC AACTCCTAAGAAGCCGGCTCCTACAACCCCGAAGGAACCAGCCCCAACCACGCCAAAAGAACCCACTCCA ACAACCCCTAAAGAGCCAGCACCTACAACTAAAGAGCCTGCTCCGACAACCCCTAAGGAGCCTGCTCCTA CAGCCCCCAAAAAACCAGCGCCCACCACGCCCAAGGAGCCCGCTCCTACAACCCCCAAAGAACCAGCCCC AACCACTACTAAGGAACCGTCACCCACTACCCCAAAAGAACCGGCACCCACTACCACAAAATCAGCCCCC ACTACCACAAAAGAGCCAGCGCCAACCACTACCAAAAGTGCGCCTACTACACCGAAAGAGCCTAGCCCAA CCACTACAAAAGAACCGGCGCCCACAACTCCCAAAGAACCCGCTCCGACCACCCCTAAGAAACCAGCACC TACTACACCCAAGGAACCCGCCCCTACCACACCAAAAGAGCCAGCCCCCACCACAACGAAAAAACCCGCG CCTACCACACCCAAAGAACCCGCCCCCACTACTCCAAAGGAGACCGCTCCTACCACGCCAAAGAAACTGA CCCCCACTACGCCGGAGAAACTGGCACCAACCACCCCAGAGAAACCCGCCCCCACTACTCCCGAGGAACT CGCTCCGACGACACCCGAAGAACCCACGCCTACAACGCCTGAGGAGCCTGCCCCTACAACCCCAAAAGCC GCAGCGCCAAATACCCCCAAGGAACCTGCGCCGACTACTCCTAAGGAGCCCGCACCCACAACACCAAAGG AGCCAGCGCCGACAACTCCTAAAGAGACCGCTCCAACTACGCCTAAAGGGACTGCACCTACGACATTGAA AGAACCTGCGCCTACGACCCCTAAGAAACCTGCTCCCAAGGAACTCGCTCCCACTACCACAAAAGAGCCA ACGTCCACCACATGCGATAAACCAGCCCCGACCACTCCCAAGGGTACGGCTCCAACCACACCCAAGGAAC CTGCCCCAACTACACCGAAGGAGCCCGCCCCAACGACCCCAAAGGGGACTGCTCCTACTACGTTGAAAGA ACCAGCCCCCACAACACCAAAAAAACCCGCCCCCAAAGAGCTCGCCCCTACAACTACAAAGGGCCCTACT AGTACCACCAGTGACAAACCCGCACCAACAACCCCGAAAGAGACTGCCCCTACCACACCTAAGGAGCCGG CGCCTACCACCCCCAAAAAACCTGCCCCGACAACCCCTGAAACCCCTCCCCCAACAACAAGCGAGGTGTC AACCCCCACGACTACCAAGGAGCCCACTACCATTCACAAATCTCCTGATGAGAGCACCCCAGAGTTGAGT GCGGAGCCCACTCCGAAAGCTCTGGAAAATAGTCCAAAAGAGCCAGGTGTCCCCACTACAAAGACTCCTG CTGCTACCAAGCCCGAAATGACAACTACCGCCAAGGATAAAACCACCGAGCGAGATCTGCGGACAACACC CGAGACTACTACAGCCGCACCAAAAATGACGAAAGAAACAGCCACAACCACCGAAAAAACCACAGAGTCC AAGATAACCGCCACCACCACGCAAGTGACATCTACCACAACACAGGATACTACGCCCTTCAAAATCACCA CACTTAAAACAACTACACTGGCACCAAAGGTGACAACCACTAAGAAGACAATAACAACGACTGAGATAAT GAATAAGCCCGAAGAGACAGCGAAACCAAAGGACAGAGCTACCAATTCCAAAGCCACCACCCCAAAGCCA CAAAAACCAACAAAGGCACCCAAAAAGCCTACCAGTACCAAAAAACCAAAGACCATGCCTAGAGTACGGA AGCCCAAGACAACACCCACACCGCGCAAAATGACGAGCACTATGCCAGAACTTAATCCCACATCCCGGAT CGCAGAAGCTATGTTGCAGACCACTACCCGCCCCAATCAGACACCGAACAGTAAACTCGTCGAAGTCAAC CCCAAATCAGAGGATGCCGGAGGCGCCGAAGGGGAGACTCCACATATGCTCCTGCGACCGCATGTTTTTA TGCCTGAAGTGACCCCTGACATGGATTACCTTCCTAGGGTCCCTAATCAGGGTATCATCATCAATCCTAT GCTCAGTGATGAGACCAATATTTGTAACGGGAAACCAGTGGATGGACTGACAACACTGCGCAACGGCACA CTGGTTGCTTTTCGCGGTCATTATTTTTGGATGCTGTCCCCATTCTCACCACCATCCCCAGCTCGAAGGA TCACAGAGGTGTGGGGCATTCCTTCTCCAATTGACACCGTTTTCACCCGCTGCAATTGCGAAGGAAAAAC CTTCTTTTTCAAAGACAGTCAGTATTGGCGATTTACAAATGATATCAAAGACGCAGGGTATCCCAAGCCG ATCTTCAAAGGCTTCGGAGGCCTGACAGGCCAGATTGTTGCCGCTCTCTCCACCGCTAAGTACAAGAACT GGCCTGAATCCGTGTATTTCTTTAAGAGAGGGGGAAGCATTCAACAATATATCTATAAGCAGGAGCCCGT GCAGAAATGCCCAGGCAGACGGCCCGCTCTGAACTACCCAGTTTACGGCGAGACTACCCAGGTAAGGAGG AGGCGCTTCGAGAGAGCTATTGGGCCCTCCCAAACCCACACAATACGGATACAGTACTCTCCGGCAAGAC TGGCATACCAGGACAAGGGAGTGCTCCACAACGAGGTAAAGGTTAGCATATTGTGGCGGGGCTTGCCAAA CGTTGTAACATCTGCCATAAGCCTGCCCAACATTCGCAAGCCTGACGGATACGACTACTATGCATTTAGC AAAGATCAGTATTACAATATAGACGTGCCTTCCAGAACTGCCCGCGCAATTACCACCAGGTCCGGCCAGA CACTCTCCAAGGTGTGGTATAATTGCCCT ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >RC226389 representing NM_001127708
Red=Cloning site Green=Tags(s) MAWKTLPIYLLLLLSVFVIQQVSSQELSCKGRCFESFERGRECDCDAQCKKYDKCCPDYESFCAEVHNPT SPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRK IKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPK ITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDL APTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPT TPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTP TTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAP TTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKA AAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEP TSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPT STTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELS AEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTES KITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKP QKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVN PKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDETNICNGKPVDGLTTLRNGT LVAFRGHYFWMLSPFSPPSPARRITEVWGIPSPIDTVFTRCNCEGKTFFFKDSQYWRFTNDIKDAGYPKP IFKGFGGLTGQIVAALSTAKYKNWPESVYFFKRGGSIQQYIYKQEPVQKCPGRRPALNYPVYGETTQVRR RRFERAIGPSQTHTIRIQYSPARLAYQDKGVLHNEVKVSILWRGLPNVVTSAISLPNIRKPDGYDYYAFS KDQYYNIDVPSRTARAITTRSGQTLSKVWYNCP TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
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ACCN | NM_001127708 |
ORF Size | 4089 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001127708.1, NM_001127708.2, NP_001121180.1 |
RefSeq Size | 4927 |
RefSeq ORF | 4092 |
Locus ID | 10216 |
MW | 146.5 kDa |
Gene Summary | The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
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