ULBP4 (RAET1E) (NM_001243325) Human Tagged ORF Clone

CAT#: RC232202

RAET1E (Myc-DDK tagged) - Homo sapiens retinoic acid early transcript 1E (RAET1E), transcript variant 2

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: RAET1E
• Synonyms: bA350J20.7; LETAL; N2DL-4; NKG2DL4; RAET1E2; RL-4; ULBP4
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RC232202 representing NM_001243325
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGCGAAGAATATCCCTGACTTCTAGCCCTGTGCGCCTTCTTTTGTTTCTGCTGTTGCTACTAATAGCCT
  TGGAGATCATGTACAACAGTGACAACAACATGGTCAAACCTCTGGGCCTCCTGGGGAAGAAGGTATATGC
  CACCAGCACTTGGGGAGAATTGACCCAAACGCTGGGAGAAGTGGGGCGAGACCTCAGGATGCTCCTTTGT
  GACATCAAACCCCAGATAAAGACCAGTGATCCTTCCACTCTGCAAGTCGAGATGTTTTGTCAACGTGAAG
  CAGAACGGTGCACTGGTGCATCCTGGCAGTTCGCCACCAATGGAGAGAAATCCCTCCTCTTTGACGCAAT
  GAACATGACCTGGACAGTAATTAATCATGAAGCCAGTAAGATCAAGGAGACATGGAAGAAAGACAGAGGG
  CTGGAAAAGTATTTCAGGAAGCTCTCAAAGGGAGACTGCGATCACTGGCTCAGGGAATTCTTAGGGCACT
  GGGAGGCAATGCCAGAACCGACAGTGTCACCAGTAAATGCTTCAGATATCCACTGGTCTTCTTCTAGTCT
  ACCAGATAGATGGATCATCCTGGGGGCATTCATCCTGTTAGTTTTAATGGGAATTGTTCTCATCTGTGTC
  TGGTGGCAAAATGGTGAGTGGCAGGCTGGTCTCTGGCCCTTGAGGACGTCT
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
  Protein Sequence

  >RC232202 representing NM_001243325
  Red=Cloning site Green=Tags(s)
  
  MRRISLTSSPVRLLLFLLLLLIALEIMYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLRMLLC
  DIKPQIKTSDPSTLQVEMFCQREAERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRG
  LEKYFRKLSKGDCDHWLREFLGHWEAMPEPTVSPVNASDIHWSSSSLPDRWIILGAFILLVLMGIVLICV
  WWQNGEWQAGLWPLRTS
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_001243325
• ORF Size: 681 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001243325.1, NP_001230254.1
• RefSeq Size: 850
• RefSeq ORF: 684
• Locus ID: 135250
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Natural killer cell mediated cytotoxicity
• MW: 26.5 kDa
• Gene Summary: This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]