TAB2 (NM_001292035) Human Tagged ORF Clone

CAT#: RG239247

TAB2 (GFP-tagged) - Human TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2), transcript variant 4

Specifications

Product Data

• Tag: TurboGFP
• Symbol: TAB2
• Synonyms: CHTD2; MAP3K7IP2; TAB-2
• Vector: pCMV6-AC-GFP
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RG239247 representing NM_001292035.
  Blue=ORF Red=Cloning site Green=Tag(s)
  
  GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG
  GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC
  ATGCAGAATAATAATAACCTGGATGCCTGCTGTGCTGTTCTCTCTCAGGAGAGTACAAGATATCTTTAT
  GGTGAAGGAGACTTGAATTTTTCAGATGATTCTGGAATTTCTGGTCTACGCAATCACATGACTTCTCTC
  AACTTGGACTTGCAATCACAGAACATTTACCACCATGGAAGAGAAGGAAGTAGGATGAATGGAAGTAGG
  ACTCTAACGCACAGCATTAGTGATGGACAACTTCAAGGTGGCCAGTCCAATAGTGAACTATTTCAGCAG
  GAGCCACAGACAGCACCAGCTCAAGTTCCTCAAGGCTTTAATGTTTTTGGAATGTCCAGTTCCTCTGGT
  GCTTCAAATTCAGCACCACATCTTGGATTTCACTTAGGCAGCAAAGGAACATCTAGCCTTTCTCAACAA
  ACTCCCAGATTTAATCCCATTATGGTAACTTTAGCCCCAAATATCCAGACTGGTCGTAATACTCCTACA
  TCTTTGCACATACATGGTGTACCTCCACCTGTACTTAACAGTCCACAGGGAAATTCTATCTATATTAGG
  CCTTACATTACAACTCCTGGTGGTACAACTCGACAGACACAACAGCATTCTGGCTGGGTATCTCAGTTT
  AATCCCATGAACCCTCAGCAAGTTTATCAGCCTTCACAGCCTGGTCCCTGGACTACTTGTCCTGCATCT
  AATCCTCTGTCACATACCTCATCTCAACAGCCAAATCAGCAAGGCCACCAGACCTCTCATGTCTACATG
  CCAATCAGTTCACCTACTACTTCACAACCACCAACCATTCATTCATCTGGTAGCTCACAGTCTTCTGCC
  CATAGCCAATATAACATTCAGAATATTTCAACAGGACCTCGAAAAAACCAGATTGAAATCAAACTTGAA
  CCCCCACAAAGAAATAATTCTTCAAAACTGCGTTCTTCTGGACCTCGAACCTCCAGCACTTCCTCTTCA
  GTCAATAGCCAGACCTTAAACAGAAATCAGCCCACTGTTTACATAGCTGCCAGCCCCCCAAATACGGAT
  GAGCTGATGTCCCGTAGTCAACCTAAGGTCTATATTTCAGCGAATGCTGCCACAGGAGATGAACAGGTC
  ATGCGGAATCAGCCCACACTCTTCATATCCACAAACTCTGGAGCATCTGCTGCCTCCAGGAACATGTCT
  GGGCAAGTGAGCATGGGTCCTGCCTTTATTCATCACCATCCTCCCAAAAGTCGAGCAATAGGCAATAAC
  TCTGCAACCTCTCCTCGAGTGGTAGTCACTCAGCCCAATACGAAATACACTTTCAAAATTACAGTCTCT
  CCCAATAAGCCCCCTGCAGTTTCACCAGGGGTGGTGTCCCCTACCTTTGAACTTACAAATCTTCTTAAT
  CATCCTGATCATTATGTAGAAACCGAGAATATTCAGCACCTCACGGACCCTACATTAGCACATGTGGAT
  AGAATAAGTGAAACACGGAAACTGAGTATGGGATCTGATGATGCTGCCTACACACAAGCTCTTTTGGTA
  CACCAGAAGGCCAGAATGGAACGACTTCAAAGAGAACTTGAGATTCAAAAGAAAAAGCTGGATAAATTA
  AAATCTGAGGTTAATGAAATGGAAAATAATCTAACTCGAAGGCGCCTGAAAAGATCAAATTCTATATCC
  CAGATACCTTCCCTTGAAGAAATGCAGCAGCTGAGAAGTTGTAATAGACAACTCCAGATTGACATTGAC
  TGCTTAACCAAAGAAATTGATCTTTTTCAAGCCCGAGGACCACATTTTAACCCCAGCGCTATTCATAAC
  TTTTATGACAATATTGGATTTGTAGGTCCTGTGCCACCAAAACCCAAAGATCAAAGGTCCATCATCAAA
  ACACCAAAGACTCAAGACACAGAAGATGATGAGGGAGCTCAGTGGAATTGTACCGCCTGTACTTTTTTG
  AACCATCCAGCCTTAATTCGCTGTGAACAGTGTGAGATGCCAAGGCATTTC
  ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAAAC
  
  Protein Sequence

  >Peptide sequence encoded by RG239247
  Blue=ORF Red=Cloning site Green=Tag(s)
  
  MQNNNNLDACCAVLSQESTRYLYGEGDLNFSDDSGISGLRNHMTSLNLDLQSQNIYHHGREGSRMNGSR
  TLTHSISDGQLQGGQSNSELFQQEPQTAPAQVPQGFNVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQ
  TPRFNPIMVTLAPNIQTGRNTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQF
  NPMNPQQVYQPSQPGPWTTCPASNPLSHTSSQQPNQQGHQTSHVYMPISSPTTSQPPTIHSSGSSQSSA
  HSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSSTSSSVNSQTLNRNQPTVYIAASPPNTD
  ELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASRNMSGQVSMGPAFIHHHPPKSRAIGNN
  SATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTDPTLAHVD
  RISETRKLSMGSDDAAYTQALLVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSIS
  QIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSIIK
  TPKTQDTEDDEGAQWNCTACTFLNHPALIRCEQCEMPRHF
  TRTRPLEMESDESGLPAMEIECRITGTLNGVEFELVGGGEGTPEQGRMTNKMKSTKGALTFSPYLLSHV
  MGYGFYHFGTYPSGYENPFLHAINNGGYTNTRIEKYEDGGVLHVSFSYRYEAGRVIGDFKVMGTGFPED
  SVIFTDKIIRSNATVEHLHPMGDNDLDGSFTRTFSLRDGGYYSSVVDSHMHFKSAIHPSILQNGGPMFA
  FRRVEEDHSNTELGIVEYQHAFKTPDADAGEERV
  
• Restriction Sites: SgfI-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_001292035
• ORF Size: 1983 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.

Reference Data

• RefSeq: NM_001292035.3
• RefSeq Size: 4206 bp
• RefSeq ORF: 1986 bp
• Locus ID: 23118
• Cytogenetics: 6q25.1
• Protein Families: Druggable Genome
• Protein Pathways: MAPK signaling pathway, NOD-like receptor signaling pathway, Toll-like receptor signaling pathway
• MW: 73.3 kDa
• Gene Summary: The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]