Txnrd2 (NM_022584) Rat Untagged Clone

CAT#: RN207441

Txnrd2 (untagged ORF) - Rat thioredoxin reductase 2 (Txnrd2), nuclear gene encoding mitochondrial protein, (Note, selenocysteine protein, internal stop codon, see reference data summary)

Specifications

Product Data

• Type: Rat Untagged Clone
• Symbol: Txnrd2
• Synonyms: Tr3; Trxr2; Trxrd2
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >RN207441 representing NM_022584
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGCGGCGATTGTGGCGGCGCTGCGCGGATCCAGCGGGCGCTTCCGGCCGCAGACACGGGTTTTAACAC
  GCGGGACGCGGGGCGCGGCGGGCGCGGCGAGCGCAGCGGGAGGGCAGCAGAACTTTGATCTCTTGGTGAT
  CGGTGGGGGATCCGGTGGCCTAGCTTGTGCCAAGGAAGCGGCTCAGCTGGGAAGGAAGGTGGCTGTGGCT
  GACTATGTGGAACCCTCTCCCCGAGGCACCAAATGGGGCCTTGGTGGCACCTGTGTCAACGTGGGCTGCA
  TACCCAAGAAGCTGATGCATCAGGCCGCACTGCTGGGGGGCATGATCAGAGATGCTCAGCACTACGGCTG
  GGAGGTGGCCCAGCCTGTCCAGCACAACTGGAAGGCAATGGCCGAAGCCGTGCAAAACCATGTGAAGTCC
  TTGAACTGGGGTCATCGTGTCCAACTGCAGGACAGGAAAGTCAAGTACTTTAACATCAAAGCCAGCTTTG
  TCAACGAGCACACAGTTCACGGTGTCGACAAAGCCGGGAAGGTGACTCAGCTTTCAGCCAAGCACATAGT
  CATCGCTACAGGAGGACGGCCGAAGTACCCCACACAGGTCAAAGGAGCCCTGGAACACGGAATCACAAGT
  GATGACATCTTCTGGCTGAAGGAGTCCCCTGGGAAAACGTTGGTGGTTGGAGCCAGTTATGTGGCCCTGG
  AGTGTGCCGGCTTCCTCACTGGTATTGGCCTGGATACCACGGTCATGATGCGCAGCGTGCCCCTCCGAGG
  CTTTGACCAGCAAATGGCGTCTTTGGTCACAGAGCACATGGAGTCTCATGGCACCCGGTTCCTGAAAGGC
  TGTGTCCCCTCCCTCATCAGAAAACTCCCGACTAACCAACTGCAGGTCACTTGGGAGGATCTCGCTTCTG
  GCAAGGAGGACGTGGGCACCTTTGACACTGTCCTGTGGGCCATAGGGCGAGTTCCAGAGACCAGAAATTT
  GAATCTGGAGAAGGCTGGCGTTAATACCAACCCTAAGAATCAGAAGATCATTGTGGATGCCCAGGAGGCC
  ACCTCTGTCCCCCACATCTATGCCATTGGAGATGTTGCTGAGGGGCGGCCTGAGCTGACACCCACAGCTA
  TCAAGGCAGGAAAGCTTCTGGCTCAGCGGCTCTTTGGGAAATCCTCAACCTTAATGAATTACAGCAACGT
  CCCCACAACTGTCTTTACACCACTGGAGTATGGCTGTGTGGGACTGTCTGAGGAGGAGGCTGTGGCTCTC
  CACGGCCAGGAGCATATAGAGGTTTACCATGCATATTACAAGCCCCTAGAGTTCACAGTGGCAGATCGGG
  ATGCATCACAGTGCTACATAAAGATGGTATGCATGAGGGAGCCCCCACAACTGGTACTGGGCCTGCACTT
  CCTTGGCCCCAACGCTGGAGAAGTCACACAAGGATTTGCTCTTGGGATCCAGTGTGGGGCTTCATACGCA
  CAGGTGATGCAGACAGTAGGGATCCACCCCACCTGCTCTGAGGAGGTGGTTAAGCTGCACATCTCCAAGC
  GCTCTGGCCTGGATCCTACTGTGACTGGCTGCTGAGGTTAA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_022584
• ORF Size: 1581 bp
• Insert Size: 1581
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). The expression of this clone is not guaranteed due to the nature of selenoproteins.

Reference Data

• RefSeq: NM_022584.2, NP_072106.1
• RefSeq Size: 1989
• RefSeq ORF: 1581
• Locus ID: 50551
• Gene Summary: The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jun 2017]