Mapk8 (NM_053829) Rat Untagged Clone

CAT#: RN216642

Mapk8 (untagged) - Rat mitogen-activated protein kinase 8 (Mapk8)

Specifications

Product Data

• Type: Rat Untagged Clone
• Tag: Tag Free
• Symbol: Mapk8
• Synonyms: JNK
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >RN216642 representing NM_053829
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGAGCAGAAGTAAACGTGACAACAATTTTTATAGTGTAGAGATCGGAGATTCTACATTCACAGTCCTAA
  AACGATACCAGAACTTAAAGCCTATAGGCTCAGGAGCTCAAGGAATAGTGTGTGCAGCTTATGATGCTAT
  TCTTGAAAGAAATGTTGCAATCAAGAAGCTCAGCCGGCCATTTCAGAATCAGACCCATGCTAAGCGAGCC
  TACCGAGAACTAGTTCTTATGAAGTGTGTTAATCACAAAAATATAATTGGCCTTTTGAATGTTTTCACAC
  CACAGAAATCCCTAGAAGAATTTCAAGATGTTTACATAGTCATGGAGCTCATGGATGCAAATCTTTGCCA
  AGTGATTCAGATGGAGTTAGATCATGAAAGAATGTCCTACCTTCTCTATCAAATGCTGTGTGGAATCAAG
  CACCTTCACTCTGCTGGAATTATTCATCGGGACTTAAAGCCTAGTAATATAGTAGTCAAATCAGACTGCA
  CTTTGAAGATTCTTGATTTTGGACTGGCAAGGACTGCAGGAACGAGTTTTATGATGACGCCTTACGTGGT
  AACTCGTTACTACAGAGCACCAGAGGTCATTCTCGGCATGGGCTACAAGGAGAACGTGGATTTATGGTCT
  GTGGGGTGCATTATGGGAGAAATGGTTTGCCTCAAAATCCTCTTTCCAGGAAGGGACTATATTGATCAGT
  GGAATAAAGTTATTGAACAGCTCGGAACACCTTGTCCTGAATTCATGAAGAAACTACAACCAACAGTAAG
  GACTTACGTTGAAAACAGACCTAAGTACGCTGGCTATAGCTTTGAGAAACTGTTTCCTGATGTGCTTTTC
  CCAGCTGACTCAGAACATAACAAACTTAAAGCCAGTCAGGCGAGAGATTTGTTATCTAAAATGCTGGTGA
  TAGATGCGTCCAAAAGGATCTCCGTAGACGAAGCTCTCCAGCACCCGTACATCAACGTCTGGTATGATCC
  TTCAGAAGCAGAGGCCCCACCACCAAAGATCCCTGACAAGCAGTTAGATGAAAGGGAGCACACAATAGAG
  GAGTGGAAAGAACTGATATACAAGGAGGTCATGGATTTGGAGGAGCGAACTAAGAATGGCGTCATAAGAG
  GGCAGCCGTCTCCTTTAGGTGCAGCAGTGATCAATGGCTCTCAGCATCCGGTCTCTTCGCCGTCTGTCAA
  TGACATGTCTTCAATGTCCACAGATCCGACTCTGGCCTCGGATACAGACAGCAGTCTAGAAGCATCAGCT
  GGACCTCTGGGCTGCTGTAGATGA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_053829
• ORF Size: 1284 bp
• Insert Size: 1284
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This clone expresses the complete ORF with c-terminal tags of Myc-DDK.

Reference Data

• RefSeq: NM_053829.2, NP_446281.2
• RefSeq Size: 5796
• RefSeq ORF: 1284
• Locus ID: 116554
• Gene Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. [provided by RefSeq, Jul 2012]