Txnrd3 (NM_001106609) Rat Tagged ORF Clone

CAT#: RR217002

  • TrueORF®

Txnrd3 (myc-DDK-tagged) - Rat thioredoxin reductase 3 (Txnrd3), transcript variant 1


  "NM_001106609" in other vectors (1)

Reconstitution Protocol

USD 630.00

5 Weeks*

Size
    • 10 ug

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Specifications

Product Data
Type Rat Tagged ORF Clone
Tag Myc-DDK
Symbol Txnrd3
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>RR217002 representing NM_001106609
Red=Cloning site Blue=ORF Green=Tags(s)

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGTCGTCGCCACCCGGCCGCCGCGCCCGCCTGACGTCCCCCGGGACCAGCCGCCCGCCCGCTGAGGTCC
GCGAGGAGGTGCGGCGCCGCCTGCGGGATCTCATCGAGGGCAACAGGGTTATGATCTTCAGCAAGAGTTA
CTGTCCACACAGCTCGCGGGTTAAGGAACTCTTTTCATCCTTGGGAGTGAACTATTACATCCTGGAACTT
GATCAAGTTGATGATGGGGCCAATGTTCAGGAAGTGCTGACAGAAATCAGTAACCAGAAAACGGTGCCCA
ATATTTTTGTGAATAAAGTGCACGTGGGTGGATGTGACCGGATTTTCCAGGCACATCAGAATGGTTTACT
GCAGAAGCTCCTTCAGGATGACTCAACTCATGATTATGATCTCATCGTCATCGGCGGGGGCTCTGGCGGC
CTCTCTTGTGCCAAGGAAGCTGCCAACTTGGGAAAGAAGGTCATGGTGCTAGACTTTGTGGTTCCCTCGC
CTCAGGGCACGTCCTGGGGCCTTGGCGGCACCTGTGTGAATGTAGGCTGTATCCCTAAGAAGCTGATGCA
TCAGGCAGCCCTCCTGGGGCATGCTCTGCAAGATGCGAGGAAATATGGCTGGGATTATAACCAGCAGGTG
AAGCACAACTGGGAGACCATGAGGGAAGCGATCCAGAACCACATTGGCTCCTTGAACTGGGGCTACAGGG
TAACTCTTCGGGAGAAAGGCGTGACCTATGTCAACTCCTTCGGGGAGTTTGTGGAACTGCATAAAATAAA
GGCAACCAATAAGAAAGGGCAGGAAACTTTTTACACCGCTTCGAAGTTTGTCATAGCAACAGGGGAAAGG
CCGCGGTACTTGGGAATCCAGGGAGATAAAGAGTACTGTATTACCAGCGACGACCTGTTCTCTCTGCCAT
ACTGCCCAGGGAACACATTAATCGTTGGCGCCTCGTATGTTGGTCTGGAGTGTGCAGGCTTTTTGGCTGG
CTTGGGGCTAGATGTGACAGTCATGGTACGCTCTGTCCTTCTTCGTGGCTTTGATCAAGAAATGGCAGAG
AAAGTGGGATCCTACCTGGAACAACAAGGCGTCAAGTTCCAAAGGAAATTCACCCCCATTTTGGTTCAAC
AGTTGGAGAAAGGCTTACCCGGAAGATTGAAAGTCGTGGCTAAGTCCACTGAAGGACCAGAGACAGTAGA
AGGGACATACAACACGGTTTTGTTAGCAATTGGTCGTGACTCCTGTACAAGGAAAATAGGGCTGGAGAAG
ATCGGGGTCAAAATCAATGAGAAGAATGGCAAAATACCAGTAAATGATGTGGAACAGACCAATGTGCCTC
ATGTTTATGCTATTGGGGACGTACTGGAGGGCAAACCAGAGCTCACACCTGTTGCCATACAGGCAGGCAA
GCTGCTAGCTCGAAGACTCTTTGGGATCTCTTTAGAAAAGTGTGATTACATTAACGTCCCAACAACGGTG
TTCACACCTCTGGAATACGGCTGTTGTGGACTGTCTGAAGAGAAAGCCATTGAAATGTATACGAAGGAGA
ATCTGGAAGTGTATCACACCTTCTTTTGGCCTCTTGAGTGGACAGTTGCTGGCAGAGACAACAACACCTG
TTATGCAAAGATAATCTGCAACAAATTTGACAATGACCGTGTGATAGGATTTCACCTCCTGGGGCCAAAT
GCTGGTGAAGTCACACAGGGGTTTGCAGCTGCAATGAAATGTGGGCTTACGAAGCAGCTACTGGATGACA
CCATTGGAATCCACCCCACCTGTGGTGAGGTATTTACAACCATGGAAATCACAAAGTCCTCAGGGCTGGA
CATTACTCAGAAAGGCTGCTGAGGC


ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAG
GTTTAA
>RR217002 representing NM_001106609
Red=Cloning site Green=Tags(s)

MSSPPGRRARLTSPGTSRPPAEVREEVRRRLRDLIEGNRVMIFSKSYCPHSSRVKELFSSLGVNYYILEL
DQVDDGANVQEVLTEISNQKTVPNIFVNKVHVGGCDRIFQAHQNGLLQKLLQDDSTHDYDLIVIGGGSGG
LSCAKEAANLGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGHALQDARKYGWDYNQQV
KHNWETMREAIQNHIGSLNWGYRVTLREKGVTYVNSFGEFVELHKIKATNKKGQETFYTASKFVIATGER
PRYLGIQGDKEYCITSDDLFSLPYCPGNTLIVGASYVGLECAGFLAGLGLDVTVMVRSVLLRGFDQEMAE
KVGSYLEQQGVKFQRKFTPILVQQLEKGLPGRLKVVAKSTEGPETVEGTYNTVLLAIGRDSCTRKIGLEK
IGVKINEKNGKIPVNDVEQTNVPHVYAIGDVLEGKPELTPVAIQAGKLLARRLFGISLEKCDYINVPTTV
FTPLEYGCCGLSEEKAIEMYTKENLEVYHTFFWPLEWTVAGRDNNTCYAKIICNKFDNDRVIGFHLLGPN
AGEVTQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTMEITKSSGLDITQKGC*G

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Restriction Sites SgfI-MluI      Cloning Scheme for this gene      Plasmid Map     
ACCN NM_001106609
ORF Size 1845 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_001106609.2, NP_001100079.2
RefSeq Size 2799
RefSeq ORF 1848
Locus ID 297437
MW 67.8 kDa
Gene Summary The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes the third TrxR, which unlike the other two isozymes, contains an additional N-terminal glutaredoxin (Grx) domain, and shows highest expression in testis. The Grx domain allows this isozyme to participate in both Trx and glutathione systems. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. There is evidence for two isoforms resulting from the use of a non-AUG (CUG), and an in-frame downstream AUG as translation initiation codons (PMID:20018845). [provided by RefSeq, Aug 2017]

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.