SLC19A3 (NM_025243) Human Untagged Clone

CAT#: SC108121

SLC19A3 (untagged)-Human solute carrier family 19, member 3 (SLC19A3)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SLC19A3
• Synonyms: BBGD; THMD2; THTR2
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC108121 sequence for NM_025243 edited (data generated by NextGen Sequencing)
  ATGGATTGTTACAGAACTTCACTAAGCAGTTCCTGGATTTACCCCACTGTGATCCTCTGC
  TTATTTGGTTTTTTCTCCATGATGAGACCCTCAGAACCATTCCTTATCCCATATTTATCT
  GGACCAGATAAAAACCTGACCAGTGCAGAGATAACAAATGAGATCTTCCCCGTTTGGACA
  TACTCCTACCTGGTGCTGCTGCTGCCTGTGTTTGTCCTCACCGATTATGTCCGCTACAAG
  CCAGTCATCATCTTGCAAGGTATCAGTTTCATCATTACCTGGCTGCTGCTGTTGTTTGGC
  CAAGGAGTGAAGACCATGCAGGTTGTAGAGTTCTTCTATGGGATGGTCACCGCCGCCGAG
  GTGGCCTACTACGCCTACATATACAGCGTGGTCAGCCCCGAGCACTACCAGAGAGTGAGC
  GGCTACTGCAGGAGCGTCACGCTGGCCGCCTACACAGCAGGGTCGGTGCTGGCTCAACTC
  TTGGTATCCCTGGCGAACATGTCGTACTTTTACCTCAACGTCATATCCTTGGCCTCTGTC
  TCCGTGGCTTTCCTTTTCTCACTTTTCCTACCAATGCCCAAGAAAAGCATGTTTTTTCAT
  GCAAAACCCAGCAGAGAAATAAAGAAGTCATCAAGCGTGAATCCAGTATTAGAGGAAACT
  CACGAAGGTGAAGCACCAGGCTGTGAAGAGCAGAAACCCACATCAGAAATACTCAGCACT
  TCAGGGAAGCTGAATAAGGGCCAGCTGAACAGCCTGAAACCAAGCAATGTGACTGTGGAC
  GTTTTTGTGCAGTGGTTCCAAGATTTGAAGGAGTGCTACTCCTCAAAACGTCTTTTCTAC
  TGGTCTCTATGGTGGGCTTTCGCCACAGCAGGTTTTAACCAGGTTTTGAACTATGTTCAA
  ATCCTGTGGGATTACAAGGCGCCATCCCAAGATTCTTCCATCTATAATGGGGCCGTAGAA
  GCTATTGCAACCTTTGGAGGGGCTGTGGCTGCCTTTGCAGTGGGTTATGTGAAAGTCAAC
  TGGGACCTTCTGGGAGAGCTGGCTCTGGTGGTCTTCTCAGTTGTCAATGCCGGTTCTTTA
  TTTCTCATGCATTACACAGCCAATATCTGGGCGTGCTATGCTGGCTATTTGATATTCAAG
  TCCAGCTATATGCTTCTTATAACCATAGCAGTATTTCAGATTGCAGTTAATCTGAATGTG
  GAACGCTATGCCTTGGTATTTGGAATCAACACCTTTATTGCCTTGGTGATTCAGACCATC
  ATGACTGTGATTGTAGTAGATCAGAGAGGGCTCAACTTGCCAGTCAGCATTCAGTTTTTA
  GTTTATGGGAGCTATTTTGCAGTAATTGCTGGAATTTTCCTAATGAGAAGCATGTATATT
  ACCTACTCAACCAAATCCCAGAAGGATGTACAGAGCCCTGCTCCAAGTGAGAATCCAGAT
  GTGTCTCACCCAGAGGAAGAGAGTAATATCATCATGTCAACAAAACTCTAA
  
  Clone variation with respect to NM_025243.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_025243 unedited
  NGGTTTCAGATTTTGTAACACGATCTCACTATAGGGCGGCCGCGAATTCGCACCAGGGCA
  AGTGAGCGATTTGGTGAACAGACACTCCCTTCTGTAGCCATGGATTGTTACAGAACTTCA
  CTAAGCAGTTCCTGGATTTACCCCACTGTGATCCTCTGCTTATTTGGTTTTTTCTCCATG
  ATGAGACCCTCAGAACCATTCCTTATCCCATATTTATCTGGACCAGATAAAAACCTGACC
  AGTGCAGAGATAACAAATGAGATCTTCCCCGTTTGGACATACTCCTACCTGGTGCTGCTG
  CTGCCTGTGTTTGTCCTCACCGATTATGTCCGCTACAAGCCAGTCATCATCTTGCAAGGT
  ATCAGTTTCATCATTACCTGGCTGCTGCTGTTGTTTGGCCAAGGAGTGAAGACCATGCAG
  GTTGTAGAGTTCTTCTATGGGATGGTCACCGCCGCCGAGGTGGCCTACTACGCCTACATA
  TACAGCGTGGTCAGCCCCGAGCACTACCAGAGAGTGAGCGGCTACTGCAGGAGCGTCACG
  CTGGCCGCCTACACAGCAGGGTCGGTGCTGGCTCAACTCTTGGTATCCCTGGCGAACATG
  TCGTACTTTTACCTCAACGTCATATCCTTGGCCTCTGTCTCCGTGGCTTTCCTTTTCTCA
  CTTTTCCTACCAATGCCCAAGAAAAGCATGTTTTTTCATGCANAACCCAGCAGAGAAATA
  AAGAAGTCATCAAGCGTGAATCCAGTATTAGAGGAAACTCACGAAGGTGAAGCACCAGGC
  TGTGAAGAGCAGAAACCCACATCAGAATACTCAGCACTTCAGGGAAGCTNGATAAGGGCC
  AGCTGAACAGCCTGAAACCAAGCATGTGACTGTGGACGTTTTGTGCAGTGGTCCAAGATT
  TGAAGAGTGCTACTCTCAA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_025243 unedited
  ATCGAGTTTTAAATTCTTTTTTTTTGTAAAAAAAGGGTTTAATTAGCTCACAGGCTATAT
  AGGAAGCGTGGCAACATCTGCTTCTAGGGAGTCCTCAGGGAATTTTTACTCATGGCAGAA
  GGCAAAGTGGGAGCAGGCATCTTCACGTGGCCAAAGCAGGAGAAAGAGAGAGTGGGGAGG
  TGCTACACACTTTTAAACTACCAGATCTCACGATAACTCACTGTCATGAGACCAGCACTG
  AGGGGACGGTGCCAAACCATTCATGAAGGCTTCACACCCATGATCCAGTCGCCTCCCAGC
  CGGCCCCACCTCTAACATTGGGGATTACACTTCAACGTGAGATTTGGTGGGGACACAGAT
  CCAAACCATATCAAAATCCAATTAAAAATTTTTTTGTTTGTTTTAGACACAGGGTCTTGC
  TATATTGGCCAAGATGGTCTCATACCCCTACCCTCAAATTAACCTCTCACTTCAGCCTCC
  CAAAATGCTGGGATTACAGGTGTGAGCCAAAGCTTTCCAGCCTGATATAAATCTTGACTC
  AGCATTTCTTATTCTCACTGTCAGACTGCTCAATGCATCCCTTATTGAAGTTTCTTTGAA
  GTTTTCGAAAACAGGTATGTTCAGATAATTTTCAGCAGAATTCATCANANAATGTTAAAC
  ACTGCTTAAAATTTTACACATTTTATTTAGCACAATTGCTACCATTTAAAAATCANNGTG
  TTTTGCCAGCATGGGGGGGGCTCACGCCCTGTTATCTCAGCTCTTTTGGGAGGGCCGAGG
  CAGACAGATCACCTGAAGTCAGGAGTTTNTGAGACCAGNNCTGGCCAACATTGTGAAACC
  CCATCTCACTAAATACAAATCGGGGGG
  
• Restriction Sites: ECoRI-NOT
• ACCN: NM_025243
• ORF Size: 1491 bp
• Insert Size: 4000
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_025243.2, NP_079519.1
• RefSeq Size: 3532
• RefSeq ORF: 1491
• Locus ID: 80704
• Domains: Folate_carrier
• Protein Families: Transmembrane
• Gene Summary: This gene encodes a ubiquitously expressed transmembrane thiamine transporter that lacks folate transport activity. Mutations in this gene cause biotin-responsive basal ganglia disease (BBGD); a recessive disorder manifested in childhood that progresses to chronic encephalopathy, dystonia, quadriparesis, and death if untreated. Patients with BBGD have bilateral necrosis in the head of the caudate nucleus and in the putamen. Administration of high doses of biotin in the early progression of the disorder eliminates pathological symptoms while delayed treatment results in residual paraparesis, mild cognitive disability, or dystonia. Administration of thiamine is ineffective in the treatment of this disorder. Experiments have failed to show that this protein can transport biotin. Mutations in this gene also cause a Wernicke's-like encephalopathy. [provided by RefSeq, Jan 2010]