SLC19A3 (NM_025243) Human Untagged Clone

CAT#: SC324186

SLC19A3 (untagged)-Human solute carrier family 19, member 3 (SLC19A3)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SLC19A3
• Synonyms: BBGD; THMD2; THTR2
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_025243.3 CGGCAAGTGAGCGATTTGGTGAACAGACACTCCCTTCTGTAGCCATGGATTGTTACAGAA
  CTTCACTAAGCAGTTCCTGGATTTACCCCACTGTGATCCTCTGCTTATTTGGTTTTTTCT
  CCATGATGAGACCCTCAGAACCGTTCCTTATCCCATATTTATCTGGACCAGATAAAAACC
  TGACCAGTGCAGAGATAACAAATGAGATCTTCCCCGTTTGGACATACTCCTACCTGGTGC
  TGCTGCTGCCTGTGTTTGTCCTCACCGATTATGTCCGCTACAAGCCAGTCATCATCTTGC
  AAGGTATCAGTTTCATCATTACCTGGCTGCTGCTGTTGTTTGGCCAAGGAGTGAAGACCA
  TGCAGGTTGTAGAGTTCTTCTATGGGATGGTCACCGCCGCCGAGGTGGCCTACTACGCCT
  ACATATACAGCGTGGTCAGCCCCGAGCACTACCAGAGAGTGAGCGGCTACTGCAGGAGCG
  TCACGCTGGCCGCCTACACAGCAGGGTCGGTGCTGGCTCAACTCTTGGTATCCCTGGCGA
  ACATGTCGTACTTTTACCTCAACGTCATATCCTTGGCCTCTGTCTCCGTGGCTTTCCTTT
  TCTCACTTTTCCTACCAATGCCCAAGAAAAGCATGTTTTTTCATGCAAAACCCAGCAGAG
  AAATAAAGAAGTCATCAAGCGTGAATCCAGTATTAGAGGAAACTCACGAAGGTGAAGCAC
  CAGGCTGTGAAGAGCAGAAACCCACATCAGAAATACTCAGCACTTCAGGGAAGCTGAATA
  AGGGCCAGCTGAACAGCCTGAAACCAAGCAATGTGACTGTGGACGTTTTTGTGCAGTGGT
  TCCAAGATTTGAAGGAGTGCTACTCCTCAAAACGTCTTTTCTACTGGTCTCTATGGTGGG
  CTTTCGCCACAGCAGGTTTTAACCAGGTTTTGAACTATGTTCAAATCCTGTGGGATTACA
  AGGCGCCATCCCAAGATTCTTCCATCTATAATGGGGCCGTAGAAGCTATTGCAACCTTTG
  GAGGGGCTGTGGCTGCCTTTGCAGTGGGTTATGTGAAAGTCAACTGGGACCTTCTGGGAG
  AGCTGGCTCTGGTGGTCTTCTCAGTTGTCAATGCCGGTTCTTTATTTCTCATGCATTACA
  CAGCCAATATCTGGGCGTGCTATGCTGGCTATTTGATATTCAAGTCCAGCTATATGCTTC
  TTATAACCATAGCAGTATTTCAGATTGCAGTTAATCTGAATGTGGAACGCTATGCCTTGG
  TATTTGGAATCAACACCTTTATTGCCTTGGTGATTCAGACCATCATGACTGTGATTGTAG
  TAGATCAGAGAGGGCTCAACTTGCCAGTCAGCATTCAGTTTTTAGTTTATGGGAGCTATT
  TTGCAGTAATTGCTGGAATTTTCCTAATGAGAAGCATGTATATTACCTACTCAACCAAAT
  CCCAGAAGGATGTACAGAGCCCTGCTCCAAGTGAGAATCCAGATGTGTCTCACCCAGAGG
  AAGAGAGTAATATCATCATGTCAACAAAACTCTAACCTCATCGCAACAAACGCAACAGTG
  GCTTTCAAAGTTATGCAATAATAAGGAAAGATTTTGAGATGGGTGGCATATGTTTTGCCA
  TAACTTGACATGCTTTGCAAATCTGGATTCCAATGGACCTTTCAAAACCACAACAAAACC
  TCAGTTTTAGATGAGTTCTCTATGTGACCAATTTTACTGGATGCAATTGACAGGACCCGT
  CATCATAATTAAACAACCCATATTGGGGACCCCCTGTGACTAGTAGCAGCTGGAAAATTC
  TGGTTTTTATCACTTGTAAAGACATGCAGATGGCGTGGAACCAAACCATGAGAAAACTCC
  AGCCATCCTGGAGTTGATATTCACCATTTGTGAGGAGAAATACTAACTGGACTGACCCTA
  TTGCTAGGCTTAAATACTTATTTGATCTTACCAAAGAAGTCAACACATGGGACCTTTGTG
  TCACATGAACCATTTTCTTTCCTCTTCTATTAAGTGTATTTCTGTTTAAGTTACAGTTCT
  CTAAGAGAATTACAATGTTTGTCCCATTTCTAAGGGCTTCTCTTCAACTCTAATAACAGC
  ATTATTCACGTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_025243.3 unedited
  GGCGTTTGTATACGACTCCTATAGGGCGGCCGGCGATCGCGGCGCGCCGGTACCGGTCCG
  GAATTCCCGGGATCGGCAAGTGAGCGATTTGGTGAACAGACACTCCCTTCTGTAGCCATG
  GATTGTTACAGAACTTCACTAAGCAGTTCCTGGATTTACCCCACTGTGATCCTCTGCTTA
  TTTGGTTTTTTCTCCATGATGAGACCCTCAGAACCGTTCCTTATCCCATATTTATCTGGA
  CCAGATAAAAACCTGACCAGTGCAGAGATAACAAATGAGATCTTCCCCGTTTGGACATAC
  TCCTACCTGGTGCTGCTGCTGCCTGTGTTTGTCCTCACCGATTATGTCCGCTACAAGCCA
  GTCATCATCTTGCAAGGTATCAGTTTCATCATTACCTGGCTGCTGCTGTTGTTTGGCCAA
  GGAGTGAAGACCATGCAGGTTGTAGAGTTCTTCTATGGGATGGTCACCGCCGCCGAGGTG
  GCCTACTACGCCTACATATACAGCGTGGTCAGCCCCGAGCACTACCAGAGAGTGAGCGGC
  TACTGCAGGAGCGTCACGCTGGCCGCCTACACAGCAGGGTCGGTGCTGGCTCAACTCTTG
  GTATCCCTGGCGAACATGTCGTACTTTTACCTCAACGTCATATCCTTGGCCTCTGTCTCC
  GTGGCTTTCCTTTTCTCACTTTTCCTACCAATGCCCAAGAAAAGCATGTTTTTTCATGCA
  AAACCCAGCAGAGAAATAAAGAAGTCATCAAAGCGTGAATCCAGTATTAGAGGAACTCAC
  GAAGTGAAGCACCAGCTGTGAAGAGCAGAACCCACATCAGAAATACTCAGCACTTCAGGG
  AGCTGAATAAGGCCCAGCTGAACAGCCTGAAACCAAGCATGTGACTGTGACGTTTTGTGC
  AGTGTCAAGATTTGACGGAGTGCTACTCCTCAAACGTCTTTTCTAACTGGTTCTTA
• Restriction Sites: ECoRI-NOT
• ACCN: NM_025243
• ORF Size: 1491 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_025243.3, NP_079519.1
• RefSeq Size: 3775
• RefSeq ORF: 1491
• Locus ID: 80704
• Domains: Folate_carrier
• Protein Families: Transmembrane
• Gene Summary: This gene encodes a ubiquitously expressed transmembrane thiamine transporter that lacks folate transport activity. Mutations in this gene cause biotin-responsive basal ganglia disease (BBGD); a recessive disorder manifested in childhood that progresses to chronic encephalopathy, dystonia, quadriparesis, and death if untreated. Patients with BBGD have bilateral necrosis in the head of the caudate nucleus and in the putamen. Administration of high doses of biotin in the early progression of the disorder eliminates pathological symptoms while delayed treatment results in residual paraparesis, mild cognitive disability, or dystonia. Administration of thiamine is ineffective in the treatment of this disorder. Experiments have failed to show that this protein can transport biotin. Mutations in this gene also cause a Wernicke's-like encephalopathy. [provided by RefSeq, Jan 2010]