SOCS2 (NM_003877) Human Untagged Clone

CAT#: SC108265

SOCS2 (untagged)-Human suppressor of cytokine signaling 2 (SOCS2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SOCS2
• Synonyms: CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC108265 sequence for NM_003877 edited (data generated by NextGen Sequencing)
  ATGACCCTGCGGTGCCTTGAGCCCTCCGGGAATGGCGGGGAAGGGACGCGGAGCCAGTGG
  GGGACCGCGGGGTCGGCGGAGGAGCCATCCCCGCAGGCGGCGCGTCTGGCGAAGGCCCTG
  CGGGAGCTCGGTCAGACAGGATGGTACTGGGGAAGTATGACTGTTAATGAAGCCAAAGAG
  AAATTAAAAGAGGCACCAGAAGGAACTTTCTTGATTAGAGATAGCTCGCATTCAGACTAC
  CTACTAACAATATCTGTTAAAACATCAGCTGGACCAACTAATCTTCGAATCGAATACCAA
  GACGGAAAATTCAGATTGGACTCTATCATATGTGTCAAATCCAAGCTTAAACAATTTGAC
  AGTGTGGTTCATCTGATCGACTACTATGTTCAGATGTGCAAGGATAAGCGGACAGGTCCA
  GAAGCCCCCCGGAACGGCACTGTTCACCTTTATCTGACCAAACCGCTCTACACGTCAGCA
  CCATCTCTGCAGCATCTCTGTAGGCTCACCATTAACAAATGTACCGGTGCCATCTGGGGA
  CTGCCTTTACCAACAAGACTAAAAGATTACTTGGAAGAATATAAATTCCAGGTATAA
  
  Clone variation with respect to NM_003877.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003877 unedited
  TTCAAATTTGTATACGACTCCTATAGGGCGGCCGCGAATTCGCACGAGGTTTAACTCTTG
  CCAAGTCTCGTCGCAGCCGCCGCGGCTGGCGGGCCTTGGGCTTCCCCTGAAGCATGAGCC
  CTCTCGCCCGCAGCCACCCTCACCGCGTGGCCCGCGGACAGTGCGCGCCGGGGTCCCGGG
  TGCACAGCCTCAGGATACCCCGTGCCCGCAGCTCGGGCGCCCGCGGCAGGCGATCAGTGG
  GTGACCGCGGCTGCGAGGGACTTTGTCATCCGTCCTCCAGGATCTGGGGAGAAAGAGCCC
  CATCCCTTCTCTCTCTGCCACCATTTCGGACACCCCGCAGGGACTCGTTTTGGGATTCGC
  ACTGACTTCAAGGAAGGACGCGAACCCTTCTCTGACCCCAGCTCGGGCGGCCACCTGTCT
  TTGCCGCGGTGACCCTTCTCTCATGACCCTGCGGTGCCTTGAGCCCTCCGGGAATGGCGG
  GGAAGGGACGCGGAGCCAGTGGGGGACCGCGGGGTCGGCGGAGGAGCCATCCCCGCAGGC
  GGCGCGTCTGGCGAAGGCCCTGCGGGAGCTCGGTCAGACAGGATGGTACTGGGGAAGTAT
  GACTGTTAATGAAGCCAAAGAGAAATTAAAAGAGGCACCAGAAGGAACTTTCTTGATTAG
  AGATAGCTCGCATTCAGACTACCTACTAACAATATCTGTTAAAACATCAGCTGGACCAAC
  TAATCTTCGAATCGAATACCAAGACGGAAAATTCAGATTGGACTCTATCATATGTGTCAA
  ATCCAAGCTTAAACATNTGACAGTGTGGGTCATCTGATCACTACTATGTTCAGATGTGCA
  AGGATAAGGGGACAGGTNCAGAAGCCCCCGGAACGGCACTGGTCACCTTNTCTGACCCAA
  CGCTCTAACGTNAGCACATCTCTGAGCATCTCTGTAGGCTACATTACAAAGTTACCGTGC
  ATCTTGGGGGACTNCTTTACACAGAAT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003877 unedited
  AGCCCGCATTTTAGNATCGAGTTTTTTTTTTTTTTTTTTAAAAATAGGTTTTTTTTATTT
  AATACATTCTAATCAAATAGTAACAGCAGTAAATAAACACTTTGAAAAACAGGCAGGTAT
  CCCCCTGTATCTGGAAGAAAATTAAGTCAAAGTATTCTACACAGTAGAAGGGAGACAACT
  GTTTATGTCCATGGTTAGACAATTCAAGGACAACTTGGATATTTCTAAAGCCATTTCCAA
  AAAATCAATGGCAACAGGTTGGGACACAGCTATTTCAAAGGGTAGAATGCCTATACCTAC
  ATTGGTTTTTATTAACGGGGATTGAGTTGCACCTGTATAGCATGATATTCTTGTCTTTAG
  CTTTAAAGGAAAAGAGAAAGTCTTTTCCATTTGCACCAGTTTGAAATATTTCTGAAATAA
  GGCTCCCATAGAATGGATTACTACAGTACTCATTCACATGAGAGTTCCTACATGTAGTAA
  AAAGACAAATACAGGACTTCATGGTCACTTTTTTTGGTTGATTTGGTTAATTGCATAAAA
  TGGGATAAATACTCACATACATCATCTGTTTAACAAAACTCCTAGGTACATCAGAATGCA
  AAATATAAAATGCCCAAGAGACTCTGATCAGCAGGCATATCAAATTGCAGTGAGGCCTGT
  GTCAGCTTGGTTCCTTCCCACTTCTTCAGTATTCCTATGANGAGTTCTTTCTCTCCTACT
  GGAGCCTGGACCTTTGACATAATGGAAAAGAACCTAAGAAAGCAAGGCATTCTGATAAAA
  CGCGACTTCAGCCTTTACATGCGACATTNTATTTTTAATCTAANAGGATCACACAGTCTT
  GGCCAGCCTTTAGACGGAAACATCACTCAGGTAAAAGTATCTGGAGGAACTTTAACCACT
  TACTACCTCTTCAAGCCTGTTAATTCAAATAGATTACCTTCAGCTGTTCTTAGAAGCATT
  CCTTATGNTTCCACACACTCAGTTTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003877
• ORF Size: 597 bp
• Insert Size: 1960
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_003877.3, NP_003868.1
• RefSeq Size: 2210
• RefSeq ORF: 597
• Locus ID: 8835
• Domains: SH2, SOCS
• Protein Families: Druggable Genome
• Protein Pathways: Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus
• Gene Summary: This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
  Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 5. Variants 1-6 encode the same protein.