SOCS2 (NM_003877) Human Untagged Clone

CAT#: SC320892

SOCS2 (untagged)-Human suppressor of cytokine signaling 2 (SOCS2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SOCS2
• Synonyms: CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003877.3 GGGGCAGTGGGTGACCGCGGCTGCGAGGGACTTTGTCATCGGTCCTCCAGGATCTGGGGA
  GAAAGAGCCCCATCCCTTCTCTCTCTGCCACCATTTCGGACACCCCGCAGGGACTCGTTT
  TGGGATTCGCACTGACTTCAAGGAAGGACGCGAACCCTTCTCTGACCCCAGCTCGGGCGG
  CCACCTGTCTTTGCCGCGGTGACCCTTCTCTCATGACCCTGCGGTGCCTTGAGCCCTCCG
  GGAATGGCGGGGAAGGGACGCGGAGCCAGTGGGGGACCGCGGGGTCGGCGGAGGAGCCAT
  CCCCGCAGGCGGCGCGTCTGGCGAAGGCCCTGCGGGAGCTCGGTCAGACAGGATGGTACT
  GGGGAAGTATGACTGTTAATGAAGCCAAAGAGAAATTAAAAGAGGCACCAGAAGGAACTT
  TCTTGATTAGAGATAGCTCGCATTCAGACTACCTACTAACAATATCTGTTAAAACATCAG
  CTGGACCAACTAATCTTCGAATCGAATACCAAGACGGAAAATTCAGATTGGACTCTATCA
  TATGTGTCAAATCCAAGCTTAAACAATTTGACAGTGTGGTTCATCTGATCGACTACTATG
  TTCAGATGTGCAAGGATAAGCGGACAGGTCCAGAAGCCCCCCGGAACGGCACTGTTCACC
  TTTATCTGACCAAACCGCTCTACACGTCAGCACCATCTCTGCAGCATCTCTGTAGGCTCA
  CCATTAACAAATGTACCGGTGCCATCTGGGGACTGCCTTTACCAACAAGACTAAAAGATT
  ACTTGGAAGAATATAAATTCCAGGTATAAATGTTTCTCTTTTTTTAAACATGTCTCACAT
  AGAGTATCTCCGAATGCAGCTATGTAAAAGAGAACCAAAACTTGAGTGCTCTGGATAACT
  ATATGGAATGCTTTCTAAGAACAGCTGAAGCTAATCTAATTTAAATTTAACAGCTTGAAG
  AGGTAGCTAGGTGTTTAAAGTTCCTCCAGATACTTTTACCTGAGTGATGCTTCCCTTCCT
  AAGGCTGACCAAGACCTGTTGATCCTTTTAGATTAAAAATAAAATGTCGCATGTAAAGGC
  TGAAGTCGCGTTTTATCAGAATGCCTTGCCTTCTTAGGTTCTTTTCCATTATGTCAAAGG
  TCCAGGCTCCAGTAGGAGAGAAAGAACTCCTCATAGGAATACTGAAGAAGTGGGAAGGAA
  CCAAGCTGACACAGGCCTCACTGCAATTTGATATGCCTGCTGATCAGAGTCTCTTGGGCA
  TTTTATATTTTGCATTCTGATGTACCTAGGAGTTTTGTTAAACAGATGATGTATGTGAGT
  ATTTATCCCATTTTATGCAATTAACCAAATCAACCAAAAAAAGTGACCATGAAGTCCTGT
  ATTTGTCTTTTTACTACATGTAGGAACTCTCATGTGAATGAGTACTGTAGTAATCCATTC
  TATGGGAGCCTTATTTCAGAAATATTTCAAACTGGTGCAAATGGAAAAGACTTTCTCTTT
  TCCTTTAAAGCTAAAGACAAGAATATCATGCTATACAGGTGCAACTCAATCCCCGTTAAT
  AAAAACCAATGTAGGTATAGGCATTCTACCCTTTGAAATAGCTGTGTCCCAACCTGTTGC
  CATTGATTTTTTGGAAATGGCTTTAGAAATATCCAAGTTGTCCTTGAATTGTCTAACCAT
  GGACATAAACAGTTGTCTCCCTTCTACTGTGTAGAATACTTTGACTTAATTTTCTTCCAG
  ATACAGGGGGATACCTGCCTGTTTTTCAAAGTGTTTATTTACTGCTGTTACTATTTGATT
  AGAATGTATTAAATAAAAAAAACCTGATTTCTGCAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003877.3 unedited
  TGCATTGTATACGACTCCTATAGGGCGGCTCGGGTAATTCGGCCATCTACGGCCGGGGCA
  GTGGGTGACCGCGGCTGCGAGGGACTTTGTCATCGGTCCTCCAGGATCTGGGGAGAAAGA
  GCCCCATCCCTTCTCTCTCTGCCACCATTTCGGACACCCCGCAGGGACTCGTTTTGGGAT
  TCGCACTGACTTCAAGGAAGGACGCGAACCCTTCTCTGACCCCAGCTCGGGCGGCCACCT
  GTCTTTGCCGCGGTGACCCTTCTCTCATGACCCTGCGGTGCCTTGAGCCCTCCGGGAATG
  GCGGGGAAGGGACGCGGAGCCAGTGGGGTTTTCGCGGGGTCGGCGGAGGAGCCATCCCCG
  CAGGCGGCGCGTCTGGCGAAGGCCCTGCGGGAGCTCGGTCAGACAGGATGGTACTGGGGA
  AGTATGACTGTTAATGAAGCCAAAGAGAAATTAAAAGAGGCACCAGAAGGAACTTTCTTG
  ATTAGAGATAGCTCGCATTCAGACTACCTACTAACAATATCTGTTAAAACATCAGCTGGA
  CCAACTAATCTTCGAATCGAATACCAAGACGGAAAATTCAGATTGGACTCTATCATATGT
  GTCAAATCCAAGCTTAAACAATTTGACAGTGTGGTTCATCTGATCGACTACTATGTTCAG
  ATGTGCAAGGATAAGCGGACAGGTCCAGAAGCCCCCCGGAACGGCACTGTTCACCTTTAT
  CTGACCAAACCGCTCTACACGTCAGCACCATCTCTGCAGCATCTCTGTAGGCTCACCATT
  AACAAATGTACCGGTGCCATCTGGGGACTGCCTTTACCACAGACTAAGATACTGGAGAAT
  ATAAATCCAGTATAATGTTTCTCTTTTTTTAACATGTCTAATAAGTATCTCCGATGCAGC
  TTTGTAAGAGAAACAAACCTGAAGGCTCTGGAAACCTATTGGAAGTGCTTCTCT
• Restriction Sites: Please inquire
• ACCN: NM_003877
• ORF Size: 597 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_003877.3, NP_003868.1
• RefSeq Size: 2210
• RefSeq ORF: 597
• Locus ID: 8835
• Domains: SH2, SOCS
• Protein Families: Druggable Genome
• Protein Pathways: Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus
• Gene Summary: This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
  Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 5. Variants 1-6 encode the same protein.