TXNIP (NM_006472) Human Untagged Clone

CAT#: SC108573

TXNIP (untagged)-Human thioredoxin interacting protein (TXNIP)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TXNIP
• Synonyms: ARRDC6; EST01027; HHCPA78; THIF; VDUP1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_006472 edited
  GTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCGTTTAGTGAACCGTCAGAATT
  TTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCCTCGTGCCGAATTC
  GGCACGAGGCTTTTTCTCCAAAGGAGTGCTTGTGGAGATCGGATCTTTTCTCCAGCAATT
  GGGGGAAAGAAGGCTTTTTCTCTGAATTCGCTTAGTGTAACCAGCGGCGTATATTTTTTA
  GGCGCCTTTTCGAAAACCTAGTAGTTAATATTCATTTGTTTAAATCTTATTTTATTTTTA
  AGCTCAAACTGCTTAAGAATACCTTAATTCCTTAAAGTGAAATAATTTTTTGCAAAGGGG
  TTTCCTCGATTTGGAGCTTTTTTTTTCTTCCACCGTCATTTCTAACTCTTAAAACCAACT
  CAGTTCCATCATGGTGATGTTCAAGAAGATCAAGTCTTTTGAGGTGGTCTTTAACGACCC
  TGAAAAGGTGTACGGCAGTGGCGAGAAGGTGGCTGGCCGGGTGATAGTGGAGGTGTGTGA
  AGTTACTCGTGTCAAAGCCGTTAGGATCCTGGCTTGCGGAGTGGCTAAAGTGCTTTGGAT
  GCAGGGATCCCAGCAGTGCAAACAGACTTCGGAGTACCTGCGCTATGAAGACACGCTTCT
  TCTGGAAGACCAGCCAACAGGTGAGAATGAGATGGTGATCATGAGACCTGGAAACAAATA
  TGAGTACAAGTTCGGCTTTGAGCTTCCTCAGGGGCCTCTGGGAACATCCTTCAAAGGAAA
  ATATGGGTGTGTAGACTACTGGGTGAAGGCTTTTCTTGACCGCCCGAGCCAGCCAACTCA
  AGAGACAAAGAAAAACTTTGAAGTAGTGGATCTGGTGGATGTCAATACCCCTGATTTAAT
  GGCACCTGTGTCTGCTAAAAAAGAAAAGAAAGTTTCCTGCATGTTCATTCCTGATGGGCG
  GGTGTCTGTCTCTGCTCGAATTGACAGAAAAGGATTCTGTGAAGGTGATGAGATTTCCAT
  CCATGCTGACTTTGAGAATACATGTTCCCGAATTGTGGTCCCCAAAGCTGCCATTGTGGC
  CCGCCACACTTACCTTGCCAATGGCCAGACCAAGGTGCTGACTCAGAAGTTGTCATCAGT
  CAGAGGCAATCATATTATCTCAGGGACATGCGCATCATGGCGTGGCAAGAGCCTTCGGGT
  TCAGAAGATCAGGCCTTCTATCCTGGGCTGCAACATCCTTCGAGTTGAATATTCCTTACT
  GATCTATGTTAGCGTTCCTGGATCCAAGAAGGTCATCCTTGACCTGCCCCTGGTAATTGG
  CAGCAGATCAGGTCTAAGCAGCAGAACATCCAGCATGGCCAGCCGAACCAGCTCTGAGAT
  GAGTTGGGTAGATCTGAACATCCCTGATACCCCAGAAGCTCCTCCCTGCTATATGGATGT
  CATTCCTGAAGATCACCGATTGGAGAGCCCAACCACTCCTCTGCTAGATGACATGGATGG
  CTCTCAAGACAGCCCTATCTTTATGTATGCCCCTGAGTTCAAGTTCATGCCACCACCGAC
  TTATACTGAGGTGGATCCCTGCATCCTCAACAACAATGTGCAGTGAGCATGTGGAAGAAA
  AGAAGCAGCTTTACCTACTTGTTTCTTTTTGTCTCTCTTCCTGGACACTCACTTTTTCAG
  AGACTCAACAGTCTCTGCAATGGAGTGTGGGTCCACCTTAGCCTCTGACTTCCTAATGTA
  GGAGGTGGTCAGCAGGCAATCTCCTGGGCCTTAAAGGATGCGGACTCATCCTCAGCCAGC
  GCCCATGTTGTGATACAGGGGTGTTTGTTGGATGGGTTTAAAAATAACTAGAAAAACTCA
  GGCCCATCCATTTTCTCAGATCTCCTTGAAAATTGAGGCCTTTTCGATAGTTTCGGGTCA
  GGTAAAAATGGCCTCCTGGCGTAAGCTTTTCAAGGTTTTTTGGAGGCTTTTTGTAAATTG
  TGATAGGAACTTTGGACCTTGAACTTACGTATCATGTGGAGAAGAGCCAATTTAACAAAC
  TAGGAAGATGAAAAGGGAAATTGTGGCCAAAACTTTGGGAAAAGGAGGTTCTTAAAATCA
  GTGTTTCCCCTTTGTGCACTTGTAGAAAAAAAAGAAAAACCTTCTAGAGCTGATTTGATG
  GACAATGGAGAGAGCTTTCCCTGTGATTATAAAAAAGGAAGCTAGCTGCTCTACGGTCAT
  CTTTGCTTAGAGTATACTTTAACCTGGCTTTTAAAGCAGTAGTAACTGCCCCACCAAAGG
  TCTTAAAAGCCATTTTTGGAGCCTATTGCACTGTGTTCTCCTACTGCAAATATTTTCATA
  TGGGAGGATGGTTTTCTCTTCATGT
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_006472 unedited
  TACGATATTTGTATACGACTTCACTATAGGGCGGCCGCGAATTCGCACGAGGCCTCGTGC
  CGAATTCGGCACGAGGCTTTTTCTCCAAGGAGTGCTTGTGGAGATCGGATCTTTTCTCCA
  GCAATTGGGGGAAAGAAGGCTTTTTCTCTGAATTCGCTTAGTGTAACCAGCGGCGTATAT
  TTTTTAGGCGCCTTTTCGAAAACCTAGTAGTTAATATTCATTTGTTTAAATCTTATTTTA
  TTTTTAAGCTCAAACTGCTTAAGAATACCTTAATTCCTTAAAGTGAAATAATTTTTTGCA
  AAGGGGTTTCCTCGATTTGGAGCTTTTTTTTTCTTCCACCGTCATTTCTAACTCTTAAAA
  CCAACTCAGTTCCATCATGGTGATGTTCAAGAAGATCAAGTCTTTTGAGGTGGTCTTTAA
  CGACCCTGAAAAGGTGTACGGCAGTGGCGAGAAGGTGGCTGGCCGGGTGATAGTGGAGGT
  GTGTGAAGTTACTCGTGTCAAAGCCGTTAGGATCCTGGCTTGCGGAGTGGCTAAAGTGCT
  TTGGATGCAGGGATCCCAGCAGTGCAAACAGACTTCGGAGTACCTGCGCTATGAAGACAC
  GCTTCTTCTGGAAGACCAGCCAACAGGTGAGAATGAGATGGTGATCATGAGACCTGGAAA
  CAATATGAGTACAAGTTCGGCTTTGAGCTTCCTCAGGGGCCTCTGGGAACATCCTTCAAA
  GAAAATATGGGTGTGTAGACTACTGGGTGAAGGCTTTTCTTGACCGCCCGAGCCAGCCAA
  CTCAAGAGACAAAGAAAACTTTGAAATACTGGATCTGGTGGGAGGCAATACCCCTGATTA
  ATGCCACCTGGGTCTGCTAAAAAGAAAAGAAGTTCCTGCATGTTCCTCCTGAAGGGCGGG
  TGGCTGTCTCTGCTTCAATTGCACCAAAGGAATCTGT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_006472 unedited
  NGGTTTTTGCTGTGNNAAGACGGCCCGCTTTTCTAAGATCGAGTTTTTTTTTTTTTTTTT
  TCCATTAAAAAAACTTTATTTTCATTTTTTACAAAAAAACCCCCATCTGGGGTAAAAAAT
  ATCTGGTTAAGTACAAAATATAGTCTTTACCATACAAAAAGATACATAATACAAAAACAT
  GAAACCAACCATCTTCAGCCCACACTTTCTGGCTGTAATAACTCTCAGAAAAGGGTGGAG
  CTCAGTGCTCTGACACAGGACAGTGAACAAAGTGCTATGGCTGAGAGTGACTGACCAAGT
  GCTGGCAGCTGCAGTGAGGGGCCAATATCCCTATCTCCTAACACAGGGCAGGAAGGGGGT
  TCAAAGGGCTTTTATGAAGACCTGCCCTCTAGTTTCTCATGGCAGTATTTGGAGGTTCTG
  ATCACAGGGTTGGGCATTTTGATCAAGAGTCCCTCCTTGGGTTCGAAGCCACAGCGGGCA
  AGGCTGACAGCAGCAACCCTCTCACATGCTTCAAGTGCTACAACCATATACCTCCGCCCA
  TCGGGGTAATCTCAAAAGCAGTACAAATCTCTCCCGTCTCTCTGCATTCACCCCTATTCC
  ACATCAGCCACCCTATTCTCCCGTCTTACATTGTATGATGGTCCCACGGCGGCCCAACAT
  AACCCCGTGACCAGGCACTTCACAGTGGCTTAACACACATAACCCTTTATACCCTCCCCC
  CTCAGGACCTCCACCGCACATAGACCACCCTTCCTACCTTAACCGATACAACACTCGCAG
  CCAGGCAATTCCCAGCGTGAAAAGGGCTCCCACCACCGGCCCTCTACAGCACCTCCCGTG
  GGGCGGTGATTACTACCTGCCCTTTCTCACCCATCTCCTAACTTTTCCCTTTATCCCCCT
  TTACCCGTAATGGAAAAAATTACCTTCCTCTCCACCCAGCCCAAACCCCTCTCTCTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_006472
• ORF Size: 1176 bp
• Insert Size: 2260
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_006472.1, NP_006463.2
• RefSeq Size: 2704
• RefSeq ORF: 1176
• Locus ID: 10628
• Domains: arrestin
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.