PARL (NM_018622) Human Untagged Clone

CAT#: SC108782

PARL (untagged)-Human presenilin associated, rhomboid-like (PARL), nuclear gene encoding mitochondrial protein, transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PARL
• Synonyms: PRO2207; PSARL; PSARL1; PSENIP2; RHBDS1
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC108782 sequence for NM_018622 edited (data generated by NextGen Sequencing)
  ATGGCGTGGCGAGGCTGGGCGCAGAGAGGCTGGGGCTGCGGCCAGGCGTGGGGTGCGTCG
  GTGGGCGGCCGCAGCTGCGAGGAGCTCACTGCGGTCCTAACCCCGCCGCAGCTCCTCGGA
  CGCAGGTTTAACTTCTTTATTCAACAAAAATGCGGATTCAGAAAAGCACCCAGGAAGGTT
  GAACCTCGAAGATCAGACCCAGGGACAAGTGGTGAAGCATACAAGAGAAGTGCTTTGATT
  CCTCCTGTGGAAGAAACAGTCTTTTATCCTTCTCCCTATCCTATAAGGAGTCTCATAAAA
  CCTTTATTTTTTACTGTTGGGTTTACAGGCTGTGCATTTGGATCAGCTGCTATTTGGCAA
  TATGAATCACTGAAATCCAGGGTCCAGAGTTATTTTGATGGTATAAAAGCTGATTGGTTG
  GATAGCATAAGACCACAAAAAGAAGGAGACTTCAGAAAGGAGATTAACAAGTGGTGGAAT
  AACCTAAGTGATGGCCAGCGGACTGTGACAGGTATTATAGCTGCAAATGTCCTTGTATTC
  TGTTTATGGAGAGTACCTTCTCTGCAGCGGACAATGATCAGATATTTCACATCGAATCCA
  GCCTCAAAGGTCCTTTGTTCTCCAATGTTGCTGTCAACATTCAGTCATTTCTCCTTATTT
  CACATGGCAGCAAATATGTATGTTTTGTGGAGCTTCTCTTCCAGCATAGTGAACATTCTG
  GGTCAAGAGCAGTTCATGGCAGTGTACCTATCTGCAGGTGTTATTTCCAATTTTGTCAGT
  TACGTGGGTAAAGTTGCCACAGGAAGATATGGACCATCACTTGGTGCATCTGGTGCCATC
  ATGACAGTCCTCGCAGCTGTCTGCACTAAGATCCCAGAAGGGAGGCTTGCCATTATTTTC
  CTTCCGATGTTCACGTTCACAGCAGGGAATGCCCTGAAAGCCATTATCGCCATGGATACA
  GCAGGAATGATCCTGGGATGGAAATTTTTTGATCATGCGGCACATCTTGGGGGAGCTCTT
  TTTGGAATATGGTATGTTACTTACGGTCATGAACTGATTTGGAAGAACAGGGAGCCGCTA
  GTGAAAATCTGGCATGAAATAAGGACTAATGGCCCCAAAAAAGGAGGTGGCTCTAAGTAA
  
  Clone variation with respect to NM_018622.5
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_018622 unedited
  TCAAATTTGTATACGACTCCTATAGGGCGGCCGCGAATTCGCACCAGGGGGCAGAGGTTG
  GGAAGATGGCGTGGCGAGGCTGGGCGCAGAGAGGCTGGGGCTGCGGCCAGGCGTGGGGTG
  CGTCGGTGGGCGGCCGCAGCTGCGAGGAGCTCACTGCGGTCCTAACCCCGCCGCAGCTCC
  TCGGACGCAGGTTTAACTTCTTTATTCAACAAAAATGCGGATTCAGAAAAGCACCCAGGA
  AGGTTGAACCTCGAAGATCAGACCCAGGGACAAGTGGTGAAGCATACAAGAGAAGTGCTT
  TGATTCCTCCTGTGGAAGAAACAGTCTTTTATCCTTCTCCCTATCCTATAAGGAGTCTCA
  TAAAACCTTTATTTTTTACTGTTGGGTTTACAGGCTGTGCATTTGGATCAGCTGCTATTT
  GGCAATATGAATCACTGAAATCCAGGGTCCAGAGTTATTTTGATGGTATAAAAGCTGATT
  GGTTGGATAGCATAAGACCACAAAAAGAAGGAGACTTCAGAAAGGAGATTAACAAGTGGT
  GGAATAACCTAAGTGATGGCCAGCGGACTGTGACAGGTATTATAGCTGCAAATGTCCTTG
  TATTCTGTTTATGGAGAGTACCTTCTCTGCAGCGGACAATGATCAGATATTTCACATCGA
  ATCCAGCCTCAAAGGTCCTTTGTTCTCCAATGTTGCTGTCAACATTCAGTCATTTCTCCT
  TATTTCACATGGCAGCAAATATGTATGTTTTGTGGAGCTTCTCTTCAGCATAGTGAACAT
  TCTGGGTCAAGAGCAGTTCATGGCAGTGTACCTATCTNGCAGTGTTATTTCCAATTTTGT
  CAGTTACGTGGGTAAAAGTGCCACAGGAAGTATGGACCATCACTTGGTGCATCTGGTGCC
  ATCATGACAGTCCTCGCAGCTGTCTGCACTTAGATCCAGAAGGGAGGGCTGCCATTATNT
  NCCTTTCGATGGTCACGTTCCAGCCAGGGAATGCCCTGNAAGCCATTATCGN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_018622
• ORF Size: 1140 bp
• Insert Size: 1000
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_018622.4, NP_061092.3
• RefSeq Size: 1384
• RefSeq ORF: 1140
• Locus ID: 55486
• Domains: Rhomboid
• Protein Families: Protease, Transmembrane
• Gene Summary: This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease. [provided by RefSeq, May 2016]
  Transcript Variant: This variant (1) encodes the longest isoform (1), which is localized to the mitochondria.