ITM2B (NM_021999) Human Untagged Clone

CAT#: SC108808

ITM2B (untagged)-Human integral membrane protein 2B (ITM2B)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ITM2B
• Synonyms: ABRI; BRI; BRI2; BRICD2B; E3-16; E25B; FBD; imBRI2; RDGCA
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC108808 sequence for NM_021999 edited (data generated by NextGen Sequencing)
  ATGGTGAAGGTGACGTTCAACTCCGCTCTGGCCCAGAAGGAGGCCAAGAAGGACGAGCCC
  AAGAGCGGCGAGGAGGCGCTCATCATCCCCCCCGACGCCGTCGCGGTGGACTGCAAGGAC
  CCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTTTGGA
  CTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTTTGCA
  CTTCAACCAGATGACGTGTACTACTGTGGAATAAAGTACATCAAAGATGATGTCATCTTA
  AATGAGCCCTCTGCAGATGCCCCAGCTGCTCTCTACCAGACAATTGAAGAAAATATTAAA
  ATCTTTGAAGAAGAAGAAGTTGAATTTATCAGTGTGCCTGTCCCAGAGTTTGCAGATAGT
  GATCCTGCCAACATTGTTCATGACTTTAACAAGAAACTTACAGCCTATTTAGATCTTAAC
  CTGGATAAGTGCTATGTGATCCCTCTGAACACTTCCATTGTTATGCCACCCAGAAACCTA
  CTGGAGTTACTTATTAACATCAAGGCTGGAACCTATTTGCCTCAGTCCTATCTGATTCAT
  GAGCACATGGTTATTACTGATCGCATTGAAAACATTGATCACCTGGGTTTCTTTATTTAT
  CGACTGTGTCATGACAAGGAAACTTACAAACTGCAACGCAGAGAAACTATTAAAGGTATT
  CAGAAACGTGAAGCCAGCAATTGTTTCGCAATTCGGCATTTTGAAAACAAATTTGCCGTG
  GAAACTTTAATTTGTTCTTGA
  
  Clone variation with respect to NM_021999.4
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_021999 unedited
  TTGTATACGACTCACTATAGGGCGGCCGCGATTCGGCACGAGGCCGCCGCGGAGCTTCCC
  GAACCTCTTCAGCCGCCCGGAGCCGCTCCCGGAGCCCGGCCGTAGAGGCTGCAATCGCAG
  CCGGGAGCCCGCAGCCCGCGCCCCGAGCCCGCCGCCGCCCTTCGAGGGCGCCCCAGGCCG
  CGCCATGGTGAAGGTGACGTTCAACTCCGCTCTGGCCCAGAAGGAGGCCAAGAAGGACGA
  GCCCAAGAGCGGCGAGGAGGCGCTCATCATCCCCCCCGACGCCGTCGCGGTGGACTGCAA
  GGACCCAGATGATGTGGTACCAGTTGGCCAAAGAAGAGCCTGGTGTTGGTGCATGTGCTT
  TGGACTAGCATTTATGCTTGCAGGTGTTATTCTAGGAGGAGCATACTTGTACAAATATTT
  TGCACTTCAACCAGATGACGTGTACTACTGTGGAATAAAGTACATCAAAGATGATGTCAT
  CTTAAATGAGCCCTCTGCAGATGCCCCAGCTGCTCTCTACCAGACAATTGAAGAAAATAT
  TAAAATCTTTGAAGAAGAAGAAGTTGAATTTTTCAGTGTGCCTGTCCCAGAGTTTGCAGA
  TAGTGATCCTGCCAACATTGTTCATGACTTTAACAAGAAACTTACAGCCTATTTAGATCT
  TAACCTGNATAAGTGCTNATGTGATCCCTCTGAACACTTNCATTGTTATGCCACCCAGAA
  ACCTACTGGGAGNTACTTATTAACATCAAGGGCTGGAAACCTATTTGCCTCAGTCCTATC
  TGATTCATGAGCACATGGTTATTACTGGATCGCATTGAAACATTGATCACNTGGGGTTTC
  TTTTATTTATCGACTGGTGTCATGACAAGGAAACTTACAAACTGGCACGCANNAGAACTT
  T
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_021999 unedited
  NNTTTTAGCTATGGACCCGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTCT
  AGTTAAACAACTTTGTGATATTTATATTCCATTGCACAGATATGGGTTATACAAATTAGT
  AACACAAGTTATTTCTTAAATTCCAAACATTTTCTAAAATATTATTACAGCAGATGCCTA
  GGATATTAAAACATAAAGGTGGAAATCATTCTCTAAATAGTTAAATATATTTGACACTGA
  AAATACTGCACATTTTAATTAGAGGAAAATTAAAATGTGTGCTCAAATGCACTAACAAAC
  TAGGTAGCAGGGCAACTAACAACTACAAATAAGTCACTGTGGTCCATTTTTACGTATGCA
  TATATATGATTATTCTCTAGATAATCCGTCTTCTTGAAAATGCTAATAAAACATAAAAAT
  CCAGATAAATGATTTAAAGAAATTGTAATTCTTCCTACTACCTAAGGTGACATGTACTAT
  TATCTATGACTTCATACAGTTACTAATTCAAATATAAAAGACACCACACTTCGAAAGAAA
  AAAATTTTAAGGTAATGGTTCTAATTGAATTAATGAGATGAAAAGATAGTAAAGCCCTGT
  TTGCTACTTACATGAAAGAAGACTTTAAAAAAATATCACTGCACANAATGTAAAGGGTGG
  GGTTATGCTGAGATACTAATTTCCCTCAATAATGTTTTTCTTGACTGTTCAAGAACAAAT
  TAAAGTTCCACGGCATATTTGTTTTCAAATGCCCGAATGCGAAACAATTGTTGGCTTTAC
  GTTTCTGAATACCCTTAATAGTTCTTTGCGGTGCAATTTGTAAGTTCCCCTGCCTGACCA
  GCNCGATAATAAAGAACCCAGGTGAACAAGGTTTCATGCCAACATAAAACCATGGGCCCA
  A
  
• Restriction Sites: NotI-NotI
• ACCN: NM_021999
• ORF Size: 801 bp
• Insert Size: 1500
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_021999.2, NP_068839.1
• RefSeq Size: 1896
• RefSeq ORF: 801
• Locus ID: 9445
• Domains: BRICHOS
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]