Beta Arrestin 2 (ARRB2) (NM_004313) Human Untagged Clone

CAT#: SC108950

ARRB2 (untagged)-Human arrestin, beta 2 (ARRB2), transcript variant 1


  "NM_004313" in other vectors (6)

Reconstitution Protocol

USD 310.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol ARRB2
Synonyms ARB2; ARR2; BARR2
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_004313 edited
GAATTCGGCACGAGGTGGCAGCGGGCGAGGAGGCTGCGAGCGAGCCGCGAACCGAGCGGG
CGGCGGGCGCGCGCACCATGGGGGAGAAACCCGGGACCAGGGTCTTCAAGAAGTCGAGCC
CTAACTGCAAGCTCACCGTGTACTTGGGCAAGCGGGACTTCGTAGATCACCTGGACAAAG
TGGACCCTGTAGATGGCGTGGTGCTTGTGGACCCTGACTACCTGAAGGACCGCAAAGTGT
TTGTGACCCTCACCTGCGCCTTCCGCTATGGCCGTGAAGACCTGGATGTGCTGGGCTTGT
CCTTCCGCAAAGACCTGTTCATCGCCACCTACCAGGCCTTCCCCCCGGTGCCCAACCCAC
CCCGGCCCCCCACCCGCCTGCAGGACCGGCTGCTGAGGAAGCTGGGCCAGCATGCCCACC
CCTTCTTCTTCACCATACCCCAGAATCTTCCATGCTCCGTCACACTGCAGCCAGGCCCAG
AGGATACAGGAAAGGCCTGCGGCGTAGACTTTGAGATTCGAGCCTTCTGTGCTAAATCAC
TAGAAGAGAAAAGCCACAAAAGGAACTCTGTGCGGCTGGTGATCCGAAAGGTGCAGTTCG
CCCCGGAGAAACCCGGCCCCCAGCCTTCAGCCGAAACCACACGCCACTTCCTCATGTCTG
ACCGGTCCCTGCACCTCGAGGCTTCCCTGGACAAGGAGCTGTACTACCATGGGGAGCCCC
TCAATGTAAATGTCCACGTCACCAACAACTCCACCAAGACCGTCAAGAAGATCAAAGTCT
CTGTGAGACAGTACGCCGACATCTGCCTCTTCAGCACCGCCCAGTACAAGTGTCCTGTGG
CTCAACTCGAACAAGATGACCAGGTATCTCCCAGCTCCACATTCTGTAAGGTGTACACCA
TAACCCCACTGCTCAGTGACAACCGGGAGAAGCGGGGTCTCGCCCTGGATGGGAAACTCA
AGCACGAGGACACCAACCTGGCTTCCAGCACCATCGTGAAGGAGGGTGCCAACAAGGAGG
TGCTGGGAATCCTGGTGTCCTACAGGGTCAAGGTGAAGCTGGTGGTGTCTCGAGGCGGGG
ATGTCTCTGTGGAGCTGCCTTTTGTTCTTATGCACCCCAAGCCCCACGACCACATCCCCC
TCCCCAGACCCCAGTCAGCCGCTCCGGAGACAGATGTCCCTGTGGACACCAACCTCATTG
AATTTGATACCAACTATGCCACAGATGATGACATTGTGTTTGAGGACTTTGCCCGGCTTC
GGCTGAAGGGGATGAAGGATGACGACTATGATGATCAACTCTGCTAGGAAGCGGGGTGGG
AAGAAGGGAGGGGATGGGGTTGGGAGAGGTGAGGGCAGGATTAAGATCCCCACTGTCAAT
GGGGGATTGTCCCAGCCCCTCTTCCCTTCCCCTCACCTGGAAGCTTCTTCAACCAATCCC
TTCACACTCTCTCCCCCATCCCCCCAAGATACACACTGGACCCTCTCTTGCTGAATGTGG
GCATTAATTTTTTGACTGCAGCTCTGCTTCTCCAGCCCCGCCGTGGGTGGCAAGCTGTGT
TCATACCTAAATTTTCTGGAAGGGGACAGTGAAAAGAGGAGTGACAGGAGGGAAAGGGGG
AGACAAAACTCCTACTCTCAACCTCACACCAACACCTCCCATTATCACTCTCTCTGCCCC
CATTCCTTCAAGAGGAGACCCTTTGGGGACAAGGCCGTTTCTTTGTTTCTGAGCATAAAG
AAGAAAATAAATCTTTTACTAAGAAAAAAAAAAAAAAAAAAACTCGAC
>OriGene 5' read for NM_004313 unedited
TGTCAGAAATTTTGTATACGAACTCACTATAGGGCGGCCGCGATTCGGCACGAGGTGGCA
GCGGGCGAGGAGGCTGCGAGCGAGCCGCGAACCGAGCGGGCGGCGGGCGCGCGCACCATG
GGGGAGAAACCCGGGACCAGGGTCTTCAAGAAGTCGAGCCCTAACTGCAAGCTCACCGTG
TACTTGGGCAAGCGGGACTTCGTAGATCACCTGGACAAAGTGGACCCTGTAGATGGCGTG
GTGCTTGTGGACCCTGACTACCTGAAGGACCGCAAAGTGTTTGTGACCCTCACCTGCGCC
TTCCGCTATGGCCGTGAAGACCTGGATGTGCTGGGCTTGTCCTTCCGCAAAGACCTGTTC
ATCGCCACCTAACCAGGCCTTCCCCCCCGGTGCCCAACCCACCCCGGCCCCCCACCCGCC
TGCAGGACCGGCTGCTGAGGAAGCTGGGCCAGCATGCCCACCCCTTCTTCTTCACCATAC
CCCAGAATCTTCCATGCTCCGTCACACTGCAGCCAGGCCCAGAGGATACAGGAAAGGCCT
GCGGCGTAGACTTTGAGATTCGAGCCTTCTGTGCTAAATCACTAGAAGAGAAAAGCCACA
AAAGGAACTCTGTGCGGCTGGTGATCCGAAAGGTGCAGTTCGCCCCGGAGAAACCCGGCC
CCCAGCCTTCAGCCGAAACCACACGCCACTTCCTCATGTCTGACCGGTCCCTGCACCTCG
AGGCTTCCCTGGACAGGGAGCTGTACTACCATGGNGAGCCCCTCATGTANATGTCCACGT
CACCAACAACTCCACCAAGACCGTNCAGAAGATCANAGTCTCTGTGAGACAGTACGCCGA
CATCTGCCTCTTCAGCACCGCCCAGTACAAGTGTCCTGTGGCTCAACTCGAACAGAATGA
CCAGTATCTCCCCAGCTCCATA
>OriGene 3' read for NM_004313 unedited
GCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTCTTAGTAAAAGATTTATTTTTC
TTCTTTATGCTCAGAAACAAAGAAACGGCCTTGTCCCCAAAGGGTCTCCTCTTGAAGGAA
TGGGGGCAGAGAGAGTGATAATGGGAGGTGTTGGTGTGAGGTTGAAAGTAGGAGTTTTGT
CTCCCCCTTTCCCTCCTGTCACTCCTCTTTTCACTGTCCCCTTCCAGAAAATTTAGGTAT
GAACACAGCTTGCCACCCACGGCGGGGCTGGAGAAGCAGAGCTGCAGTCAAAAAATTAAT
GCCCACATTCAGCAAGAGAGGGTCCAGTGTGTATCTTGGGGGGATGGGGGAGAGAGTGTG
AAGGGATCTGGTTTGAAGAAGCTTCCAGGTGAGGGGAAGGGAAGAGGGGCTGGGACAATC
CCCCATTGACAGTGGGGATCTTAATCCTGCCCTCACCTCTCCCAACCCCATCCCCTCCCT
TCTTCCCACCCCGCTTCCTAGCAGAGTTGATCATCATAGTCGTCATCCTTCATCCCCTTC
AGCCGAAGCCGGGCAAAGTCCTCAAACACAATGTCATCATCTGTGGCATAGTTGGTATCA
AATTCAATGAGGTTTGGTGTCCACAGGGACATCTGTCTCCGGAGCGGCTGACTGGGGTCT
GAGGATGGGGNATGCTGGTCNTGGGGGCTGGGGGTGCATAANAACAAAGGCATCTGCCAG
AGACATCCCCGCCTCGAGACACACAAGTTTAACCTAGACCCTGTAAGACACCAGGATTCC
CAGCACTTCCTTGNTGGCACCCTNCTCACGATGGTGCTGGAAGCCAGGTTGGTGTCCTCG
AGCTTGAGTTTGCATTCAGGGCGATACCCCGCTCTCCCGGTTGCACTGGCCATGGGGGTT
GGGGGTCCCCTACAAATTGGGAGCGGGAATCCCGGCATCTTGTCAATTGACCCAGGCCTT
GTCCTGGCGGGCGAAGA
Restriction Sites NotI-NotI     
ACCN NM_004313
Insert Size 1880 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_004313.3, NP_004304.1
RefSeq Size 1936 bp
RefSeq ORF 1230 bp
Locus ID 409
Cytogenetics 17p13.2
Domains arrestin
Protein Families Druggable Genome
Protein Pathways Chemokine signaling pathway, Endocytosis, MAPK signaling pathway, Olfactory transduction
Gene Summary 'Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]'
Transcript Variant: This variant (1) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 3. The resulting isoform (1) lacks an alternate internal segment compared to isoform 3.

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