BAD (NM_032989) Human Untagged Clone

CAT#: SC108970

BAD (untagged)-Human BCL2-associated agonist of cell death (BAD), transcript variant 2


  "NM_032989" in other vectors (6)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol BAD
Synonyms BBC2; BCL2L8
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_032989 edited
GAATTCGGCACGAGGGGCAGGCCCGGGTCAGGGGCCTCGAGATCGGGCTTGGGCCCAGAG
CATGTTCCAGATCCCAGAGTTTGAGCCGAGTGAGCAGGAAGACTCCAGCTCTGCAGAGAG
GGGCCTGGGCCCCAGCCCCGCAGGGGACGGGCCCTCAGGCTCCGGCAAGCATCATCGCCA
GGCCCCAGGCCTCCTGTGGGACGCCAGTCACCAGCAGGAGCAGCCAACCAGCAGCAGCCA
TCATGGAGGCGCTGGGGCTGTGGAGATCCGGAGTCGCCACAGCTCCTACCCCGCGGGGAC
GGAGGACGACGAAGGGATGGGGGAGGAGCCCAGCCCCTTTCGGGGCCGCTCGCGCTCGGC
GCCCCCCAACCTCTGGGCAGCACAGCGCTATGGCCGCGAGCTCCGGAGGATGAGTGACGA
GTTTGTGGACTCCTTTAAGAAGGGACTTCCTCGCCCGAAGAGCGCGGGCACAGCAACGCA
GATGCGGCAAAGCTCCAGCTGGACGCGAGTCTTCCAGTCCTGGTGGGATCGGAACTTGGG
CAGGGGAAGCTCCGCCCCCTCCCAGTGACCTTCGCTCCACATCCCGAAACTCCACCCGTT
CCCACTGCCCTGGGCAGCCATCTTGAATATGGGCGGAAGTACTTCCCTCAGGCCTATGCA
AAAAGAGGATCCGTGCTGTCTCCTTTGGAGGGAGGGCTGACCCAGATTCCCTTCCGGTGC
GTGTGAAGCCACGGAAGGCTTGGTCCCATCGGAAGTTTTGGGTTTTCCGCCCACAGCCGC
CGGAAGTGGCTCCGTGGCCCCGCCCTCAGGCTCCGGGCTTTCCCCCAGGCGCCTGCGCTA
AGTCGCGAGCCAGGTTTAACCGTTGCGTCACCGGGACCCGAGCCCCCGCGATGCCCTGGG
GGCCGTGCTCACTACCAAATGTTAATAAAGCCCGCGTCTGTGCCGCCAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAACTCGAC
>OriGene 5' read for NM_032989 unedited
GGTCANAATATGTATACGACTCCTATAGGGCGGCCGCGAATTCGCACGAGGGGCAGGCCC
GGGTCAGGGGCCTCGAGATCGGGCTTGGGCCCAGAGCATGTTCCAGATCCCAGAGTTTGA
GCCGAGTGAGCAGGAAGACTCCAGCTCTGCAGAGAGGGGCCTGGGCCCCAGCCCCGCAGG
GGACGGGCCCTCAGGCTCCGGCAAGCATCATCGCCAGGCCCCAGGCCTCCTGTGGGACGC
CAGTCACCAGCAGGAGCAGCCAACCAGCAGCAGCCATCATGGAGGCGCTGGGGCTGTGGA
GATCCGGAGTCGCCACAGCTCCTACCCCGCGGGGACGGAGGACGACGAAGGGATGGGGGA
GGAGCCCAGCCCCTTTCGGGGCCGCTCGCGCTCGGCGCCCCCCAACCTCTGGGCAGCACA
GCGCTATGGCCGCGAGCTCCGGAGGATGAGTGACGAGTTTGTGGACTCCTTTAAGAAGGG
ACTTCCTCGCCCGAAGAGCGCGGGCACAGCAACGCAGATGCGGCAAAGCTCCAGCTGGAC
GCGAGTCTTCCAGTCCTGGTGGGATCGGAACTTGGGCAGGGGAAGCTCCGCCCCCTCCCA
GTGACCTTCGCTCCACATCCCGAAACTCCACCCGTTCCCACTGCCCTGGGCAGCCATCTT
GAATATGGGCGGAAGTACTTCCCTCAGGCCTATGCAAAAAGAGGATCCGTGCTGTCTCCT
TTGGAGGGAGGGCTGACCCAGATTCCCTTCCGGTGCGTGTGAAGCCACGGAAGGCTTGGT
CCCATCGGNAAGTTTGGGTTTTCCGCCCCAGCCGCCGAAGTGGCTNCGTGGCCCCCCCTC
AGCTCCGGCTTTCCCCCAGCGCTGCGCTAGTCGCGAGCCCAGTTACCGTTGCGTCACGGG
ACCCGACCCCGCGAGCCCTGGGGCGTGCTACTACCAATGTAA
>OriGene 3' read for NM_032989 unedited
TTACCGCGGCCGCATTCTANATCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTGGGGGGACAAACCCCGGCTTTATTAACATTTGGGAGTGAGCACCGGCCCCAA
GGCATTGCGGGGGCTCGGGTCCCGGGGACCCAACGGTTAAACCTGGCTTGCGACTTAACG
CAAGCGCCTGGGGGAAAACCCGGAACCTGAGGGCGGGGCCACGGAGCCACTTTCGGGGGG
TGGGGGCGGAAAACCCAAAACTTCCGATGGGACCAAACCTTCCGTGGGTTTACACCCCCC
GGAAGGGAATCTGGGTCAACCCTCCCTTCAAAGGAGACAGCACGGATCCTTTTTTTGCAT
AAGCCTGAGGGAAATACTTCCGCCCATATTCAAAAAGGCTGCCCAAGGCAATGGGAACGG
GTGGAGTTTCGGGATGTGGAACCAAAGTCACTGGGAGGGGGCGGAGCTTCCCCTGCCCAA
GTTCCGATCCCCCCAGGACTGGAAGACTCCCGTCCCGCTGGAGCCTTTCCGCATTTGCGT
TGTTGTGCCCCCGCTCTTTGGGCGAAGAAGTCCCTTTTTAAAGGAGGCCACAAAATCGTC
ACTTATTCCTCCGAACCTCCGGGCATATCGCCTTTGTTTCCCCAAGGTGGGGGGCCCCCA
CCCCCAACCGCCCCAAAGGGGCCTGGCTCTCCCCCCCTCCCTTCCGCTTCCCCTCTCCCC
CCCGGGCAGAACCTGCGCCAACTTCGATTCCCACTACCCAGGCCCCCATTACGGCCCCTC
CTGATTGTCCCCCTTCCTGCGCCCGCGCTTCACCGCGGCCCCGCGGCCCCCCATACCTCT
CTCCTAACCTTAAGGCTCCTCACCCTTGGGTTTTGACCTCCCCCTCTCTTCAACCTAACC
G
Restriction Sites NotI-NotI     
ACCN NM_032989
Insert Size 1090 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_032989.1, NP_116784.1
RefSeq Size 956 bp
RefSeq ORF 507 bp
Locus ID 572
Cytogenetics 11q13.1
Protein Families Druggable Genome
Protein Pathways Acute myeloid leukemia, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Focal adhesion, Insulin signaling pathway, Melanoma, Neurotrophin signaling pathway, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, VEGF signaling pathway
Gene Summary 'The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL (B-cell lymphoma-extra large) and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Dec 2019]'
Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

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